Heart Diseases in the United States

 

Ma Hongbao, Ph.D.,

Department of Medicine, Michigan State University, East Lansing, MI 48824, USA

 

The data in this article are from American Heart Association (2002 Heart and Stroke Statistical Update, American Heart Association, Dallas, Texas).

 

In 1940 there were 132 million Americans. By 1999 the population had more than doubled to about 273 million. In 1940 the proportion of Americans over age 65 was only 6.8%. By 1999 it had increased to 12.7%. Since 1940 the number of deaths from cardiovascular diseases has increased, partly because the elderly population has increased as a percentage of the total U.S. population. The average life expectancy of people born in the United States is now 76.7 years. Many factors may affect the decline in cardiovascular disease (CVD) mortality. They include more effective medical treatment, more emphasis on reducing the major controllable cardiovascular risk factors (high blood pressure, smoking, high blood cholesterol, physical inactivity, overweight and obesity, and diabetes), and better treatment for heart attack and stroke patients. There were 529,659 deaths from coronary heart disease (CHD) in 1999 and 459,841 in 1998.

 

Diseases of the Heart

• Acute Rheumatic Fever/Chronic Rheumatic Heart Diseases

• Hypertensive Heart Disease and Hypertensive Heart and Renal Disease

• Coronary Heart Disease

• Pulmonary Heart Disease and Diseases of Pulmonary Circulation

• Congestive Heart Failure

• Other Forms of Heart Disease

 

ABOUT SUDDEN Death and Cardiac Arrest

Most known heart diseases can lead to cardiac arrest and sudden death. The most common underlying cause is coronary heart disease, which includes heart attack. In 90% of adult victims of sudden death, two or more major coronary arteries are narrowed by atherosclerosis. Scarring from a prior heart attack is found in two-thirds of victims.

 

When sudden death occurs in young adults, other heart abnormalities are more likely causes. Under certain conditions, various heart medications and other drugs — as well as illegal drug abuse — can lead to abnormal heart rhythms that cause cardiac arrest and sudden death. Other causes of cardiac arrest include respiratory arrest, electrocution, drowning, choking and trauma. Cardiac arrest also can occur without any known cause.

 

About 250,000 people a year die of coronary heart disease without being hospitalized in US. That’s about half of all deaths from CHD — more than 680 Americans each day. If cardiac arrest victims receive no treatment, brain damage can start to occur in just 4 to 6 minutes after the heart stops pumping blood. If cardiac arrest victims receive immediate cardiopulmonary resuscitation (CPR), it will keep blood flowing to the heart and brain until definitive treatment is provided. CPR consists of mouth-to-mouth rescue breathing and chest compressions. VF cardiac arrest can be reversed if the victim is treated with an electric shock to the heart within a few minutes. The electric shock can stop the abnormal rhythm and allow a normal rhythm to resume. This process, called defibrillation, is done using a defibrillator. Lay rescuers can be trained to operate portable, computerized, automated external defibrillators (AEDs).

 

A victim’s chances of survival after VF cardiac arrest are reduced by 7 to 10% with every minute that passes without treatment. Few resuscitation attempts succeed after 10 minutes have elapsed. It’s estimated that more than 95% of cardiac arrest victims die before reaching the hospital. Early CPR and rapid defibrillation combined with early advanced care can produce high long-term survival rates for witnessed cardiac arrest.

 

CARDIOVASCULAR Diseases

Prevalence

61,800,000 Americans have one or more types of cardiovascular disease (CVD). Of these, 29,700,000 are male and 32,100,000 are female. 24,750,000 are estimated to be age 65 and older.

• High blood pressure — 50,000,000.

• Coronary heart disease — 12,600,000.

— Myocardial infarction — 7,500,000.

— Angina pectoris — 6,400,000.

• Stroke — 4,600,000.

• Congenital cardiovascular defects — 1,000,000.

• Congestive heart failure — 4,790,000.

• 1 in 5 males and females has some form of cardiovascular disease.

