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Cancer-associated Fibroblasts Promote Mouse's Breast Cancer Cells to Form Cellular Aggregates in Soft Agar Culture Medium

Xiangnan Zhang¹, Shuo Liang², Ning Tao^{3, *}

¹ Beijing Niulanshan First Secondary School, China

² Beijing Dayu School, China

³ Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

^*Corresponding author. Institute of Biophysics, Chinese Academy of Sciences, No. 15 Datun Road, Chaoyang Area, Beijing City, China. Email address: tao@ibp.ac.cn

Abstract: Cancer-associated fibroblasts (CAFs) can promote cancer cell growth, invasion and migration. However, few co-culture methods are able to be used to build a model in vitro, which can simulate these two sorts of cells’ crosstalk in vivo in all directions. In this research, we successfully made mixed mouse’s breast cancer cells (TS/A) and stellate cells of human liver that are induced by TS/A and gained the characteristic of CAFs (ME-iLX-2) form globular cellular aggregates in soft agar culture medium. In addition, we demonstrated that CAFs can promote forming of the aggregates. What’s more, we proved eugenol’s suppression of TS/A-ME-iLX-2 aggregates, which indicates that this model can be expected to be used in screening of anticancer drugs.

[Xiangnan Zhang, Shuo Liang, Ning Tao.^.Cancer-associated Fibroblasts Promote Mouse's Breast Cancer Cells to Form Cellular Aggregates in Soft Agar Culture Medium. Cancer Biology 2022;12(1):1-7]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net 1. doi:10.7537/marscbj120122.01.

Key Words: Cancer-associated Fibroblast, Breast Cancer Cell, Soft Agar Culture, Cellular Aggregate

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Performance, Serum Biochemical And Haematological Response Of Broiler Chicken Fed Mixture Of Ginger (Zingiber Officinale) And Garlic (Allium Sativum) In Diets

¹Umoru, J. I. A. and ²Agbaye F. P.

¹Federal College of Education (Technical) Akoka, Lagos

²Lagos State Polytechnic, Ikorodu, Lagos.

Abstract: Performance, serum biochemical and haematological response of broiler chicken fed mixture of ginger (Zingiber officinale) and garlic (Allium sativum) in diets was investigated in a feeding trials using completely randomised design that lasted for eight weeks. A total of 135 1-day broiler chicks of Abor acre strain were randomly allotted to three dietary treatments of 45 chicks per treatment and replicated 15 chicks per treatment Three isocaloric and isonitrogenous diets were formulated and fed. Control diet was without mixture of ginger and garlic. The two other diets were T₁ 7.5g Ginger plus 7.5g Garlic mixture/25 kg diet and T₂ 15g Ginger plus 15g Garlic mixture/25 kg diet. The experimental diets were offered to the respective birds with water ad libitum. The body weight gain (Kg) feed intake and feed conversion ratio (FCR) of birds control, T₁ and T₂ respectively were similar (p> 0.05). Birds on diet. T₂ recorded the highest live ability percentage (96 Mixture of ginger and garlic in ratio 1:1 up to 7.5 g each in 25 kg diets slightly but insignificantly (p>0,05) increased performance body weight gain and live ability improved feed conversion ratio (FRC) but reduced feed intake. Variation in the experimental diets had no significant (p>0.05) difference on serum biochemical and haematological indices except for Glucose and Alkaline Phosphate, and White Blood Cell count Lymphocytes and Basophil which showed significant (p<0.05) difference with the level mixture of ginger and garlic ip diets. Mixture of ginger and garlic in the diets of broiler chicken had no adverse effect on the serum biochemical and haematological indices.

[Umoru, J. I. A. and  Agbaye F. P. Performance, Serum Biochemical And Haematological Response Of Broiler Chicken Fed Mixture Of Ginger (Zingiber Officinale) And Garlic (Allium Sativum) In Diets. Cancer Biology 2022;12(1):8-12]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  2.doi:10.7537/marscbj120122.02.

Keywords: performance body weight, serum biochemical and haematological indices, Allium sativum, Zingiber officinale

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Prognostic value of the inflammatory markers derived from peripheral blood cell counts in gallbladder cancer

Walid Elmoghazy^1,2, Rassoul Abu-Nuwar¹, Ibnouf Sulieman¹, Ammar Aleter¹, Samah Mohamed^3,4, Ahmed Elaffandi^1,5, Hatem Khalaf¹, Alshimaa Alaboudy⁶

¹Department of Surgery, Organ Transplant Section, Hamad Medical Corporation, Doha, Qatar

²Department of Surgery, Sohag University, Sohag, Egypt

³Diagnostic Radiology, Hamad Medical Corporation, Doha, Qatar

⁴Diagnostic Radiology, National Cancer Institute, Cairo, Egypt

⁵Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt

⁶Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University, Sohag, Egypt

moghazyw@gmail.com, rassoul87@hotmail.com, ibnouf_s@hotmail.com, AAleter@hamad.qa, saffandy2000@yahoo.co.uk, ahmedaffandy@gmail.com, hatem@khalaf.us, alaboudysh@gmail.com

