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Vitamin D₃ and Risk of Uterine Fibroid-Effect of Vitamin D₃ as A Medical Management of Uterine Fibroid

Wael Ahmed Ezzat Kamel Ammar¹, Emad Abd El Rahman EL Tamami², Fahd Abd El Aal Mohammed El Omda², Mohammed Ibrahim Mostafa El Mohandes³ and Ahmed Abd El Fatah Taha⁴

¹Assistant Fellow and Assistant Specialist of Obstetrics and Gynecology. El Galaa Maternity Teaching Hospital. Egypt.

²Professor of Obstetrics and Gynecology. Faculty of Medicine, Al Azhar University, Egypt.

³Consultant of Obstetrics and Gynecology. El Galaa Maternity Teaching Hospital. Egypt.

⁴ Assistant Professor of Obstetrics and Gynecology. Faculty of Medicine, Al Azhar University, Egypt.

dr.waela3@gmail.com

Abstract: Objective: To evaluate possible relation between serum vitamin D₃ deficiency and the uterine fibroid disease and to assess the effect of vitamin D₃ administration as a medical management on growth of uterine fibroid. Patient and methods: This study was prospective case-control study done from October 2015 to October 2017 in Al Galaa Maternity Teaching Hospital. It Included 55 women their age between 20: 45 years divided into 2 groups: Group A: (control group): 25 women without fibroid or other medical disease, and Group B: (study group): 30 women with fibroid then group B divided in to two subgroups: Subgroup B1: 15 women of study group who had vitamin D deficiency received medical treatment with Vitamin D for 3 months. And Subgroup B2: The other 15 women of study group did not receive vitamin D. We measured serum vitamin D in all women (group A and group B) at start of the study. Both subgroups B1 and B2 were followed by transvaginal 2 D ultrasound for assessment of fibroid size by measurement the mean fibroid size which is the sum of two largest perpendicular diameters then divided by two. This assessment of fibroid done for both subgroups B1 and B2 at start of the study and after 6 months from the start of study to know the average change in fibroid size within 6 months with and without treatment by vitamin D. Results: The women of control group their mean serum vitamin D was 10.90 ± 0.48 ng/mL, While the women of the study group their mean serum vitamin D was 5.79 ± 2.60 ng/mL, Where P value was less than 0.05 so was considered statistically significant. While the difference in the mean fibroid size at start of study and after 6 months in both subgroup B1 and subgroup B2 both were statistically not significant (P value ˃ 0.05). Conclusion: There was a significant association between sever serum vitamin D deficiency and existence of fibroids. But there was no association between size of fibroid and vitamin D administration.

[Wael Ahmed Ezzat Kamel Ammar, Emad Abd El Rahman EL Tamami, Fahd Abd El Aal Mohammed El Omda, Mohammed Ibrahim Mostafa El Mohandes and Ahmed Abd El Fatah Taha. Vitamin D₃ and Risk of Uterine Fibroid-Effect of Vitamin D₃ as A Medical Management of Uterine Fibroid. Nat Sci 2018;16(3):1-5]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 1. doi:10.7537/marsnsj160318.01.

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Evaluating the antidiabetic effect of Turmeric extract on streptozotocin induced Diabetic rats

Ashfa Ghani^*, Eman Manzoor, Aniza Ishaque, Runa Khan, Noman Nawaz, Hafiz Muhammad Aaqib Saeed, Ali Ahmad Leghari

National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.

*Corresponding author’s email: ashfaghani@yahoo.com

Abstract: Diabetes is a major risk factor for coronary artery diseases, nephropathy, neuropathy, retinopathy and many other complications. Turmeric and its bioactive compounds like curcumin had great therapeutic abilities against diabetes. In this study turmeric and its extract was evaluated for its hypoglycemic potential in streptozotocin induced hyperglycemic rats for thirty days. For this purpose, turmeric extract obtained was analyzed for its antioxidant potential via screening tests like DPPH, TPC. The best result for TPC was seen with concentration of 70% of ethanolic extract gives the best result for TPC and its total phenolic content was 536.56 ± 2.24 mg GAE/100mg followed by methanolic extract at the concentration of 70% gives the TPC value 529.62 ±6.56 GAE/100mg and from acetone the best extraction percentage was also 70 % and its TPC value was 524.94 ± 1.54. The maximum DPPH value was seen with ethanolic extract at concentration of 70% 59.58 ±2.89 At the end of the study turmeric extracts administrated rats was kept fasted overnight and then it was analyzed for their glucose, insulin. For insulin the maximum effect was seen with ethanolic extract 11.30b±0.04. The ethanolic extract at the concentration of 70% cause maximum decrease in blood glucose level.