 

Mortality

CVD claimed 958,775 lives in the United States in 1999. This is 40.1% of all deaths or 1 of every 2.5 deaths. CVD was about 60% of “total mention mortality,” which means that of the more than 2,000,000 deaths from all causes, CVD was listed as a primary or contributing cause on about 1,391,000 death certificates.

• Since 1900, CVD has been the No. 1 killer in the United States every year but 1918.

• More than 2,600 Americans die of CVD each day, an average of 1 death every 33 seconds.

• CVD claims almost as many lives each year as the next 7 leading causes of death combined.

• Almost 150,000 Americans killed by CVD each year are under age 65.

• 1999 CVD mortality: male deaths — 445,871 (46.5% of deaths from CVD); female deaths — 512,904 (53.5% of deaths from CVD) (Note: Includes congenital cardiovascular disease).

• In 1999, 33% of deaths from CVD occurred prematurely (i.e., before age 75, the approximate average life expectancy in that year).

• The 1999 overall death rate from CVD was 354.1. The rates were 411.5 for white males and 526.0 for black males; 295.0 for white females and 402.1 for black females.

• From 1989 to 1999 death rates from CVD declined 15.6%. In the same 10-year period actual CVD deaths increased 2.1%.

 

Comparisons

• Other causes of death in 1999 — cancer 549,838; accidents 97,860; Alzheimers disease 44,536; HIV (AIDS) 14,802.

• According to the most recent CDC/NCHS computations, if all forms of major CVD were eliminated, life expectancy would rise by almost 7 years. If all forms of cancer were eliminated, the gain would be 3 years. According to the same study, the probability at birth of eventually dying from major CV diseases is 47%, and the chance of dying from cancer is 22%. Additional probabilities are 3% for accidents, 2% for diabetes and 0.7% for HIV.

• In the United States in 1999, CVD claimed the lives of 445,871 males and 512,904 females, while cancer killed 285,832 males and 264,006 females. The CVD death rates were 418.2 for males and 303.2 for females; cancer death rates were 251.6 for males and 169.9 for females.

• Breast cancer claims the lives of 41,144 females each year; lung cancer claims 62,703. The 1999 death rates were 27.0 for breast cancer and 40.8 for lung cancer.

 

Age, Sex, Race and Ethnicity

— The average annual rates of first major cardiovascular events rise from 7 per 1000 men at ages 35-44 to 68 per 1000 at ages 85-94. For women, comparable rates are achieved 10 years later in life. The gap closes with advancing age.

— Under age 75, there is a higher proportion of CVD events due to coronary heart disease (CHD) in men than in women, and a higher proportion due to congestive heart failure (CHF) in women than in men.

• The age-adjusted prevalence of CVD in adults for non- Hispanic whites is 30.0% for men and 23.8 for women; for non-Hispanic blacks it’s 40.5% for men and 39.6 for women; and for Mexican Americans it’s 28.8% for men and 26.6 for women.

• There are higher CVD risk factors among black and Mexican-American women than among white women of comparable socioeconomic status (SES). The large differences by both ethnicity and SES underscore the critical need to improve screening, early detection and treatment of CVD-related conditions for black and Mexican-

• Among American Indians/Alaska Natives age 18 and older, 63.7% of men and 61.4% of women have one or more CVD risk factors (hypertension, current cigarette smoking, high blood cholesterol, obesity or diabetes). If data on physical activity had been included in this analysis, the prevalence of risk factors probably would have been higher.

• Surveys show that most women are far more afraid of breast cancer than of cardiovascular disease (even though 1 in 30 women’s deaths is from breast cancer while 1 in 2.4 is from CVD).

 

Aftermath

• From 1979 to 1999 the number of Americans discharged from short-stay hospitals with CVD as the first listed diagnosis increased 29%.

• In 1999 CVD ranked highest among all disease categories in numbers of hospital discharges. That year CVD was the first listed diagnosis of 6,344,000 inpatients (3,161,000 males and 3,183,000 females).

