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CONTENTS
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Titles /
Authors /Abstracts
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1
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Prognostic role of MiR-497-5p
as a molecular marker in papillary thyroid carcinoma in Saudi
patients
Rajab Alzahrani1, Wael
H. Elsawy2
Department of Surgery, Medical
College, Albaha University, SA.
Department of Clinical Oncology,
Faculty of medicine Zagazig University, Zagazig, Egypt.
drrajabg@gmail.com,
rasalzahrani@bu.com.sa
Abstract:
Thyroid cancer constitutes a
major health problem in Saudi females. We conducted this study
to evaluate the role of MiR-497-5p as a possible molecular
marker for prognosis and survival in Saudi patients. qRT-PCR was
used to assess MiR-497-5p expression in 36 Saudi patients with
papillary thyroid carcinoma (PTC) and in their nearby normal
tissues. Downregulation of MiR-497-5p was noted in all malignant
tumor tissues in relation to their corresponding normal tissues.
Downregulation was linked with poor prognostic features and
short overall and disease-free survival. MiR-497-5p function as
a tumor suppressor gene in PTC. The low levels of expression
were correlated with adverse prognostic clinical features and
short survival in Saudi patients with PTC. It may be used as a
possible molecular marker for prognosis and survival in PTC.
[Rajab
Alzahrani, Wael H. Elsawy. Prognostic role of MiR-497-5p as a
molecular marker in papillary thyroid carcinoma in Saudi
patients.
Cancer Biology
2020;10(2):1-5].
ISSN:
2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
1.
doi:10.7537/marscbj100220.01.
Keywords:
Papillary thyroid cancer,
MiR-497-5p, Tissues, Prognosis |
Full Text |
1
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2
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Evaluation of the Prognostic
Role of Androgen Receptors in Non-Metastatic Invasive
Triple-Negative Breast Cancer Patients: A Clinicopathologic and
Immunohistochemical Study
Asmaa Raafat 1, Hanan
Shawky 1, Mohamed Shareef 2, and Mohamed
Sheta1
1
Department of Oncology, 2 Department of Pathology,
Faculty of Medicine, Tanta University, Egypt
Abstract:
Background:
Breast cancer is the second most common cause of death from
cancer in females. Continuous research is therefore mandatory
for new prognostic markers that will assist in therapy. The aim
of this work is to study androgen receptor expression (AR) in
non-metastatic TNBCs and to correlate these data with
clinicopathologic findings and patient disease -free survival (DFS)
and overall survival (OS) to assess its prognostic significance.
Patients & Methods: Paraffin blocks were analyzed for AR
immunohistochemical expression, obtained from 100 female
patients with non-metastatic invasive TNBCs. All patients
treated at the Department of Clinical Oncology, Faculty of
Medicine, Tanta University Hospital during the period from
January 2011 to December 2017. The date of this analysis was
January 2020. Results: Androgen receptors showed positivity in
33 cases (33%). There was a statistical significant correlation
between AR positivity and tumor grade (p= < 0.001), tumor size
(p= < 0.001), Ki 67 (P=< 0.001), lympho-vascular invasion (p=<
0.001), and menopausal status (P= 0.012). However, there was no
statistical significant difference when looking at the
correlation between AR positivity and ECOG PS (p= 0.728), family
history (p=0.902), pathological subtypes (p= 0.071), nodal
status (p= 0.222), and age (p= 0. 437). Two year and 5- year DFS
in AR +ve patients were 87.88% and 59.66 % respectively. While
in AR – ve patients the 2 -year and 5- year DFS were 25.37% and
13.43% respectively with statistically significant difference (P
< 0.001). The 2-year OS was 93.94 % versus 61.19 % for AR +ve
and AR –ve tumors respectively. While the 5-year OS was 84.85%
versus 16.53% for AR positive and AR-negative tumors
respectively with statistically significant difference (P
<0.001). Conclusion: In TNBC patients it could provide
prognostic information by adding AR to the marker panel used in
current clinical practice. In patients with non-metastatic
invasive TNBCs, AR seems to be a potentially useful marker for
good prognosis.
