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Using of Mg Sulphate for Fetal Neuroprotection in women Presenting by Fetal Distress during labour at Term: A Randomized Controlled Trial.

Rehab Abdelhamid Aboshama and Laila Ezzat

Department of Obstetrics and Gynecology, Faculty of Medicine – Fayoum University, Fayoum, Egypt

E-mail: lailaezzat972000@gmail.com

Abstract MgSo4 protect the fetal from in-utero hypoxia by preventing large blood pressure fluctuations, increase cerebral blow flow and decrease pro-inflammatory cytokines. MgSO4 also blocks excess release of glutamate in the calcium channel, protecting the susceptible fetal and newborn brains from glutamate-induced damage and antioxidant effects. This study aims to determine the potential efficacy of MgSO4 as a neuroprotective agent for the term fetus given to women presented by intrapartum fetal distress. The study was done in Fayoum university Hospital from 2018 to 2019 and was approved by institute ethics committee. 200 single term pregnant women who develop intrapartum fetal distress according to Fayoum university hospital protocol participated in this study. The cases were randomly assigned to two groups (100 patients each). Results Risk of Apgar score less than 7 at 5 min was not significantly reduced in the MgSO4 group than that in placebo group. The number of NICU admission was 4 in MgSO4 group and 5 in placebo group and no cases show any neonatal complication. There is statistically significant difference between cases and controls as regards maternal outcomes and complications; with higher percentage of maternal complication were noted among cases who take MgSO4, but on the other hand there is no statistically significant difference regards type of maternal complications. In Conclusion Administration of MgSO4 was safe but did not offer significant cerebral protection from asphyxia in term fetus.

[Rehab Abdelhamid Aboshama and Laila Ezzat. Using of Mg Sulphate for Fetal Neuroprotection in women Presenting by Fetal Distress during labour at Term: A Randomized Controlled Trial. Cancer Biology 2020;10(4):1-6]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net. 1. doi:10.7537/marscbj100420.01.

Key Words Mgsulphate, fetal distress, labour, NICU, maternal complications

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Chlamydia Trachomatis and Waddlia Chondrophila among Women with Unexplained Early Miscarriage: Case-Control Study

Mohamed Sobhy Bakry M.D¹, Laila Ezzat M.D^1*, Eman E Mahmoud M.D², Sylvana N. Gaber M.D³, Almandouh H Bosilah M.D¹

¹Obstetrics and Gynecology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

²Clinical and Chemical Pathology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

³Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

msobhy7@yahoo.com, lailaezzat9720000@gmail.com^*, esm02@fayoum.edu.eg, drsylvy80@gmail.com, almandohhussen@yahoo.com

Abstract: Objective: To determine the prevalence of Chlamydia trachomatis and other infections of the genital tract and its relation to the incidence of early unexplained spontaneous miscarriages. Design: a case-control study. Setting: Fayoum University hospital. Patients: The study group included 300 women presenting with unexplained spontaneous miscarriage or missed abortion of gestational age 8-14 weeks. The control group included 300 women with normal pregnancy of the same gestational age. Intervention: All participants of both groups were subjected to 3 cervicovaginal swabs and placental sampling was added from the study group. One swab was used for a smear test of vaginal fluid pH evaluation and direct microscopy. The second swabs, cultured for aerobic bacteria and yeasts. The third swab of both groups and placental samples from the study group were cultured for aerobic and anaerobic bacteria and used for DNA extraction. The extracted DNA was subjected to a pan-Chlamydiales qPCR and positive samples were subjected to qPCR specific for Chlamydia trachomatis, Waddlia chondrophila and Parachlamydia acanthamoebae. Results: Candida infection and Trichomonas vaginalis represented the main infections in both groups without a statistically significant difference between both groups. Placental samples were positive in 20%, 21 cases were positive by culture and 39 cases by PCR. Pan- Chlamydiales were detected in 92 cervicovaginal samples of both groups and 39 placental samples of study group with a statistically significant difference between both groups (p <0.041). Chlamydia trachomatis qPCR was detected in cervicovaginal samples in 54 patients of the study group and 36 patients of control group, that was a statistically significant difference (p <0.04), and 31 placental samples of study group, representing 92.3% of all chlamydial infections. Waddlia chondrophila was detected in 2 cervicovaginal samples of both groups and 8 placental samples of the study group, representing 7.6% of all chlamydial infection, that was statistically insignificant difference between both groups (p=1). No Parachlamydia acanthamoebae detected in both groups. Conclusion: Chlamydia trachomatis and Waddlia chondrophila infections are possible factors for miscarriage as their prevalence was higher in cervicovaginal and placental samples of women with unexplained early miscarriage.

[Mohamed Sobhy Bakry, Laila Ezzat, Eman E Mahmoud, Sylvana N. Gaber, Almandouh H Bosilah. Chlamydia Trachomatis and Waddlia Chondrophila among Women with Unexplained Early Miscarriage: Case-Control Study. Cancer Biology 2020;10(4):7-16]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net. 2. doi:10.7537/marscbj100420.02.

Key Words: Miscarriage, Chlamydia trachomatis, Waddlia chondrophila, Parachlamydia acanthamoebae, placental samples.

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Cancer

Primarily from Wikipedia, the free encyclopedia

(https://en.wikipedia.org/wiki/Cancer)

Mark Herbert, PhD

World Development Institute

39 Main Street, Flushing, Queens, New York 11354, USA, ma708090@gmail.com

Abstract: Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements.^[1] While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans.

[Mark Herbert. Cancer. Cancer Biology 2020;10(4):17-42]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net. 3. doi:10.7537/marscbj100420.03.

Keywords: Cancer; disease; cell growth; benign tumor; symptom; humans

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Benign tumor

Primarily from Wikipedia, the free encyclopedia

(https://en.wikipedia.org/wiki/Benign_tumor)

Mark Herbert, PhD

World Development Institute

39 Main Street, Flushing, Queens, New York 11354, USA, ma708090@gmail.com

Abstract: A benign tumor is a mass of cells (tumor) that lacks the ability to either invade neighboring tissue or metastasize (spread throughout the body). When removed, benign tumors usually do not grow back, whereas malignant tumors sometimes do. Unlike most benign tumors elsewhere in the body, benign brain tumors can be life-threatening. Benign tumors generally have a slower growth rate than malignant tumors and the tumor cells are usually more differentiated (cells have more normal features). They are typically surrounded by an outer surface (fibrous sheath of connective tissue) or stay contained within the epithelium. Common examples of benign tumors include moles and uterine fibroids.

[Mark Herbert. Benign tumor. Cancer Biology 2020;10(4):43-47]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net. 4. doi:10.7537/marscbj100420.04.

Keywords: benign tumor； cell； metastasize； malignant tumors; growth rate; fibrous sheath; epithelium; uterine fibroid

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Cancer gene Research Literatures

Mark Herbert

World Development Institute

39-06 Main Street, Flushing, Queens, New York 11354, USA, ma708090@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports as references in the related studies.

[Mark Herbert. Cancer gene Research Literatures. Cancer Biology 2020;10(4):48-120]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net. 5. doi:10.7537/marscbj100420.05.

Key words: cancer; life; research; literature; cell; gene

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