• In 1999 there were 59,965,000 physician office visits and 5,862,000 outpatient department visits with a primary diagnosis of CVD.

• In 1998, $26.4 billion in payments were made to Medicare beneficiaries for hospital expenses due to cardiovascular problems. That was an average of $7,937 per discharge.

• In 1997, 25.8% of elderly nursing home residents age 65 and older had a primary diagnosis of cardiovascular disease at admission. This was the highest disease category for these residents. (1997 National Nursing Home Survey, USDHHS, April 25, 2000)

• In 1999 the annual rate of emergency department visits for cardiovascular conditions was 16.2 per 1,000 persons, up from 15.4 in 1992.

 

CORONARY Heart Disease and Angina Pectoris

 

Coronary Heart Disease

Coronary heart disease (CHD) caused 529,659 deaths in the United States in 1999 — about 1 of every 5 deaths. CHD total mention mortality — 680,000 of the more than 2,000,000 deaths from all causes.

• CHD is the single largest killer of American males and females.

• About every 29 seconds an American will suffer a coronary event, and about every minute someone will die from one.

• This year an estimated 1,100,000 Americans will have a new or recurrent coronary attack (defined as myocardial infarction or fatal CHD). About 650,000 of these will be first attacks and 450,000 will be recurrent attacks.* Over 45% of the people who experience a coronary attack in a given year will die from it.

• About 250,000 people a year die of CHD without being hospitalized. Most of these are sudden deaths caused by cardiac arrest, usually resulting from ventricular fibrillation.

• Yearly totals of sudden cardiac death in people ages 15 to 34 rose from 2,719 in 1989 to 3,000 in 1996. Alarmingly, though the numbers are very small, the death rate increased by 30% in young women. Death rates were also higher among young African Americans than among Caucasians.

• 12,600,000 people alive today have a history of heart attack, angina pectoris (chest pain) or both. This is about 6,200,000 males and 6,400,000 females.

• It’s estimated that 7,500,000 Americans age 20 and older have a history of myocardial infarction (about 4,600,000 men and 2,900,000 women).

• From 1989 to 1999, the death rate from CHD declined 24.0%, but the actual number of deaths declined only 6.8%.

 

Age, Sex, Race and Ethnicity

• 85% of people who die of CHD are age 65 or older.

• The average age of a person having a first heart attack is 65.8 for men and 70.4 for women.

• About 80% of CHD mortality in people under age 65 occurs during the first attack.

• Based on data from the NHLBI’s Framingham Heart Study in its 44-year follow-up of participants and the 20-year follow-up of their offspring...

— CHD is the predominant cardiovascular event, comprising more than one-half of all such events in men and women under age 75.

— The lifetime risk of developing CHD after age 40 is 49% for men and 32% for women.

— The incidence of CHD in women lags behind men by 10 years for total CHD and by 20 years for more serious clinical events such as MI and sudden death.

— CHD rates in women after menopause are 2-3 times those of women the same age before menopause.

• 50% of men and 63% of women who died suddenly of CHD had no previous symptoms of this disease.

• 1999 CHD mortality: male deaths — 267,268 (50.5% of deaths from CHD); female deaths — 262,391 (49.5% of deaths from CHD).

• In 1999 the overall CHD death rate was 195.6. The death rates were 249.4 for white males and 272.6 for black males, and 152.5 for white females and 192.5 for black females.

• 1999 preliminary death rates for CHD were 138.4 for Hispanics, 123.9 for American Indians/Alaska Natives and 115.7 for Asian/Pacific Islanders (CDC/NCHS).

• Among Americans age 20 and older, the age-adjusted prevalence of CHD for non-Hispanic whites is 6.9% for men and 5.4 for women; for non-Hispanic blacks it’s 7.1% for men and 9.0 for women; and for Mexican Americans it’s 7.2% for men and 6.8 for women.

• Among Americans age 20 and older, the age-adjusted prevalence of MI for non-Hispanic whites is 5.2% for men and 2.0 for women; for non-Hispanic blacks it’s

4.3% for men and 3.3 for women; and for Mexican Americans it’s 4.1% for men and 1.9 for women.