[Asmaa
Raafat, Hanan Shawky, Mohamed Shareef, and Mohamed Sheta.
Evaluation of the Prognostic Role of Androgen Receptors in
Non-Metastatic Invasive Triple-Negative Breast Cancer Patients:
A Clinicopathologic and Immunohistochemical Study.
Cancer Biology
2020;10(2):6-13].
ISSN:
2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
2.
doi:10.7537/marscbj100220.02.
Key words:
androgen receptors,
Triple-negative breast cancer, Clinicopathologic study,
Immunohistochemical Study. |
Full Text |
2
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3
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The Efficacy Of Methanol,
Dichloromethane And N-Butanol Extracts Of Anonna Muricata
Leaves On Selected Bacteria And Fungi
1akintelu
Sunday Adewale And 2*Folorunso Aderonke Similoluwa
1Department
of Pure and Applied Chemistry, Ladoke Akintola University of
Technology, PMB 4000 Ogbomoso, Nigeria.
2Department
of
Chemistry, Louisiana State University,
Louisiana,
USA
*Email:
folorunsoaderonkesimi@gmail.com
Phone number +2348136872649
Abstract:
In Nigeria, Annona muricata
is locally being use as source of medicine for curing
various infections. This research was aimed at determination of
the potency of the leaves against selected bacterial and fungal
strains. The antibacterial and antifungal activities of
methanol, dichloromethane and n-butanol extracts of Annona
muricata leaves against selected bacterial and fungi strains
were examined. Methanol, dichloromethane and n-butanol extracts
of Annona muricata leaves showed high inhibitory activities
between (24-29 mm) against Bacillus subtilis, (25-29mm) against
Clostridium sporogenes, (25-29) against Entrococcus faecalis
(30-31) against Klebsiella pneumonia, (26-31) against and
(26-30) against Staphyloccus aureus. The antifungal activities
of methanol, dichloromethane and n-butanol extracts of Annona
muricata leaves showed broad inhibition zones against the growth
of Aspergillus flavus, Candida albican, Fusarium oxysperium and
Penicillium camemeri. These study provide scientific information
and justification that support the local use Annona muricata
leaves as medicinal therapy and equally revealed Annona
muricata leaves as a major ingredient to bank on for the
design of novel antibiotics.
[Akintelu
Sunday Adewale And Folorunso Aderonke Similoluwa. The
Efficacy Of Methanol, Dichloromethane And N-Butanol Extracts Of
Anonna Muricata Leaves On Selected Bacteria And Fungi.
Cancer Biology
2020;10(2):14-17].
ISSN:
2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
3. doi:10.7537/marscbj100220.03.
Keywords:
Antifungal, antibacterial,
efficacy and annonamuricata |
Full Text |
3
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4
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Application of
Image Processing for Detection and Classification of Malignant
and Benign Breast Cancer Tissues
Hala Moustafa
1, Metwally Kotb2, Heba Ramadan 2,
Diana El-Sherif 3
1Medical
Biophysics and Biomedical Equipment's, Faculty of Applied
Medical Sciences, October 6 University.2Medical
Biophysics, Medical Research Institute, University of
Alexandria.
3
Radiology Department, Faculty of Applied Medical Sciences.
