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Relation of Corrected QT Interval Dispersion with Severity of Coronary Artery Disease in patients with Non ST elevation Myocardial Infarction

Prof. Dr. Mansour Mohamed Mostafa¹, MD; Dr. Mohammad Moanes Mohammed, MD¹, Dr. Tarek Ahmed Dabash,

MD^2, and Mohamed Hussien Mousa Ahmed (MB.B.Ch)¹

¹Cardiology Department, Faculty of Medicine- Al-Azhar University, Cairo, Egypt

² Cardiology Department, Faculty of Medicine- Al-Azhar University, Damietta, Egypt

 Prof. Dr. Mansour Mohamed Mostafa, MD; Dr. Mohammad Moanes Mohammed, MD, Dr. Tarek Ahmed Dabash,

bassamxxx25@gmail.com

Abstract: Objective: Our aim is to study the relation between corrected QT dispersion and severity of coronary artery disease in patients with non ST elevation myocardial infarction. Patients and methods: This study was conducted on 60 patients attended at Cardiology department of Al-Azhar University Hospital at the period from January 2017 and august 2017. They were diagnosed as non ST elevation myocardial infarction. And the QT intervals is measured manually in all leads, and heart rate is corrected (QTc) using the Bazett’s formula it is square root method obtained by dividing the actual QT interval by the square root of the RR interval (QTc = QT/square root of R-R interval in seconds) then QTc dispersion was assessed from a 12-lead electrocardiogram (ECG) as the difference between the longest and shortest QTc intervals. Then they were subjected to coronary angiography within 72 hours after admission then Syntax Score was calculated by syntax calculator it is a new tool to grade the complexity of coronary artery disease and we do Correlation between QTc dispersion and syntax Score. Results: The study included 60 patients. The total number of males in the study was 40(66.67%), and the total number of females was 20 (33.33%). The age has ranged from 47 to 66 years and the mean age was (55.4±4.7) years. The mean of QTc dispersion was (59.65±5.81) m sec. There is significant positive correlation between syntax score and QTc dispersion, p=0.0001. Conclusion: QTc dispersion can be used as a simple, accurate and inexpensive tool correlated with the severity of coronary artery disease in patients with acute coronary syndrome. Recommendation: Further large scale studies should be carried out to confirm the relationship between QTc dispersion and severity of coronary artery disease. Measurement of QTc dispersion should be done routinely for all patients admitted with acute coronary syndrome.

[Mansour Mohamed Mostafa, Mohammad Moanes Mohammed, Tarek Ahmed Dabash, and Mohamed Hussien Mousa Ahmed. Relation of Corrected QT Interval Dispersion with Severity of Coronary Artery Disease in patients with Non ST elevation Myocardial Infarction. Researcher 2018;10(7):1-8]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 1. doi:10.7537/marsrsj100718.01.

Keywords: Relation; QT; Interval Dispersion; Coronary; Artery Disease; patient; Myocardial Infarction

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Role of Ultrasonography and MRI Arthrography in Diagnosis of Glenohumeral Instability

Ali Abdelhady Elsayed, Mohammad Abo Elnaga Mohammad and Abdulaziz Ali Mohammad

Radio-Daiagnosis Department, Sayed Galal University Hospital, Faculty of Medicine, Alazhar University, Cairo, Egypt
abdulaziz.oraby@gmail.com