• The annual rates per 1,000 population of new and recurrent heart attacks in non-black men are 26.3 for ages 65-74, 39.7 for ages 75-84, and 53.6 for age 85 and older. For non-black women in the same age groups the rates are 7.8, 21.0 and 24.2, respectively. For black men the rates are 16.3, 54.9 and 40.8, and for black women the rates are 13.3, 18.3 and 14.1, respectively.

• Among American Indians ages 65-74, the annual rates (per 1,000) of incident heart attacks are 6.8 for men and 2.2 for women. (Strong Heart Study [1991-98], NHLBI)

• The average annual CHD incidence rate (per 1,000) in middle-aged Japanese-American men living in Hawaii was 4.6 for ages 45-49, 6.0 for ages 50-54, 7.2 for ages 55-59, 8.8 for ages 60-64, and 10.5 for ages 65-68.

— During the 19-year follow-up of this study (1966-84), the age-adjusted annual CHD mortality rate (per 1,000) decreased from 4.7 to 2.9, with an estimated annual decline of 2.7%. This trend is similar to that reported for U.S. white males of comparable ages in the same period.

 

Aftermath

• 25% of men and 38% of women will die within 1 year after having an initial recognized MI.

• In part because women have heart attacks at older ages than men do, they’re more likely to die from them within a few weeks.

• People who’ve had a heart attack have a sudden death rate that’s 4-6 times that of the general population.

• CHD is a prominent cause of death in adults at the peak of their productive lives.

• Depending on their sex and clinical outcome, people who survive the acute stage of a heart attack have a chance of illness and death that’s 1.5-15 times higher than that of the general population. The risk of another heart attack, sudden death, angina pectoris, heart failure and stroke — for both men and women — is substantial.

• Within 6 years after a recognized heart attack…

— 18% of men and 35% of women will have another heart attack.

— 7% of men and 6% of women will experience sudden death.

— About 22% of men and 46% of women will be disabled with heart failure.

• Almost half of men and women under age 65 who have a heart attack (MI) die within 8 years.

• About two-thirds of heart attack patients don’t make a complete recovery, but 88% of those under age 65 are able to return to their usual work. The outlook for people who have an unrecognized attack is about the same or worse.

• 1,317,000 males and 945,000 females diagnosed with CHD were discharged from hospitals in 1999. From 1979 to 1999, these discharges increased 29.9% for men and 30.5% for women.

• CHD is the leading cause of premature, permanent disability in the U.S. labor force, accounting for 19% of disability allowances by the Social Security Administration.

• In 1998, $10.6 billion was paid to Medicare beneficiaries for CHD ($10,428 per discharge for acute MI; $11,399 per discharge for coronary atherosclerosis and $3,617 per discharge for other CHD).

 

Angina Pectoris

About 6,400,000 Americans have angina pectoris (chest pain or discomfort due to insufficient blood flow to the heart muscle) — about 2,400,000 males and 4,000,000 females. Asmall number of deaths due to coronary heart disease are coded as being from angina pectoris. These are included as a portion of total deaths from CHD.

• About 400,000 new cases of stable angina (predictable chest pain on exertion or under mental or emotional stress) and about 150,000 new cases of unstable angina (unexpected chest pain while at rest) occur each year.

• 27% of men and 14% of women will develop angina within 6 years after a recognized heart attack.

• Only 20% of coronary attacks are preceded by long-standing angina. The percentage is lower if the infarction is silent or unrecognized.

• The age-adjusted prevalence of angina is greater in women than in men. Angina rates in women age 20 and older are 3.9% for non-Hispanic white women, 6.2% for non-Hispanic black women and 5.5% for Mexican-American women. Rates for men in these three groups are 2.6, 3.1 and 4.1%, respectively.