[Ashfa Ghani, Eman Manzoor, Aniza Ishaque, Runa Khan, Noman Nawaz, Hafiz Muhammad Aaqib Saeed, Ali Ahmad Leghari. Evaluating the antidiabetic effect of Turmeric extract on streptozotocin induced Diabetic rats. Nat Sci 2018;16(3):6-12]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 2. doi:10.7537/marsnsj160318.02.

Key words: TPC (total phenolic contents), Thiobarbituric acid reactive substances (TBARS), Diabetes

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Nasal valve Surgery (Different Surgical Techniques)

Prof. Dr. Atef Abdullah El Maraghy, Prof. Dr. Mohammed Ali Ahmed, Prof. Dr. Salah Eldine Saaeed, Prof. Dr. Abd El Aziz Kamal Saad, Ass. Prof. Dr. Ahmed Gad and Mo’men Ebrahim Mohammed Ali

ENT Department, Faculty of Medicine, Al-Azhar University, Egypt

drmomenorl2003@gmail.com

Abstract: Different surgical technique used for treatment of nasal valve collapse. 30 patients had been under surgical management divided into three groups according to surgical intervention; spreader graft, cartilage spanning graft and splay conchal graft. It evaluates the three techniques However, the small number of patients included in each group, especially the second and third groups represented a limiting step against globalization of results obtained in the present study. The spreader graft technique provided the better outcome.

[Atef Abdullah El Maraghy, Mohammed Ali Ahmed, Salah Eldine Saaeed, Abd El Aziz Kamal Saad, Ahmed Gad and Mo’men Ebrahim Mohammed Ali. Nasal valve Surgery (Different Surgical Techniques). Nat Sci 2018;16(3):13-43]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 3. doi:10.7537/marsnsj160318.03.

Key words: nasal valve collapse, spreader graft, splay conchal graft, cartilage spanning graft, acoustic rhinometry.

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Standardization of growing substrates to produce quality cut Lilium under agro-climatic conditions of Faisalabad, Pakistan.

Muhammad Danish¹, Kamran Sabar^1*, Muhammad Arsalan Manzoor¹, Hafiz Muhammad Asif Maqbool¹, Hafiz Amir Iqbal¹, Amjad Hussain¹, Touqeer Haidar¹, Ahmad Bilal².

¹Institute of Horticultural Sciences, University of Agriculture, Faisalabad, Pakistan.

²Institute of Business Management sciences, University of Agriculture, Faisalabad, Pakistan.

*Corresponding author’s email: kamransabir2010@gmail.com

Abstract: The research work presented in this dissertation was carried out at Rose Project Research Area, Institute of Horticultural Sciences, University of Agriculture, Faisalabad, during 2015- 2016 to evaluate comparative efficacy of various substrates on vegetative and reproductive growth of Asiatic Lilium hybrid L. ‘Vermeer’ for cut flower production. Soilless substrates are increasingly used to produce cut flowers of superior quality. Nutritional status and standardization of growing substrate is of prime importance for the quality production of cut flowers. Cut Lilium production is gaining momentum in Pakistan, but growers are unaware of advanced production systems and techniques for best quality flower production. Moreover, very limited work has been reported so far on efficacy of various organic substrates for cut Lilium production in the country. Therefore, keeping in view above mentioned characteristics, an experiment was conducted using coco coir, mushroom compost and conventional medium alone or in various combinations as growing substrates. Substrates were mixed by volume and filled in wooden crates after lining with polythene sheet and making small holes for drainage as per following treatments, viz. Soil + Silt (Control) (1:1, v/ v), Mushroom Compost, Coco Coir, Silt + Mushroom Compost (1:1; v/ v), Silt + Coco Coir (1:1; v/ v), Mushroom Compost + Coco Coir (1:1; v/ v) and Silt + Mushroom Compost + Coco Coir (1:1:1; v/ v/ v). The experiment was laid out in a completely randomized design (CRD) with seven treatments. Each treatment was replicated thrice having twelve plants per replication. The objectives of this study were to standardize growing substrates to produce best quality cut Lilium and to evaluate suitability of coco coir and or mushroom compost in comparison to traditionally used soil/silt for flower production under agro- climatic conditions of Faisalabad. Result concluded that plants grown with coco coir alone and in combination with soil + silt had best performance regarding most of the parameters studied. Therefore, growers may use coco coir alone or mixed with soil/ silt for better growth and superior quality stem production of cut Asiatic Lilium.