Abstract: Introduction: Glenohumeral instability refers to the humeral head slipping out of the glenoid socket and causing symptoms. This is a relatively common abnormality in which the shoulder is considered to be the most unstable joint in the body (1). Back-ground: Pathological Abnormalities in Glenohumeral Instability: Ultrasonographic and MRI Correlations. In an unstable shoulder, many findings are possible. Each finding can occur alone or in combination with other lesions. These lesions include the Bankart lesion (85% of cases), Hill-Sachs lesion (77%), anterior glenoid rim damage (73%), capsular redundancy, subscapularis deficiency, and glenoid fossa deficiency. Absence of pathologic findings is also possible (4). Patients and Methods: Our study was performed on thirty patients with history of shoulder dislocation. All patients complained of shoulder dislocation either traumatic or non-traumatic. Exclusion criteria: Previous shoulder surgery, glenohumeral joint arthropathy, or substantial shoulder defects other than the sequelae of glenohumeral joint dislocation. Results: This study included 30 patients; 28 males, 2 females with age range from 18 years to 51 years (mean age 30 years, SD 11.9, mode 20 and median 26), suffering from symptoms of glenohumeral instability in the form of dislocation whether traumatic or non-traumatic associated with pain and/or limitation of movement. All of the 30 patients were examined with ultrasound and MRI’ and the MRI results were then compared with the collected data of US. Conclusion: We concluded that ultrasonography can be used as a screening method when there is any uncertainty, or when the issue of labral or capsular tear is not obvious from the clinical investigation, especially in hospitals that far or donot have MRI. However, MR allows accurate depiction of the size and location of labral tears and their associated capsular and glenohumeral ligament injuries and it is needed to evaluate the suspicious or negative Bankart or Perthes cases with ultrasound.
[Ali Abdelhady Elsayed, Mohammad Abo Elnaga Mohammad and Abdulaziz Ali Mohammad. Role of Ultrasonography and MRI Arthrography in Diagnosis of Glenohumeral Instability. Researcher 2018;10(7):9-15]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 2. doi:10.7537/marsrsj100718.02.

Keywords: Role; Ultrasonography; MRI; Arthrography; Diagnosis; Glenohumeral; Instability

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The Role of Mri Diffusion Weighted Images in Assessment of Cholesteatoma

Abdallah Mohammed El Kheshen1, Ali khalaf mahrous2, Hussien Montaser Roshdy1 and Hamza Mohammed Abd Elazem1

1Radio-Daiagnosis Department, Sayed Galal University Hospital, Faculty of Medicine, Alazhar University, Cairo, Egypt
2Otorhinolaryngology Department, Faculty of Medicine, Alazhar University, Cairo, Egypt
abdulaziz.oraby@gmail.com

Abstract: Background: CT is the primary tool for the evaluation of the extent and complications of middle ear cholesteatoma. However, it is inaccurate in differentiation of cholesteatoma from granulation or fibrous tissue as well as other middle ear pathologies e.g. cholesterol granuloma. MRI can be a beneficial tool in the confirmation or exclusion of cholesteatoma. Aim of the Work: The aim of work is to evaluate the role of MRI diffusion weighted images in the assessment of cholesteatoma. Patients and Methods: 30 patients with cholesteatoma suspected clinically or by CT examination or known patients with cholesteatoma with suspected post-operative recurrence were tested by MR thin cut multi-shot EPI diffusion weighted images of the skull base that were acquired by using a 1.5-T Achieva system in our department. Results: Our study revealed that the use of thin cut multi-shot EPI is a beneficial tool in the evaluation of both primary and recurrent cholesteatoma with excellent specificity that reduces the need of second look surgeries in multiple cases. It also revealed improved sensitivity and smallest detectable size compared to SS-EPI techniques. However, it shows relatively less sensitivity compared to non-EPI techniques with the smallest detectable size being about 4.5 mm. Conclusion: DWI is a beneficial tool in the evaluation of both primary and recurrent cholesteatoma with excellent specificity that reduces the need of second look surgeries in multiple cases. The use of multi-shot diffusion weighted techniques improved its sensitivity significantly compared to single shot techniques. It still could not detect lesions smaller than 4 mm.
[Abdallah Mohammed El Kheshen, Ali khalaf mahrous, Hussien Montaser Roshdy and Hamza Mohammed Abd Elazem. The Role of Mri Diffusion Weighted Images in Assessment of Cholesteatoma. Researcher 2018;10(7):16-20]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 3. doi:10.7537/marsrsj100718.03.

Key words: DWI, MRI, EPI, MS, SS, Cholesteatoma

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Design, Synthesis, and Biological Evaluation of New 5-Substituted-1,3,4-thiadiazole-2-thiols as Potent Antioxidants

Amgad M. Rabie*, Atif S. Tantawy, and Sahar M. I. Badr

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura City, 35516, Mansoura, Dakahlia Governorate, Egypt

*Corresponding Author: amgadpharmacist1@yahoo.com and pharm*org*chem1@mans.edu.eg