• The annual rates per 1,000 population of new and recurrent episodes of angina for non-black men are 44.3 for ages 65-74, 56.4 for ages 75-84, and 42.6 for age 85 and older. For non-black women in the same age groups the rates are 18.8, 30.8 and 19.8, respectively. For black men the rates are 26.1, 52.2 and 43.5, and for black women the rates are 29.4, 37.7 and 15.2, respectively.

• About 35,000 males and 47,000 females diagnosed with angina pectoris were discharged from hospitals in 1999.

 

STROKE

Stroke killed 167,366 people in 1999 and accounted for about 1 of every 14.3 deaths in the United States. About 47% of these deaths occurred out of hospital. Total mention mortality — about 278,000.

• When considered separately from other cardiovascular diseases, stroke ranks as the third leading cause of death, behind diseases of the heart and cancer.

• On average, someone in the United States suffers a stroke every 53 seconds; every 3.1 minutes someone dies of one.

• Each year, about 600,000 people suffer a new or recurrent stroke. About 500,000 of these are first attacks, and 100,000 are recurrent attacks.

• The most common variety of complete stroke is atherothrombotic brain infarction, which accounts for 61% of all strokes. The next most common is cerebral embolus (24%).

• Of incident definite or probable strokes reported in the NHLBI’s ARIC study, 83% were ischemic, 10% were intracerebral hemorrhage, and 7% were subarachnoid hemorrhage. Among the 178 definite thrombotic brain infarctions, 38% were classified as lacunar strokes (in small blood vessels) and twice as many were in blacks as in whites (Stroke. 1999;30:736-743).

• 7.6% of ischemic strokes and 37.5% of hemorrhagic strokes result in death within 30 days (Stroke 1999;30:736-743).

• About 4,600,000 stroke survivors (2,300,000 males and 2,300,000 females) are alive today.

• From 1989 to 1999, the stroke death rate fell 13.0%, but the actual number of stroke deaths rose 8.6%.

 

Age, Sex, Race and Ethnicity

• According to the NHLBI’s Framingham Heart Study…

— 28% of people who suffer a stroke in a given year are under age 65.

— For people over age 55, the incidence of stroke more than doubles in each successive decade.

— The chance of having a stroke before age 70 is 1 in 20 for both sexes.

• Stroke is more common in men than in women. In most age groups, more men than women will have a stroke in a given year. At older ages, the incidence is higher in women than in men. More than half of total stroke deaths occur in women.

• 1999 stroke mortality: males — 64,485 deaths (38.5% of deaths from stroke); females — 102,881 deaths (61.5% of deaths from stroke).

• The 1999 overall death rate for stroke was 61.8. Death rates were 60.0 for white males and 87.4 for black males, 58.7 for white females and 78.1 for black females.

• 1999 preliminary death rates for stroke were 40.0 for Hispanics, 39.7 for American Indians/Alaska Natives and 52.4 for Asian/Pacific Islanders.

• Based on the NHLBI’s ARIC study, the age-adjusted stroke incidence rates (per 1,000 person-years) are 1.78 for white men, 4.44 for black men, 1.24 for white women and 3.10 for black women. Blacks have a 38% greater risk of incident (first) strokes than whites (Stroke 1999;30:736-743).

• Among Americans age 20 and older, the age-adjusted prevalence of stroke for non-Hispanic whites is 2.2% for men and 1.5 for women; for non-Hispanic blacks it’s 2.5% for men and 3.2 for women; and for Mexican Americans it’s 2.3% for men and 1.3 for women.

• The prevalence of TIAs in men is 2.7% for ages 65 - 69 and 3.6% for ages 75-79. (A TIA or transient ischemic attack is a mini-stroke that lasts less than 24

hours.) For women, TIA prevalence is 1.6% for ages 65-69 and 4.1% for ages 75-79.

• The annual rates per 1,000 population of new and recurrent strokes for non-black men are 14.4 for ages 65-74, 24.6 for ages 75-84, and 27.9 for age 85 and older. For non-black women in the same age groups the rates are 6.2, 22.7 and 30.6, respectively. For black men the rates are 11.9, 17.5 and 40.8, and for black women the rates are 16.1, 22.4 and 0.0, respectively. 

