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Antitumor effects of osmium (II) and ruthenium (II) bipyridine complexes containing the acetylacetonato ligand against the growth of Eherlich Ascites Cell Carcinoma

El-Shahat A. Toson

Chemistry Department (Biochemistry Division), Faculty of Science (Damietta), Mansoura University, Egypt.

Abstract: The development of metal-based antitumor drugs has been stimulated by the clinical success of cisplatin and its analogs and by the clinical trials of other platinum and ruthenium complexes with activity against resistant tumors and with reduced toxicity of normal cells. In the present study, the newly synthesized [OsII(bpy)₂(acac)](PF6) and [RuII(bpy)₂(acac)](PF6) complexes were tested for their cytotoxicities against Eherlich Ascites Cells (EAC) carcinoma, for their superoxide dismutase (SOD)- like activities and for their cytoprotective effects of the normal human red blood cells (RBCs) against photo-irradiation induced by UV-lamb in the presence of m-chloroperbenzoic acid, in vitro. Also, their killing capabilities for the growth of EAC carcinoma in vivo and the measurements of the biochemical changes accompanying such killing were investigated. The in vitro study revealed that the average cytoprotective effects of RBCs, SOD- like activities and the cytotoxicity of EAC by similar concentrations of rutheniumII (RuII) and osmium (OsII) complexes were 91.5% and 98.3%, 89.9% and 89.8% and 90% and 92.8%, respectively. In the in vivo study, the mean SOD activities in both RBCs and liver of the tumorized mice were statistically significantly inhibited compared with those of the control group (P<0.0001). After treatment either with RuII and OsII complexes, the activities of the latter enzyme in RBCs and liver were elevated (P<0.0007, P<0.04 and P<0.09 and P >0.05, respectively). Also, the mean activity of catalase was inhibited in liver tissues in the tumorized animals and re-elevated after complexes treatment. In addition, treatment with these complexes elevate the glutathione (GSH) levels in liver tissues of the tumorized and normal mice with simultaneous reduction in the mean levels of the corresponding values of malondialdehyde. On the other side, the mean levels of triglycerides and cholesterol were reduced in liver tissues but the mean levels of total lipids and total proteins were elevated after treatment. Moreover, the mean levels of DNA and RNA were significantly elevated in liver tissues of the tumorized animals and significantly reduced after treatment of the tumorized mice with the complexes. The previous results reflect tumor growth inhibition and prevention of EAC carcinoma metastasis into the liver. In conclusion, RuII and OsII bipyridine complexes are promising free radical scavengers in phototherapy and may be used as anti-tumor and anti-metastatic agents in the clinical trials in the future.

[El-Shahat A. Toson. Antitumor effects of osmium (II) and ruthenium (II) bipyridine complexes containing the acetylacetonato ligand against the growth of Eherlich Ascites Cell Carcinoma. Cancer Biology 2011;1(4):1-12]. (ISSN: 2150-1041). http://www.cancerbio.net. 1

doi:10.7537/marscbj010411.01

Key words: Photo-irradiation, complexes, cytotoxicity, tumors, malondialdehyde and metastasis

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STUDIES ON TICKS OF CATTLE AND THEIR BACTERIAL ISOLATES

¹ZARIA, L.T., ²BIU A.A. ³RABO, J.S., ⁴Dawurung J.S and ⁵ESTER, N.M.

^1,2&5Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria

³Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Agriculture, Makurdi, Nigeria