Abstract: A novel series of thirteen 5-substituted-1,3,4-thiadiazole-2-thiols (3a-m) was designed, synthesized, and evaluated for its potential antioxidant activities. Structural modifications at position 5 of the 1,3,4-thiadiazole scaffold (linked to a fixed antioxidant thiol group at position 2 of the ring) was expected to give new 1,3,4-thiadiazole derivatives with a broad spectrum of biological antioxidant activity. The synthesis of these new compounds was achieved through three different steps. Undoubted elucidation and confirmation of the chemical structures of all the newly synthesized compounds were accomplished using both the spectroscopic (IR, ¹H-NMR, and mass spectroscopy (MS)) and elemental (C, H, and N) analyses. The pharmacological screening for evaluation of the antioxidant activity of the new thirteen target thiol compounds was done using in vitro antioxidant screening by both 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation decolorization assay (ABTS test) and 2,2-diphenyl-1-picrylhydrazyl assay (DPPH test). The results of both assays showed that three compounds (3b,d,h) exhibited interestingly very high antioxidant activities and they could be very promising lead and parent compounds for the design and synthesis of new antioxidant agents by further in vivo biological evaluation, structural modifications, investigations, computational studies, and SAR establishment.

[Amgad M. Rabie, Atif S. Tantawy, and Sahar M. I. Badr. Design, Synthesis, and Biological Evaluation of New 5-Substituted-1,3,4-thiadiazole-2-thiols as Potent Antioxidants. Researcher 2018;10(7):21-43]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 4. doi:10.7537/marsrsj100718.04.

Keywords: 1,3,4-Thiadiazoles; Thiol moiety; Microwave-assisted synthesis; Reactive oxy (nitro)gen species; Free radical scavengers; Antioxidant activities

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Evaluation of Antiemetic Use in Pediatric Gastroenteritis in Damietta Governorate

Mohamed Yonis Madian, Salah Abdrabbou Elsaid, Mohamed Abdel Salam Zannoun

Pediatric Department, Faculty of Medicine, Al-Azhar University (Damietta Branch), Egypt

Mohammad1986yonis@gmail.com

Abstract: Background: gastroenteritis is a common pediatric health problem. Antiemetics are frequently prescribed, irrespective of the absence of guideline recommendations to support this practice. Aim of the work is to review the use of antiemetics for pediatric AGE and to define prescribing patterns of physicians. Methodology: 100 physicians from Damietta were included in the present study. They were 77 pediatricians, 20 general practitioners and 3 emergency physicians. All physicians completed a standardized written questionnaire. The questionnaire included certification, frequency of gastroenteritis diagnosis at the last month and pattern of and response to antiemetics. In addition, any adverse effects or limiting factors for antiemetics use were recorded. Results: 90% of physicians prescribed antiemetic in the last month; 93% did not have any concern with prescription; 42% do not prescribe antiemetic below certain age (6 months by 27%); 36% noted adverse effects and 99% prefer parenteral route. Most physicians prefer ondansetron as first choice. Metoclopramide was reported as first choice by emergency (33%) and general practitioners (15%) more than Pediatricians (only 3%), with significant difference. In addition, ondansetron was reported to participate in recovery from vomiting other than other antiemetics. Metoclopramide was reported to share recovery from vomiting by GPs (25%) and emergency physicians (33%) more than Pediatricians (6.5%), with significant difference. Conclusion: Antiemetics are frequently used by all physicians of Damietta governorate included in the present work for treatment of vomiting in pediatric gastroenteritis. Ondansetron is the first choice, and metoclopramide is used by general practitioners and emergency doctors more than Pediatricians.

[Mohamed Yonis Madian, Salah Abdrabbou Elsaid, Mohamed Abdel Salam Zannoun. Evaluation of Antiemetic Use in Pediatric Gastroenteritis in Damietta Governorate. Researcher 2018;10(7):44-49]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 5. doi:10.7537/marsrsj100718.05.