• Compared with Caucasians, young African Americans have 2-3 times the risk of ischemic stroke, and African - American men and women are more likely to die of

stroke (Stroke. 1988;19:1-9).

• The annual rates (per 1,000) of new and recurrent strokes in American Indians ages 65-74 are 15.2 for men and 7.9 for women.

• The average annual incidence rates (per 1,000) of stroke in Japanese-American men increased with advancing age from 45-49 to 65-68 at the initial examination: 2.1 to 8.2 for total stroke, 1.5 to 6.6 for thromboembolic stroke; and 0.4 to 1.0 for intracerebral hemorrhage.

— The age-adjusted annual incidence rate (per 1,000) has declined markedly for total stroke from 5.1 to 2.4; for thromboembolic stroke, from 3.5 to 1.9; and for hemorrhagic stroke, from 1.1 to 0.6.

— Among non-Hispanic blacks, the relative risk is 4 times higher at ages 35-54, 3 times higher at ages 55-64 and almost 2 times higher at ages 65-74. The risk is only 1.2 times higher at ages 75-84 and slightly lower at age 85 and older.

— Among American Indians/Alaska Natives, the relative risk is almost 2 times higher at ages 35-44, 1.3 times higher at ages 45-54 and 1.5 times higher at ages 55-64. The risk is slightly less at ages 65-84 and less than half at age 85 and older.

— Among Asian/Pacific Islanders, the relative risk is 1.3 times higher at ages 35-54 and 1.4 times higher at ages 55-64. The risk is about the same at ages 65-84 and slightly lower at age 85 and older.

— Among Hispanics, the relative risk is about 1.3 times higher at ages 35-64 and slightly lower at ages 65-74. The risk is about half that of non-Hispanic whites at age 75 and older.

 

Aftermath

• Stroke is a leading cause of serious, long-term disability in the United States.

• In 1999 there were more than 1,100,000 American adults who reported difficulty with functional limitations, activities of daily living, etc. resulting from stroke.

• According to the NHLBI’s Framingham Heart Study…

— The length of time to recover from a stroke depends on its severity. 50 to 70% of stroke survivors regain functional independence, but 15 to 30% are permanently disabled. Institutional care is required by 20% at three months after onset.

— 22% of men and 25% of women who have an initial stroke die within a year. This percentage is higher among people age 65 and older.

— 8% of men and 11% of women will have a stroke within 6 years after a myocardial infarction.

— 51% of men and 53% of women under age 65 who have a stroke die within 8 years.

— 14% of persons who survive a first stroke or TIA will experience a recurrence within 1 year.

• 434,000 males and 527,000 females were discharged from hospitals in 1999 after having a stroke. From 1979 to 1999 these discharges increased 28.8%.

• In 1998, $3.6 billion ($5,912 per discharge) was paid to Medicare beneficiaries discharged from short-stay hospitals for stroke.

 

Blood Pressure

High blood pressure (HBP or hypertension) was listed on death certificates as the primary cause of death of 42,997 Americans in 1999. HBP was listed as a primary or contributing cause of death in about 227,000 of the more than 2,000,000 U.S. deaths that year.

• About 50,000,000 Americans age 6 and older have HBP, defined as systolic pressure of 140 mm Hg or higher or diastolic pressure of 90 mm Hg or higher, or taking antihypertensive medicine.

• 1 in 5 Americans (and 1 in 4 adults) has HBP.

• The cause of 90-95% of the cases of HBP isn’t known; however, HBP is easily detected and usually controllable.

• People with lower educational and income levels tend to have higher levels of blood pressure.

• From 1989 to 1999 the age-adjusted death rate from HBP increased 21%, but the actual number of deaths rose 46%.

• Of those with HBP, 31.6% are unaware they have it; 27.4% are on medication and have it controlled; 26.2% are on medication but don’t have their HBP under control; and 14.8% aren’t on medication.