⁴WHO National Polio Laboratory, University of Maiduguri teaching Hospital, Maiduguri, Nigeria

dawurungj@yahoo.com

ABSTRACT:Entomological and bacteriological Studies on tick species infesting cattle was conducted in this investigation.A total of 504 ticks were found to infest the 50 cattle examined indicating a burden of 144 [28%.6%], 121 [24.0%], 117 [23.2%] and 122 [24.2%] for Boophilus, Rhipicephalus, Hyalomma and Amblyomma species respectively. Bacteriological examination revealed that 302 [59.9%] ticks were positive for bacterial growth viz; Boophilus 130 [90.3%], Rhipicephalus 101 [84.2%], Hyalomma 46 [39.3%] and Amblyomma 25 [20.5%]. Colony count [CC] from Boophilus was 58 [50.0%] for Staph. aureus and 29 [25.0%] each for Proteus and Corynebacterium.Rhipicephalus harboured 24 [33.3%] Staph. aureus and 48 [66.7%] Corynebacterium, Amblyomma harboured only 48 [100%] Corynebacterium, while Hyalomma had 47 [66.2%] Staph. aureus and 24 [33.8%] Corynebacterium species. The disk diffusion sensitivity method revealed that both gram positive isolates were susceptible to CIP, GN, CO and OF and the gram negative Proteus to CIP only.

[ZARIA, L.T., BIU A.A. RABO, J.S., Dawurung J.S and ESTER, N.M. STUDIES ON TICKS OF CATTLE AND THEIR BACTERIAL ISOLATES. Cancer Biology 2011;1(4):13-15]. (ISSN: 2150-1041). http://www.cancerbio.net. 2

doi:10.7537/marscbj010411.02

Keyword: TICKS, CATTLE, BACTERIAL ,ISOLATES

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Cancer and Carcinogens Research Literatures

Mark H Smith

Queens, New York 11418, USA

mark20082009@gmail.com

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This paper is the collections of literatures on carcinogen research.

[Smith MH. Cancer and Carcinogens Research Literatures. Cancer Biology 2011;1(4):16-36]. (ISSN: 2150-1041). http://www.cancerbio.net. 3

doi:10.7537/marscbj010411.03

Keywords: cancer; biology; research; life; disease; carcinogen

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Cancer and Pathology

Mark H Smith

Queens, New York 11418, USA

mark20082009@gmail.com

Abstract: This is the literature collections on cancer and pathology reserches.

[Smith MH. Cancer and Pathology. Cancer Biology 2011;1(4):37-94]. (ISSN: 2150-1041). http://www.cancerbio.net. 4

doi:10.7537/marscbj010411.04

Keywords: cancer; biology; research; life; disease; pathology

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Cancer and Oncogenes Literatures

Mark H Smith

Queens, New York 11418, USA

mark20082009@gmail.com

Abstract: This is a literature collection on cancer and oncogenes.

[Smith MH. Cancer and Oncogenes Literatures. Cancer Biology 2011;1(4):95-136]. (ISSN: 2150-1041). http://www.cancerbio.net. 5

doi:10.7537/marscbj010411.05

Keywords: cancer; biology; research; life; disease; oncogene

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Cancer Type literatures

Mark H Smith

Queens, New York 11418, USA

marksmithusa12@gmail.com

Abstract: This is a literature collection on cancer types.

[Smith MH. Cancer Type literatures. Cancer Biology 2011;1(4):137-172]. (ISSN: 2150-1041). http://www.cancerbio.net. 6

doi:10.7537/marscbj010411.06

Keywords: cancer; biology; research; life; disease

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Cancer Surgery

Mark H Smith

Queens, New York 11418, USA

mark20082009@gmail.com

Abstract: This is a literature collection on cancer surgery.

[Smith MH. Cancer Surgery. Cancer Biology 2011;1(4):173-278]. (ISSN: 2150-1041). http://www.cancerbio.net. 7

doi:10.7537/marscbj010411.07

Keywords: cancer; biology; research; life; disease; surgery

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Cancer and Radiation Literatures

Mark H Smith

Queens, New York 11418, USA

mark20082009@gmail.com

Abstract: This is literature collection on cancer and radiation.

[Smith MH. Cancer and Radiation. Cancer Biology 2011;1(4):279-334]. (ISSN: 2150-1041). http://www.cancerbio.net. 8

doi:10.7537/marscbj010411.08

Keywords: cancer; biology; research; life; disease; radiation

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