Abstract: Objective: To study the potential predictors of patient survival, including the inflammatory markers derived from peripheral blood cell counts, in gallbladder cancer. Patients and methods: This study included patients diagnosed with gallbladder cancer and have follow up of at least 6 months. Patients who had cholangitis at diagnosis were excluded. The ratios of neutrophil to lymphocyte counts (NLR), platelet to lymphocyte counts (PLR), and monocyte to lymphocyte counts (MLR) were calculated at the time of diagnosis. Results: A total of 85 patients fulfilled the criteria and were involved in the analysis between July 2009 and January 2020. Thirty-five patients (41%) were females, and 50 (59%) were males. The mean age at the time of diagnosis with gallbladder cancer was 54 ± 12 years, and it ranged from 31 to 93 years. The mean follow-up period was 1.0 ± 0.7 years. Patient survival from the time of diagnosis until the last follow-up was 44.7%, with 47 patients died during the follow-up period; the median survival was 1.5 years. Cox's proportional hazard regression analyses were carried out and revealed that young age at diagnosis (HR=1.04, CI=1.01-1.07), PLR≤200 (HR=0.35, CI=0.17-0.70), and surgical resection (HR=0.10, CI=0.04-0.23) are associated with longer survival. Conclusion: Platelet/lymphocyte ratio can be a valuable and straightforward prognostic marker of gallbladder cancer.

[Walid Elmoghazy, Rassoul Abu-Nuwar, Ibnouf Sulieman, Ammar Aleter, Samah Mohamed, Ahmed Elaffandi, Hatem Khalaf¹, Alshimaa Alaboudy Prognostic value of the inflammatory markers derived from peripheral blood cell counts in gallbladder cancer .Cancer Biology 2022;12(1):13-19]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  3.doi:10.7537/marscbj120122.03.

Keywords: Gallbladder, Malignancy, Outcome, Prognostic factors, Inflammatory markers, Survival

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Effect of Submucosal Resection and Submucosal Diathermy on Nasal Airflow in Inferior Turbinate Hypertrophy

Mohammad Reza Niyousha ¹, Samad Ghiasi ², Kamyar Ghabili ³, Amir Mohammad Bazzazi ⁴, Elnaz Mousavi ⁵

^1. Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

^2. Department of Otolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran

^3. Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

^4. Department of Neurosurgery, Urmia University of Medical Sciences, Urmia, Iran

^5. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

kghabili@gmail.com

Abstract: Submucosal resection and submucosal diathermy are common procedures in the treatment of inferior turbinate hypertrophy. Nonetheless, there is still a debate on the safety and efficacy between these two surgical techniques. We aimed at comparing the effectiveness and safety of submucosal diathermy and submucosal resection in the treatment of inferior turbinate hypertrophy. Sixty patients with nasal obstruction due to inferior turbinate hypertrophy were randomly divided into two groups; submucosal resection and submucosal diathermy groups. Gertner-Podoshin plate was used for measurement of nasal airflow before operation and 2 months postoperative. Significant resolution of the obstruction reported by the patients was similarly detected in diathermy (93.1%) and resection groups (96%, P>0.05). According to the Gertner-Podoshin measurements, both diathermy and resection techniques similarly resulted in good nasal airflow two month postoperative (86.2% vs. 89.2%, respectively; P>0.05). Postoperative bleeding was more common in the resection group compared with the diathermy group (P=0.002). Moreover, patients in the diathermy group suffered from pain more than the resection group (P=0.01). Both submucosal resection and submucosal diathermy techniques result in similar postoperative outcomes in treatment of inferior turbinate hypertrophy, although postoperative bleeding and pain was more in submucosal resection and submucosal diathermy techniques, respectively.

[Niyousha MR, Ghiasi S, Ghabili K, Bazzazi AM, Mousavi E. Effect of submucosal resection and submucosal diathermy on nasal airflow in inferior turbinate hypertrophy. Cancer Biology 2022;12(1):20-23]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  4. doi:10.7537/marscbj120122.04.

Keywords: Inferior turbinate hypertrophy; submucosal resection; submucosal diathermy; nasal airflow; side effects

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Cancer Cell Research Literatures

Mark Herbert, PhD

World Development Institute

39 Main Street, Flushing, Queens, New York 11354, USA, ma8080@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports as references in the related studies.

[Mark Herbert, PhD. Cancer Cell Research Literatures. Cancer Biology 2022;12(1):24-81]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  5. doi:10.7537/marscbj120122.05.

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Cancer and SRISPR-Cas9 Research Literatures

Mark Herbert, PhD

World Development Institute

39 Main Street, Flushing, Queens, New York 11354, USA, ma8080@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports as references in the related studies.

[Mark Herbert, PhD.Cancer and SRISPR-Cas9 Research Literatures. Cancer Biology 2022;12(1):82-100]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  6. oi:10.7537/marscbj120122.06.

Key words: cancer; SRISPR-Cas9; life; research; literature; cell

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Cancer Signs and Symptoms Research Literatures

Mark Herbert, PhD

World Development Institute

39 Main Street, Flushing, Queens, New York 11354, USA, ma8080@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports as references in the related studies.

[Mark Herbert, PhD. Cancer Signs and Symptoms Research Literatures. Cancer Biology 2022;12(1):101-119]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  7. doi:10.7537/marscbj120122.07.

Key words: cancer; signs and symptoms; biology; life; research; literature; cell

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Cancer and Tumor Biology Research Literatures

Mark Herbert, PhD

World Development Institute

39 Main Street, Flushing, Queens, New York 11354, USA, ma8080@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports as references in the related studies.

[Mark Herbert, PhD. Cancer and Tumor Biology Research Literatures. Cancer Biology 2022;12(1):120-131]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  8. doi:10.7537/marscbj120122.08.

Key words: cancer; tumor; life; research; literature; cell

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