Keywords: Acute gastroenteritis; antiemetics; ondansetron; metoclopramide

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Aging Effect on Marginal Gap Distance and Cyclic Loading of Two Different Ceramic Crowns

Prof. Dr. Cherif Adel Mohsen and Mostafa Elhussieny Mohammed Ismail

Fixed Prosthodontics Department, Faculty of Dentistry, Minia University, Egypt.
dentist_mostafa@hotmail.com

Abstract: This study was carried out to evaluate and compare the vertical marginal gap distance, and cyclic loading of all-ceramic crowns Vita suprinity and IPs e.max CAD (CAD/CAM milling, Cerec MCXL), using two types of finish lines (deep chamfer and radial shoulder). Specially designed stainless steel dies were constructed and a total number of 40 samples were constructed representing two equal groups (20 samples), according to the type of materials (VITA Suprinity and IPs E.max CAD “CAD/CAM milling technique Cerec MCXL) The twenty samples were further divided into two divisions (10 each) according to the type of the finish line used (deep chamfer and radial shoulder). Each division was then divided into two classes (5 each) (one class was constructed as a crown coping and then veneered, the second one was constructed as a full contoured crowns). Vita suprinity and IPs e.max CAD crowns were fabricated following a standard procedure and standard dimensions as controlled by the Cerec MCXL software. As regard the vertical marginal gap test, the results showed that IPs e.max CAD crowns regardless to finish line type and veneering, recorded a higher vertical marginal gap mean value (42.59±2.38 µm) than obtained with Vita Suprinity crowns (36.11±1.76µm). Regardless to the production techniques and veneering, deep chamfer finish line recorded a lower vertical marginal gap mean value (37.94±2.11µm) than obtained with radial shoulder finish line (40.77±2.33µm). Regardless to production techniques and finish lines, full contoured crowns recorded a lower vertical marginal gap mean value (38.34±2.36µm) than obtained veneering (40.36±2.10µm). The cyclic loading test data revealed that IPs e.max CAD crowns recorded a higher fracture resistance mean value (1013±53.84N) than the load cycled crowns (888.1±104.4N). Vita suprinity crowns recorded a higher fracture resistance mean value (803.7±66.45N) than the load cycled crowns (703.8±34.26N), regardless to finish line type and veneering. The cyclic loading test data revealed that IPs e.max CAD crowns recorded a higher fracture resistance mean value (1013±53.84N) than the load cycled crowns (888.1±104.4N). Vita suprinity crowns recorded a higher fracture resistance mean value (803.7±66.45N) than the load cycled crowns (703.8±34.26N), regardless to finish line type and veneering.
[Cherif Adel Mohsen and Mostafa Elhussieny Mohammed Ismail. Aging Effect on Marginal Gap Distance and Cyclic Loading of Two Different Ceramic Crowns. Researcher 2018;10(7):50-56]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 6. doi:10.7537/marsrsj100718.06.

Keywords: IPS e-max CAD, Vita Suprinity, Marginal gap, Cyclic loading, All ceramic restoration and Cerec Mcxl

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Effects of oil pollution on Aquatic Organism (Review Article)

Mona S. Zaki1; Mohammad M. N. Authman1; Mostafa F. Abdel Zaher1 and Olfat M. Fawzi2

1Hydrobiology Department, Veterinary Division, National Research Centre, Egypt.
2Biochemistry Department, National Research Centre, Egypt.
dr_mona_zaki@yahoo.co.uk

Abstract: Oil pollution has become a global environmental issue in that oceanic ecosystems and inland aquatic ecosystems are threatened greatly. The evaluation and prediction of the effects of oil pollution on water environment have become a very urgent and important issue. It has been estimated that approximately 5 million tons of crude oil enters the marine environment each year from a variety of sources mostly known are the spills from shipwreck, but there are several less conspicuous sources, like intentional flushing of ship compartments, spills from oil rigs, oil from industries, oil refineries, run-off from urban areas.
[Mona S. Zaki; Mohammad M. N. Authman; Mostafa F. Abdel Zaher and Olfat M. Fawzi. Effects of oil pollution on Aquatic Organism (Review Article). Researcher 2018;10(7):57-60]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 7. doi:10.7537/marsrsj100718.07.