 

Age, Sex, Race and Ethnicity

• Ahigher percentage of men than women have HBP until age 55. From ages 55-74 the percentage of women is somewhat higher; after that a higher percentage of women have HBP than men do.

• 1999 HBP mortality: males — 17,194 deaths (40.0% of deaths from HBP); females — 25,803 deaths (60.0% of deaths from HBP).

• The 1999 overall death rate from HBP was 15.9. Death rates were 12.8 for white males, 46.8 for black males, 12.8 for white females and 40.3 for black females.

• HBP is 2-3 times more common in women taking oral contraceptives, especially in obese and older women, than in women not taking them.

• About one-half of people who have a first heart attack and two-thirds who have a first stroke have blood pressures higher than 160/95 mm Hg.

• The prevalence of HBP among blacks and whites in the southeastern United States is greater and death rates from stroke are higher than among those in other regions.

• As many as 30% of all deaths in hypertensive black men and 20% of all deaths in hypertensive black women may be attributable to HBP.

• The prevalence of hypertension in blacks in the United States is among the highest in the world. Compared with whites, blacks develop HBP earlier in life and their average blood pressures are much higher. As a result, compared with whites, blacks have a 1.3 times greater rate of nonfatal stroke, a 1.8 times greater rate of fatal stroke, a 1.5

times greater rate of heart disease death and a 4.2 times greater rate of end-stage kidney disease.

• Compared with white women, black women have an 85% higher rate of ambulatory medical care visits for hypertension.

• Among U.S. adults age 20 and older, the age-adjusted prevalence of HBP for non-Hispanic whites is 25.2% for men and 20.5 for women; for non-Hispanic blacks it’s 36.7% for men and 36.6 for women; and for Mexican Americans it’s 24.2% for men and 22.4 for women.

• The age-adjusted (1980 standard) prevalence of HBP for Asian/Pacific Islanders is 9.7% for men and 8.4% for women.

• Among American Indians ages 45-74, 26.8% of men and 27.5% of women have HBP. (Defined as definite hypertension: systolic blood pressure of 160 mm Hg or greater or diastolic blood pressure of 95 mm Hg or greater on one occasion or reported to be currently taking antihypertensive medication.)

• 73% of Japanese-American men ages 71-93 have HBP.

• Among Americans age 18 and older, the median percentages who have been told by a professional that they have high blood pressure are:

— For whites, 23.0%.

— For blacks, 30.9%.

— For Hispanics, 18.6%.

— For Asian/Pacific Islanders, 16.3%.

— For American Indians/Alaska Natives, 20.7%.

 

Discharges

• 172,000 males and 267,000 females diagnosed with HBP were discharged from hospitals in 1999.

 

End-Stage Renal Disease (ESRD)

ESRD (also called end-stage kidney disease) is a condition closely related to high blood pressure. ESRD morbidity rates vary dramatically among different age, race, ethnicity and sex population groups. Morbidity rates tend to increase with age, then fall off for the oldest age group. The largest 5-year age group for incidence is patients ages 70-74; for prevalence, it’s ages 65-69. The excess CVD risk in people with chronic renal disease is caused, in part, by a higher prevalence of CVD risk factors in this group than in the general population. The main factors include older age, high blood pressure, high blood cholesterol and lipids, diabetes and physical inactivity.

• In 1999, the estimated incidence of new ESRD patients was 89,252.

• 344,094 patients were being treated for ESRD by the end of 1999.

• 66,964 patients died from ESRD in 1999.

• More than 13,590 kidney transplants were performed in 1999.

• Diabetes continues to be the most common reported cause of ESRD.

• The incidence of reported ESRD therapy has almost doubled in the past 10 years.

 

Age, Sex, Race and Ethnicity

• The average incidence rates for pediatric ESRD are more than twice as high among children 15-19 years as for children 10-14 years. The rates are more than 3 times higher than those for children ages 0-4 and 5-9.

• Children with pediatric ESRD have high transplantation rates. More than 44% of children starting therapy received a transplant during the first year of therapy, compared with 10% of patients 20-64 years of age at ESRD incidence.