[Muhammad Danish, Kamran Sabar, Muhammad Arsalan Manzoor, Hafiz Muhammad Asif Maqbool, Hafiz Amir Iqbal, Amjad Hussain, Touqeer Haidar, Ahmad Bilal.. Standardization of growing substrates to produce quality cut Lilium under agro-climatic conditions of Faisalabad, Pakistan.. Nat Sci 2018;16(3):44-55]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 4. doi:10.7537/marsnsj160318.04.

Key words: Cut flowers, ‘Vermeer’ Lilium, agro- climatic

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The Potential Use of Atorvastatin Calcium/Hydroxypropyl-Β-Cyclodextrincomplex loaded Hydrogel as an Ocular Delivery System.

Germeen N.S. Girgis, Mariza F. Boughdady, and Noha M. Saleh

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt

nunu_ramy@yahoo.com

Abstract: Objectives: The aim was to prepare and evaluate ophthalmic hydrogels containing atorvastatin calcium/hydroxypropyl-β-cyclodextrincomplex (ATSCa/HP-β-CyD). ATSused for atherosclerosis, was proved to have therapeutic effects on intraocular inflammation and uveoretinitis but its poor water solubility hinderedits ocular application. Methods: First, complexes were prepared and characterized by different techniques. Different polymers (sodium alginate, carbopol934, and methylcellulose) were selected to formulate hydrogels containing either free or complexed drug. Physical and in-vitro release characteristics were studied. Key findings: The complexes showed improved dissolution rates compared to untreated drug; highest dissolution rate was observed in co-solvent and common solvent methods. Hydrogels were, clear with acceptable pH and drug content except sodium alginate was slight turbid. The results showed that there was increase in the drug percent released from carbopol934 or methylcellulose loaded with the complexed drug compared to the corresponding ones with free drug. On the other hand, percentages released from sodium alginate gels were decreased by complexation. Conclusions: Ophthalmic carbopol934 gels containing ATS Ca/HP-β-CyD complex are considered promising delivery systems with the highest in-vitro drug release profile.

[Germeen N.S. Girgis, Mariza F. Boughdady, and Noha M. Saleh. The Potential Use of Atorvastatin Calcium/Hydroxypropyl-Β-Cyclodextrincomplex loaded Hydrogel as an Ocular Delivery System.. Nat Sci 2018;16(3):56-65]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 5. doi:10.7537/marsnsj160318.05.

Keywords: Atorvastatin calcium, HP-β-CyD, ophthalmic hydrogels, polymer.

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Comparative Study between Mini Laparoscopic and Conventional Laparoscopic Cholecystectomy

Ahmed Salama Sayouh, Mohammed Alsayed Mera and Bahaa El-Din Hassan Ibrahim Shanab

General surgery Department, Faculty of Medicine, Al-Azhar University, Egypt

drmohamedphys@gmail.com

Abstract: Background: The use of laparoscopy has gained widespread popularity in surgical approaches to abdominal wall hernias and intestinal and solid organ resection. However, no other operation has been as profoundly affected by the advent of laparoscopy as cholecystectomy. Objective: Comparison between Mini Laparoscopic Cholecystectomy (MLC) and conventional laparoscopic cholecystectomy (CLC) as regard: Mean operative time, difficulty of operation, severity of postoperative pain, postoperative complications, cosmetic appearance and patient satisfaction for the operation. Materials and Methods: 100 patients; 50 of them subjected to Mini Laparoscopic Cholecystectomy. and 50 subjected to conventional laparoscopic cholecystectomy. Results: mini-laparoscopic cholecystectomy better than laparoscopic. Mini Laparoscopic Cholecystectomy patients reported significantly lower pain score 24 hours postoperatively and a shorter convalescence. Conclusion: Mini Laparoscopic and Conventional Laparoscopic Cholecystectomy are feasible and safe options for mini-invasive cholecystectomy.

