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A Medicinal Plant’s Extract
Effective on Tuberculosis in Cases of Neoplastic Transformation
in Tropical Nigeria
Adekunle Odunayo Adejuwon 1, 2, 3, 4, 5*, Victoria
Anatolyivna Tsygankova 6, Marina V. Donova 7,
Olaleke Odeleye 8
1
Department of Biological and Chemical Sciences, Faculty of
Natural and Applied Science, Atiba University, Oyo, Nigeria
2 Office of
the Dean, Faculty of Health Sciences, Atiba University, Oyo,
Nigeria
3
National Research
Foundation of Ukraine (NRFU), Maksymovych Scientific Library of
The Taras Shevchenko Kyiv National University Kyiv, Volodymyrska
Street 58, Office Number 38 Ukraine, East Europe,
4The
European Science Foundation College of Expert Reviewers (The
European Union (EU)); and The European Science Foundation
College of Review Panel Members (The European Union (EU)),
Offices: 1, Quai Lezay-Marnésia - BP 90015, 67008 Strasbourg
Cedex, France, Western Europe
5 Medwave
Company Limited, Istanbul, Istanbul Province, Republic of
Turkey, Southeastern Europe/Western Asia
6 Department for Chemistry of Bioactive Nitrogen-Containing
Heterocyclic Compounds, Institute of Bioorganic
Chemistry and Petrochemistry of the National Academy of Sciences of
Ukraine, 1, Murmanskaya Str., 02660,
Kyiv, Ukraine
7
G.K. Skryabin Institute of
Biochemistry and Physiology of Microorganisms of the Russian
Academy of Sciences,
Pushchino, 5, 142290,
Moscow, Russian Federation, East Europe
8
Department of Microbiology, Lead
City University, Ibadan, Nigeria
Corresponding
Author:
Professor Adekunle Odunayo Adejuwon, B.Sc., M.Sc., Ph.D.
(Microbiology – Microbial Physiology and Metabolism – Microbial
Enzymology), LL.Dip. (Diploma in Laws), Department of Biological
and Chemical Sciences, Faculty of Natural and Applied Sciences,
Atiba University, Oyo, Nigeria; and The Office of the Dean,
Faculty of Health Sciences, Atiba University, Oyo, Nigeria; And
Professor Adekunle Odunayo Adejuwon, B.Sc., M.Sc., Ph.D.
(Microbiology – Microbial Physiology and Metabolism – Microbial
Enzymology), LL.Dip. (Diploma in Laws) (Voluntary International
Referee – Professor of Microbiology), National Research
Foundation of Ukraine (NRFU), Maksymovych Scientific Library of
The Taras Shevchenko Kyiv National University Kyiv, Volodymyrska
Street 58, Office Number 38 Ukraine, East Europe; Professor
Adekunle Odunayo Adejuwon, B.Sc., M.Sc., Ph.D. (Microbiology –
Microbial Physiology and Metabolism – Microbial Enzymology),
LL.Dip. (Diploma in Laws),
The European Science Foundation
College of Expert Reviewers (The European Union (EU)); and
Professor Adekunle Odunayo Adejuwon, B.Sc., M.Sc., Ph.D.
(Microbiology – Microbial Physiology and Metabolism – Microbial
Enzymology), LL.Dip. (Diploma in Laws), The European
Science Foundation College of Review Panel Members (The European
Union (EU)), Offices: 1, Quai Lezay-Marnésia - BP 90015, 67008
Strasbourg, Cedex, France, Western Europe
e-mail address:
ao_adejuwon@yahoo.ca
ORCID Identifier:
https://orcid.org/0000-0001-9404-874X
Loop Profile:
1019729,
https://loop.frontiersin.org/people/1019729/overview
Publons:
https://publons.com/researcher/1487222/adekunle
Abstract: Background:
Infection with tuberculosis
is rampant in the tropics especially in crowded environments. It
is also a nosocomial disease that can be managed if detected
early. Investigation: 500g each of Ocimum gratissimum
L. leaves, bark of Psidium guajava L., bark of
Psychanthus angolensis (Welw) warb and leaves of Spondias
mombin L. were ground and added to 2L of 95% alcohol
(Sigma-Aldrich). The extract was left overnight for 24 hr. The
extract was filtered and concentrated to about one-sixth of its
original volume in vacuo using a rotary evaporator (Quick
fit, Rotavapor-R, Buchi, Switzerland) at 30oC under
low vacuum pressure and low evaporation. 50ml of the
concentrated extract was given orally to twenty human subjects
(n= 10 males; n=10 females) with neoplastic transformation
diagnosed with tuberculosis at the General Out-Patient clinic of
the University College Hospital, Ibadan, Nigeria. Oral
application of extract to subjects was immediately before meal
on a daily basis for a period of ten days. Observation:
All subjects tested negative for tuberculosis within a period of
fifteen days after end of therapy. Conclusion: The
concentrated alcohol extract was effective on tuberculosis.
[Adekunle
Odunayo Adejuwon , Victoria Anatolyivna Tsygankova, Marina V.
Donova, Olaleke Odeleye. A Medicinal Plant’s Extract
Effective on Tuberculosis in Cases of Neoplastic Transformation
in Tropical Nigeria 2021;11(2):106-108]. ISSN:2150-1041
(print); ISSN:2150-105X (online).
http://www.cancerbio.net.
3.
doi:10.7537/marscbj110221.03.
Keywords:
Ocimum gratissimum L.; Psidium guajava L.;
Psychanthus angolensis (Welw); Spondias mombin L.;
Leaves; Root bark; Alcohol extract; Tuberculosis; Neoplastic
transformation |
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