Key words: Oil pollution– PAHs Toxicological effects

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Epidemiological Distribution of Animal and Human Rabies in Ethiopia Based on Previous Reports

Gudeta Mojo Hawas¹, Usman Lelo Kebeto², Temesgen Tadesse Yitayih³

¹ Addis Ababa University College of Veterinary Medicine

² Paradise Valley University College, Department of Animal Health, Shashemene, Ethiopia

³ National Disaster Risk Management Commission, Addis Ababa, Ethiopia

Telephone: +251921726339; E-mail: gudetajambo.edu.aau@gmail.com

Abstract: Rabies is a viral disease that affects all warm blooded animals including humans and is common in many geographical locations of the world including Ethiopia. It is distributed all over the world affecting about 100 countries with more than 2.5 billion population except some rabies free island states like UK, Japan and some developed states like Spain, Portugal, Sweden, Finland, Norway, Greece, and some others. The most affected countries of the world are found in tropical Africa, Asia, South America, and Oceania. It is a subject of concern mainly because of its zoonotic importance. An estimated 50,000 to 60,000 humans die from rabies every year. Most of the deaths due to rabies occur in developing countries where canine rabies is endemic and dog biting is the main mode of transmission. Rabid Dogs are the major vectors responsible for the spread and transmission of rabies to humans and other animals in Ethiopia. The situation of rabies and the public’s knowledge, attitude and practice (KAP) were studied and reported from different parts of the country including from North Gondar zone, Addis Ababa, Jimma town, Gomma district of south west of Ethiopia, Bahir Dar town and eastern Ethiopia of the Awash Basin. The current scenario in Ethiopia shows a serious threat of canine rabies virus transmission in the rapidly growing human population where a poorly controlled stray dog population is equally growing fast. Poor public awareness among the public towards rabies is considered as one of the bottle necks for the prevention and control of the disease in Ethiopia especially in canine rabies endemic cities. There is huge gap in knowledge, attitude and practice of the Ethiopian society with slight variability between regions, the least level of awareness being seen in pastoral community. The failure to receive PEP was a major factor in the number of human cases in Ethiopia. The study shows high canine rabies burden, and lack of sufficient awareness about the disease and high reliance on traditional treatment that interfere with timely post exposure management. Providing subsidized rabies vaccines for dogs and PEP treatment for humans is essential to improve coverage and utilization of modern, scientifically proven and effective rabies control methods especially for poor rural farming and pastoral communities. The practice of traditional healers must be closely scrutinized and scientifically tested for efficacy

[Gudeta Mojo Hawas, Usman Lelo Kebeto, Temesgen Tadesse Yitayih. Epidemiological Distribution of Animal and Human Rabies in Ethiopia Based on Previous Reports. Researcher 2018;10(7):61-71]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 8. doi:10.7537/marsrsj100718.08.

Keywords: Attitude, Distribution, Ethiopia, History, Knowledge, Practice, Rabies

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Relation between Beta and Gamma function By using Laplace transformation

Dr. Dinesh Verma

Associate Professor

Yogananda College of Engineering & Technology, Jammu

Email: drdinesh.maths@gmail.com

Abstract: Normally it has been noticed that differential equation is solved typically. The Laplace transformation makes it easy to solve. The Laplace transformation is applied in different areas of science, engineering and technology. The Laplace transformation is applicable in so many fields. Laplace transformation is used in solving the time domain function by converting it into frequency domain. Here we have applied Laplace transformation in linear ordinary differential equations with constant coefficient and several ordinary equations wherein the coefficients are variable. Laplace transformation makes it easier to solve the problems in engineering applications and makes differential equations simple to solve. In this paper we will discuss the relation between beta and gamma function by using Laplace transformation.

[Dinesh Verma. Relation between Beta and Gamma function By using Laplace transformation. Researcher 2018;10(7):72-74]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 9. doi:10.7537/marsrsj100718.09.

Key words: Laplace transformation, Inverse Laplace transformation, beta function, gamma function, convolution theorem.

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Review on Salmonellosis

Tsehaye Neges and Wudalew Abebe

Graduates of Veterinary Medicine, Collage of Veterinary of Medicine and Animal Sciences, University of Gondar, Ethiopia, P.O. Box. 196.