Abstract:
Objective:
To compare between images obtained by two modalities employing
two software programs as a trial to obtain solid conclusion of
using either of these modalities for the better differentiation
between benign and malignant breast tumors. Methods: A
total of 60 female breast patients were enrolled, in addition to
10 control female with no symptoms of breast disease. The
patients were divided into two main groups; one group of benign
and the other of malignant breast changes. All groups were
submitted to mammography and ultrasound breast examination. In
mammography, two routine views; a top-to-bottom CC view and an
oblique side MLO view were recorded. Photo Shop 7.0 ME Software
and MATLAB Software were employed, based on the gray-level
histogram, to describe the obtained data. Results: Gray
level histogram in benign breast tissue appears as a broad peak
at the middle with sharp top and more area, in mammography, as a
peak with broad base and sharp top, shifted and skewed (-) to
left, in ultrasonography. Malignant tissue, appears as: a broad
peak at the middle, with broad base and broad top, in
mammography, as a peak with sharp top extends from the middle,
shifted and skewed (-) to left, in ultrasonography, and as a
peak of gradual increase in intensity forming sharp peak at the
lower end of the histogram. The sensitivity increases on the
expense of specificity, and vice versa.
[Hala
Moustafa, Metwally Kotb, Heba Ramadan, Diana El-Sherif.
Application of Image Processing for Detection and Classification
of Malignant and Benign Breast Cancer Tissues. Cancer Biology 2020;10(2):18-28].
ISSN: 2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
4.
doi:10.7537/marscbj100220.04.
Keywords:
Images Processing -Benign Breast Cancer -Malignant Breast Cancer
- Photo Shop 7.0 ME Software -MATLAB Software – Mammography-
Ultrasonography |
Full Text |
4
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5
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Cancer Gene List - II
Mark Herbert
World Development Institute
39-06 Main Street, Flushing,
Queens, New York 11354, USA,
ma708090@gmail.com
Abstract: There
are thousands of genes that are related to the cancer
development. This article gives the genes that are supposed as
cancer genes. This is cancer gene list part 2.
[Herbert
M. Cancer Gene
List - II. Cancer
Biology 2020;10(2):29-35].
ISSN: 2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
5. doi:10.7537/marscbj100220.05.
Key words:
cancer; gene; DNA; life; medicine |
Full Text |
5
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6
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Cancer Gene List - III
Mark Herbert
World Development Institute
39-06 Main Street, Flushing,
Queens, New York 11354, USA,
ma708090@gmail.com
Abstract:
There are
thousands of genes that are related to the cancer development.
This asreticle gives 1400 genes that are supposed as cancer
genes. This is cancer gene list part 3.
[Herbert
M. Cancer
Gene List - III. Cancer Biology 2020;10(2):36-58].
ISSN: 2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
6. doi:10.7537/marscbj100220.06.
Key words:
cancer; gene; DNA; life; medicine |
Full Text |
6
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7
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Cancer Gene List - IV
Mark Herbert
World Development Institute
39-06 Main Street, Flushing,
Queens, New York 11354, USA,
ma708090@gmail.com
Abstract:
There are
thousands of genes that are related to the cancer development.
This asreticle gives 1400 genes that are supposed as cancer
genes. This is cancer gene list part 4.
[Herbert
M. Cancer Gene List - IV. Cancer Biology
2020;10(2):59-77].
ISSN:
2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
7. doi:10.7537/marscbj100220.07.
Key words:
cancer; gene; DNA; life; medicine |
Full Text |
7
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8
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Cancer Gene List - V
Mark Herbert
World Development Institute
39-06 Main Street, Flushing,
Queens, New York 11354, USA,
ma708090@gmail.com
Abstract:
There are
thousands of genes that are related to the cancer development.
This asreticle gives 1400 genes that are supposed as cancer
genes. This is cancer gene list part 5.
[Herbert
M. Cancer Gene
List - V. Cancer
Biology 2020;10(2):78-103].
ISSN: 2150-1041 (print); ISSN: 2150-105X (online).
http://www.cancerbio.net.
8. doi:10.7537/marscbj100220.08.
Key words:
cancer; gene; DNA; life; medicine |
Full Text |
8
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The manuscripts in this
issue were presented as online first for peer-review starting
from
April 23, 2020.
All comments are
welcome:
editor@sciencepub.net
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