[Ahmed Salama Sayouh, Mohammed Alsayed Mera and Bahaa El-Din Hassan Ibrahim Shanab. Comparative Study between Mini Laparoscopic and Conventional Laparoscopic Cholecystectomy. Nat Sci 2018;16(3):66-70]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 6. doi:10.7537/marsnsj160318.06.

Keywords: Laparoscopy, Cholecystectomy

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Subsurface Interpretation Applying Seismic Attributes Technique at Misaada and Rabwa Fields, East Bahariya, Western Desert, Egypt

Adel A. A. Othman¹, Mohamed Fathy¹ and Mohamed Abdelraheim²

¹Geology Department, Faculty of science, Al-Azhar University, Egypt.

²Qarun Petroleum Company, Cairo, Egypt.

mohamed.abdelrhem12@gmail.com

Abstract: Most of the drilling activities in oil fields either in exploration or development phases are depending on structural interpretation of 3D seismic data y, which leads to good results in some areas and bad in others, so the demand to apply new methods, which were uncommon in the area of study, resulted in extracting more information from seismic data rather than using structural interpretation method. One of these methods is seismic attributes where we can extract information beyond the seismic reflectors that could lead to a better geological interpretation of the data, hence; seismic attributes have been used as interpretation tool for seismic Geomorphology in order to enhance imaging the subsurface structures, identify new prospects and reducing the development risk. It also can be used to indicate the presence or absence of hydrocarbons by predicting its effect on the amplitude away of the drilled wells.

[Adel A. A. Othman, Mohamed Fathy and Mohamed Abdelraheim. Subsurface Interpretation Applying Seismic Attributes Technique at Misaada and Rabwa Fields, East Bahariya, Western Desert, Egypt. Nat Sci 2018;16(3):71-78]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 7. doi:10.7537/marsnsj160318.07.

Keywords: Subsurface; Interpretation; Applying; Seismic Attribute; Technique; Misaada; Rabwa; Field;, East Bahariya; Western Desert; Egypt

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Capsular typing and Analysis of Virulence Genes of multidrug resistant Klebsiella Pneumoniae and Klebsiella oxytoca from hospital-associated specimen in Nigeria.

Thonda O. A¹ and Oluduro A. O²

¹Department of Biological Sciences, Microbiology Unit, Faculty of Science, Kings University, Ode-Omu, Osun State, Nigeria

²Department of Microbiology, Faculty of Science, Obafemi Awolowo University, Ile-Ife, Osun State

thondakemi22@gmail.com

Abstract: Klebsiella infections are caused mainly by Klebsiella pneumoniae and Klebsiella oxytoca. These isolates are important medical pathogen and responsible for some health problems especially nosocomial infections; pneumonia, septicaemia, respiratory tract and urinary tract infections. Capsule is an important virulence factor in K. pneumoniae. The aim of this study was to investigate the serotypes of K. pneumoniae and K. oxytoca and to detect the virulence genes. The clinical specimens were collected by standard methods from patients. The bacterial isolates were identified by conventional microbiological methods and the use of analytical profile index 20E (Bio-Mérieux, France) for the organisms. Molecular detection of the virulence genes was done by polymerase chain reaction and agarose gel electrophoresis. Capsule typing and virulence genes were characterized using PCR specific primers. PCR technique showed that thirteen (45%) isolates were positive for K1 gene, five (17%) for K2 gene and no isolates was amplified for K5 gene. The virulence MagA gene was present in 14 isolates, rmpA gene was detected in 10, rmpA1 gene was detected in 3 while wcaG gene was detected only in 1 isolates. The results suggest that there are K1 and K2 serotypes associated with magA, rmpA and wcaG genes of the K. pneumoniae in this region.

[Thonda O. A and Oluduro A. O. Capsular typing and Analysis of Virulence Genes of multidrug resistant Klebsiella Pneumoniae and Klebsiella oxytoca from hospital-associated specimen in Nigeria. Nat Sci 2018;16(3):79-85]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 8. doi:10.7537/marsnsj160318.08.