Email: thesunneges@gmail.com

Abstract: Salmonellosis is an infectious disease of humans and animals caused by organisms of the two species of Salmonella (Salmonella enterica, and S. bongori). Although primarily intestinal bacteria, and widespread in the environment and commonly found in farm effluents, human sewage and in any material subject to fecal contamination. Salmonellosis can be found worldwide but seems to be most common where intensive animal husbandry is practiced. Reservoirs also remain in wild animals. Some Salmonella are geographically limited. Salmonella species are transmitted via the fecal-oral route. The most common mode of transmission is ingestion of food or water that has been contaminated with human or animal feces thus; infection remains a distressing public health concern worldwide. The genetic make-up of the Salmonella strains permits their adaptation in various environments, including human, animal and non-animal hosts. This increases the difficulty in eliminating the bacteria. The emergence of antimicrobial resistance in Salmonella strains is a serious health problem worldwide, Moreover, these multidrug resistant (MDR) Salmonella strains poses a great challenge in terms of effective treatment of the infections caused by these strains. Several preventive measures have been proposed to stop the spread of Salmonella infection, like proper food and water sanitation, pasteurization of milk and other dairy products, and elimination human faces in the food production these, restriction of indiscriminate use of antibiotics in food animals is by far one of the most effective measures. The objective of this paper was to review on the epidemiology and zoonotic implication of Salmonella in human, as well the mechanisms of resistance of Salmonella for antimicrobial drugs.

[Tsehaye Neges and Wudalew Abebe. Review on Salmonellosis. Researcher 2018;10(7):75-85]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 10. doi:10.7537/marsrsj100718.10.

Key words: Antibiotic, Public health, Salmonella

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Study on Hyperlipidemia in Donkeys with Special Reference to Its Therapeutic Approach And Ameliorative Measures in And Around Gondar Town

Abebe Mequanent ¹, Shamsul Haque¹, Birhanu Ayele ², Girma Birhan ²

¹ University of Gondar College of Veterinary Medicine and Animal Science, Department of Veterinary Clinical Medicine, Gondar, Ethiopia, P.O. Box: 196.

² University of Gondar College of Veterinary Medicine and Animal Science, Department of Veterinary Paraclinical studies

E-mail: abebemequanent@gmail.com

Abstract: Hyperlipidemia is the presence of elevated lipid concentrations in the blood and it is associated with many predisposing factors. Clinical field trial was conducted from January 2017 to April, 2018, to determine the most effective therapeutics for treatment of hyperlipidemia in donkeys by ensuring the efficacy of different concentrations and combination of dextrose. For this study, 15 adult male donkeys were selected in the study area, after performing tentative diagnosis, screening test and confirming by laboratory biochemical tests. Randomly assigned 15 animals in the first, second, third and fourth groups with equal number of 3 were subjected to treatment with dextrose 5% plus prednisolone 5mg, dextrose 5%, dextrose 10% and dextrose 20% respectively and the fifth group was positive control. Blood samples were collected from jugular vein of donkeys, before and after treatment. Hemoglobin concentration, packed cell volume, white blood cells and red blood cells count were evaluated using automated hemoanalyzer in all selected animals. Plasma was tested for total proteins, albumin, triglycerides (TG), total cholesterol, ALT, AST activity and glucose level. Heart rate, respiratory rate and rectal temperature were also evaluated. General health of animals and abnormal clinical signs were recorded daily. ANOVA was used to test the efficacy of dextrose between and within groups and paired t-test were used to test efficacy of dextrose before and after treatment. When animals were hyperlipidemic significantly increased of mean plasma ALT, AST, Triglyceride (TG) and total cholesterol level were observed and significantly decreased in total protein, glucose and albumin, when compared with normal baseline values. But when animals were treated with dextrose intravenously in different concentrations and combination, especially diseased animals were treated with dextrose 5% plus prednisolone 5mg, the plasma ALT, AST, Triglyceride (TG) and total cholesterol level were significantly decreased to normal level and total protein, glucose and albumin, increased significantly to normal values. Diseased animals which were treated with dextrose 5% alone had a good response next to its combination with prednisolone. Diseased animals were treated with dextrose 10% and 20% had no significant change and the better drug (dextrose 5% plus prednisolone 5mg) recommended to government and private veterinary practitioners for the treatment of hyperlipidemia disease conditions.

[Abebe Mequanent, Shamsul Haque, Birhanu Ayele, Girma Birhan. Study on Hyperlipidemia in Donkeys with Special Reference to Its Therapeutic Approach And Ameliorative Measures in And Around Gondar Town. Researcher 2018;10(7):86-95]. ISSN 1553-9865 (print); ISSN 2163-8950 (online). http://www.sciencepub.net/researcher. 11. doi:10.7537/marsrsj100718.11.

Key words: Ameliorative measures, donkey, hyperlipidemia and therapeutic regimens

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