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Cancer Biology Research Literatures

Dr. Mark Herbert

World Development Institute

39-06 Main Street, Flushing, Queens, New York 11354, USA, ma708090@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports as references in the related studies.

[Herbert M. Cancer Biology Research Literatures.Cancer Biology 2022;12(4):1-247]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  01.doi:10.7537/marscbj120422.01.

Key words: cancer; life; research; literature; cell

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Single Center Clinico-Epidemiological study of Female Patients with Breast Cancer

Sara Mohammed Abd Elkader Ayoub (MSC), Bahaa Said Ebrahim (MD), Nehal Mohamed ElMashad (MD), Alaa Mohamed Maria (MD),

Clinical Oncology & Nuclear Medicine Department, Faculty of Medicine, Tanta University, Egypt

Email: saraa.ayooub@gmail.com

Abstract: Aim of the Work: describe the clinico-epidemiological and pathological pattern of breast cancer (BC). Patients and Methods: This retrospective descriptive Hospital based epidemiological study for female patients with breast cancer presented at Clinical Oncology Department, Tanta University Hospitals throughout the period between January 2014 to 1^st of January 2019. Results: Female breast cancer represented 28.3% of patients presented during the period of study. The median age was 51 years. Supra-areolar position was present in 74% of patients and 5% had multicentric lesions. Stage II was the most prevalent (42.6%). Invasive ductal carcinoma was the most common pathological subtype and grade II was the most frequent. Intraductal component, lympho-vascular invasion (LVI) and perineural invasion (PNI) were missing in a large number of pathological reports. More than 60% were hormone receptor (HR) positive & HER2 was positive in 14.2%. expression of KI-67 was unknown in 42.5%. Surgery was done in the majority of patients with modified radical mastectomy (MRM) followed by conservative breast surgery (CBS) in 57.4% & 33.9% respectively. Chemotherapy was offered in most cases. Radiotherapy whether adjuvant or palliative was offered in most cases. Hormonal therapy was offered in almost all HR positive patients. Over 90% of cases were still alive by the end of the study. The median OS was 141 months, the median DFS was 66.5 months and the median PFS was 26 months. Conclusion: Breast cancer is a heterogenous disease that needs to be fully understood to tailor the best strategy to fight and overcome it. Screening programs are needed and defining risk categories will help in designing better screening methods for each category. Registry of cases will help to understand the disease burden in our region so that we become able to better define our problem and find the best solution.

[Sara Mohammed Abd Elkader Ayoub,Bahaa Said Ebrahim,Nehal Mohamed ElMashad, Alaa Mohamed Maria Single Center Clinico-Epidemiological study of Female Patients with Breast Cancer. Cancer Biology2022;12(4):248-256]. ISSN:2150-1041(print);ISSN:2150-105X(online). http://www.cancerbio.net 02.doi:10.7537/marscbj120422.02.

Keywords: Clinico-Epidemiological, female breast Cancer, screening, registry

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Evaluating clinicopathological profiling and treatment outcomes in Gastric cancer patients: a single institution experience

Karim Mashhour, MD, Menna Rady, MD, Mina Nashaat, Msc¹,  Emad Habib, MD

Kasralainy Center of Clinical Oncology and Nuclear Medicine, Cairo University, Cairo, Egypt

E-mail: karim.mashhour.81@gmail.com

Abstract: Background: Stomach cancer remains a major health problem in Egypt despite developments in diagnostic and therapeutic modalities with poor prognosis mainly due to its late-stage presentation, which is why it carries a burden on health and society. Aim of the study: to evaluate the incidence rate of gastric cancer among the patients treated at Kasr Al-Ainy Center of Clinical Oncology and Nuclear medicine (NEMROCK) as well as to correlate with patient’s demographic and clinico-pathological characteristics and treatment outcome. Patients and methods:  this is a retrospective study to evaluate the gastric cancer patients and their characteristics who received treatment at NEMROCK during the period from 2016 till 2020 and their data were extracted from the electronic database archive. Results: our series included 89 patients, Males and females have almost equal proportions among the included patients 50.6% versus 49.4% respectively where their median age was 54 years at the time of diagnosis, 56.2% of the included patients presented at an advanced stage with metastasis at their first presentation. Our study confirmed the impact of surgical resection on improving the survival where the median OS of patients who underwent surgical resection was 17.4 months Vs 8.4 months for those who didn’t have surgical resection, we also observed that neoadjuvant therapy used in the locally advanced disease cases improved the median OS to 16.7 months (p value 0.0009). Conclusion: Surgical resection, use of neoadjuvant chemotherapy and poor histo-pathologic features correlate with the treatment outcomes in gastric cancers treated at our institution.

[Karim Mashhour, Menna Rady, Mina Nashaat, Emad Habib. Evaluating clinicopathological profiling and treatment outcomes in Gastric cancer patients: a single institution experience. Cancer Biology 2022;12(4):257-266]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net  03.doi:10.7537/marscbj120422.03.

Keywords: Gastric cancer, Clinico-pathological features, Treatment, Risk factors

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