Keywords: Capsular serotyping, Virulence genes, K. pneumoniae, multidrug resistant, K. oxytoca

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Screening of germplasm against bacterial blight of cotton under field conditions

Muhammad Sheraz Rasheed¹, Muhammad Haroon¹, Zulqarnain Aslam¹, Asmat Ullah², Zafar Hussain^1**, Hina Firdous³, Muhammad Awais Ashraf¹

¹Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad, Pakistan.

²Institute of Soil and Environmental Sciences, University of Agriculture, Faisalabad, Pakistan.

³Department of Plant Pathology, University of Agriculture, Faisalabad, Pakistan.

**Corresponding author’s email: zafarhussainpbg@gmail.com

Abstract: The basic purpose of this study to evaluate the germplasm of cotton against bacterial blight of cotton under field conditions to search out resistant cultivar for the development of resistant variety. For this purpose, disease screening nursery of eleven cultivars was established in the experimental research of Department of Plant Pathology, University of Agriculture Faisalabad for two years 2016 and 2017. The seeds of eleven varieties were neither treated with chemical nor given acid delinting to increase chances of primary infection of the disease. Seeds of all varieties were sown under RCBD with three replications. No spreader was sown either around the field or between the lines. The varieties i.e. Bt-VH 329, Bt-MNH 886, and Bt-FH 177 expressed moderately resistant response with rating 4. Three varieties (Bt-FH 143, Bt-NS 131 and Non Bt-CM 82 exhibited moderately susceptible response with rating 5. Two varieties (Bt-FH 142, Bt-4243 and Bt-FH 169) showed susceptible response (rating 6) while Non Bt-Shahbaz and Non Bt- CRIS 134 expressed highly susceptible response with rating 7.

[Muhammad Sheraz Rasheed, Muhammad Haroon, Zulqarnain Aslam, Asmat Ullah, Zafar Hussain, Hina Firdous, Muhammad Awais Ashraf. Screening of germplasm against bacterial blight of cotton under field conditions. Nat Sci 2018;16(3):86-89]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 9. doi:10.7537/marsnsj160318.09.

Key words: Bacterial blight of cotton, germplasm, disease rating

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An approach for polishing drainage water using microcosm constructed wetland units

Ahmed A. Rashed and Hussein A.A El Gammal

National Water Research Center, P. O. Box 74, Cairo, Egypt
E-mail: Ahmedrashed2002@hotmail.com

Abstract: Egypt is among the most global countries which are facing severe escalating water shortage problems in the coming decades. The idea of using constructed wetlands for the treatment and improving of wastewater emerged in the second half of the last century. The main objectives of this study are; to compare the performance of floating treatment wetlands (FTW) with both plastic and gravel bed subsurface flow (SSF) CWs, to make a configuration of using shredded Polyethylene plastic water bottles as a SSF CW substrate, and to investigate the capabilities of using small scale low costs treatment wetlands in drainage water treatment as an unconventional irrigation water resource. To achieve these objectives, three microcosm constructed wetland cells made from one-m3 recycled plastic tanks were investigated in its early stage operation to treat agriculture drainage water as a low cost unconventional irrigation water source. Shredded Polyethylene Terephthalate (PETE) water bottles, natural gravel and foam floating reeds mats were used to produce 0.5 m3/day and 1.0 m3 /day of treated water. The three cells managed to treat the drainage water according to the Egyptian standards of discharging drainage water at fresh water courses. The results showed that the treatment efficiency of PETE bed cell obtained the best removal performance followed by the gravel bed cell then the floating bed except for ammonia where floating beds acted better than the others. The one-day treatment detention time batch flow operation had nearly twice the removal efficiency of the half-day batch flow. These microcosms may offer a low cost clean irrigation water source for small landowners. It is recommended to apply more investigations to examine the operation, maintenance and economic visibility of such microcosms in a long run scale.
[Ahmed A. Rashed and Hussein A.A El Gammal. An approach for polishing drainage water using microcosm constructed wetland units. Nat Sci 2018;16(3):90-97]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 10. doi:10.7537/marsnsj160318.10.

Keywords: Microcosm constructed wetland, Floating Treatment Wetland, Drainage Water, Lake Manzala, Shredded water bottles

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The Use of Microalgae in Bioremediation of the Textile Wastewater Effluent

Fekry M. Ghazal¹, EL-Sayed M. Mahdy², Mohamed S. Abd EL- Fattah², Abd ELGawad Y. EL-Sadany¹ and Naeem M. E. Doha¹

¹Agric. Res. Dept., Soils, Water & Environ. Res. Inst., Agric. Res. Center, Giza, Egypt

²Chemistry Dept., Fac. Sci., Helwan Univ., Cairo Egypt

ghazalfekry@gmail.com

Abstract: The run off of the textile dye effluents into Public water bodies is a major environmental and health problem. Color removal, in particular, recently becomes a substantial scientific interest, as revealed by the multitude of related research reports. During the past two decades, many physico-chemical decolorization techniques have been cleared, few, however, have been accepted by the textile industries. Their lack of implementation has been largely due to the high cost, low efficiency and ineffectively to a wide variety of dyes. The capacity of microorganisms to carry out dye decolorization has received much attention. Microalgae are considered as an important source for decolorizing the textile dye effluent. In the current work five local microalgae strains nameely Anabaena flos aquae, Nostoc elepsosporum, Nostoc linkia, Anabaena variabilis and Chlorella vulgaris, were y screened for their efficiency to grow on and the removal of the red color and the heavy metals, i.e., Chromium, lead, iron, copper, Molybdenum and arsenic from the textile wastewater effluent discharged by The textile factory located at the six October City, Industrial Region, Giza Governorate, Egypt. Results revealed that all tested microalgae strains were able to remove the color of the textile wastewater effluent after 4 weeks incubation periods under continuous illumination. Also, N. elepsosporum recorded the highest percentage of color removal percentage followed by C. vulgaris, A. Variabilis, N. linkia and A. flos aquae after 4 weeks of incubation. All the tested microalgae strains were able to remove Cr, Pb, Cu, Mo and As in different degrees. On the other respect, all tested microalgae strains raised pH and DO of the textile wastewater effluent, while they reduced EC, COD and BOD compared to the initial values of the initial values recorded by textile wastewater effluent. However, the more work should be done to confirm the ability of microalgae to be considered as a promising alternative of biological treatment to reduce the pollution load resulted from the textile wastewaters proposed to be drained into the public water bodies.

[Fekry M. Ghazal, EL-Sayed M. Mahdy, Mohamed S. Abd EL- Fattah, Abd ELGawad Y. EL-Sadany and Naeem M. E. Doha. The Use of Microalgae in Bioremediation of the Textile Wastewater Effluent. Nat Sci 2018;16(3):98-104]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 11. doi:10.7537/marsnsj160318.11.

Keywords: Anabaena flos aquae, Nostoc elepsosporum, Nostoc linkia, Anabaena variabilis and Chlorella vulgaris. - textile wastewater- physico-chemical properties, heavy metals and declorization.

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Efficacy of Colostrum or Coenzyme Q10 against some organ dysfunction induced by CCL₄ and EAC in mice

Gamal M. F. Edrees; Maher A. A. Amer, Mona S. Gouida and Mostafa I. A. Al-Tonbary.

Zoology Department, Faculty of Science, Mansoura University, Egypt.

mostafaaltonbary@gmail.com

Abstract: The role of Colostrum (50 mg/kg) or Coenzyme Q10 (100 mg/kg) on oxidative stress induced by Erlich ascites carcinoma [EAC] (0.02X10⁷ cells) and CCL₄ (1.5 ml / kg) in female mice were evaluated. Casepase 9 and Casepase 3 as well as Bax-1 were significantly decreased in EAC treated mice. In addition CD4, CD8, CD95 and Sub G1 significantly increased. These abnormalities are accompanied by increased the serum ALT, AST, T. bilirubin, Creatinine, Urea and uric acid and decline in Total protein and Albumin as well as disturbe mineral levels. Mice pretreated with Colostrum or Coenzyme Q10 then with EAC + CCL₄ showed marked protection against induced tumor substance.

[Gamal M. F. Edrees; Maher A. A. Amer, Mona S. Gouida and Mostafa I. A. Al-Tonbary. Efficacy of Colostrum or Coenzyme Q10 against some organ dysfunction induced by CCL₄ and EAC in mice. Nat Sci 2018;16(3):105-110]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub.net/nature. 12. doi:10.7537/marsnsj160318.12.

Key words: Colostrum, Coenzyme Q10, Ehrlich ascites carcinoma, CCL₄, Antioxidant.

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