• Treatment of ESRD is more common in men than in women.

• Blacks and Native Americans have much higher rates of ESRD than whites and Asians. Blacks represent 32% of treated ESRD patients.

 

Arrhythmias (Disorders of Heart Rhythm)

Mortality — 39,262. Total mention mortality — about 500,000 of the more than 2,000,000 U.S. deaths. Hospital discharges — 761,000. In 1998, $2.1 billion ($6,047 per discharge) was paid to Medicare beneficiaries for cardiac arrhythmias.

• Atrial fibrillation and flutter.

Mortality — 8,338. Total mention mortality — more than 61,500. Prevalence — 2,000,000. Hospital discharges — 384,000. A higher percentage of men than women have atrial fibrillation, but the actual numbers of men and women with it are about equal. About 70% of people with atrial fibrillation are between 65 and 85 years old (Archives of Internal Medicine, 1995;155:469-473). About 15% of strokes occur in people with atrial fibrillation.

• Tachycardia (ICD/9 427.0,1,2) (ICD/10 I47.0,1,2,9). Mortality — 683. Total mention mortality — more than 6,800. Prevalence in 1996 — 2,300,000. Hospital discharges — 92,000. — Paroxysmal supraventricular tachycardia. Mortality — 27. Hospital discharges — 28,000.

• Ventricular fibrillation.

Mortality — 1,626. Total mention mortality — 21,300.

Hospital discharges — 9,000. Although ventricular fibrillation is listed as the cause of relatively few deaths, the overwhelming number of sudden cardiac deaths from coronary disease (which are estimated at about 250,000 per year) are thought to be from ventricular fibrillation.

 

Artery Diseases

Mortality — 40,788. Total mention mortality — 124,100. Hospital discharges — 287,000.

• Atherosclerosis  is a process that leads to a group of diseases characterized by a thickening of artery walls. Mortality — 14,979. Hospital discharges

— 120,000. Atherosclerosis is also a leading cause of many deaths from heart attack and stroke. As such, it accounts for nearly three-fourths of all deaths from CVD.

• Aortic aneurysm. Mortality — 15,807. Total mention mortality — 22,400. Hospital discharges — 63,000.

• Other diseases of arteries. Mortality — 10,002. Hospital discharges — 104,000. — Kawasaki disease.

Mortality — 2. Up to 2,500 cases of Kawasaki disease are diagnosed yearly. Hospital discharges — 15,000, primary plus secondary diagnoses.

• About 80% of patients with Kawasaki disease are under age 5; most are under age 2. Children older than 8 years are rarely affected.

• Kawasaki disease occurs more often among boys (63%) and among those of Asian ancestry.

 

Bacterial Endocarditis

1998 total mention mortality — 2,212. Hospital discharges — 17,000, primary plus secondary diagnoses.

 

Cardiomyopathy

Mortality — 27,260. Total mention mortality — 53,700. Hospital discharges — 35,000.

• 87% of cases are congestive or dilated cardiomyopathy. 50% of patients with dilated cardiomyopathy are alive 5 years after their initial diagnosis; 25% are alive 10 years after the diagnosis.

• Recent studies show that 36% of young athletes who die suddenly have probable or definite hypertrophic cardiomyopathy.

• Mortality from cardiomyopathy is highest in older persons, men and blacks.

 

Congenital Cardiovascular Defects

Mortality — 4,436. Total mention mortality — about 6,700. Hospital discharges — 54,000.

• About 40,000 babies are born each year with cardiovascular defects. (Metropolitan Atlanta Congenital Defects Program.

• At least 35 distinct types of defects are recognized, ranging from simple defects to complex malformations. Common defects diagnosed in infancy include ventricular septal defect (14-17%), tetralogy of Fallot (9-12%), transposition of the great arteries (10-11%), atrioventricular septal defect (4-10%) and coarctation of the aorta (8-11%). Most defects can be corrected or improved with surgery or catheter-based therapy.

• About 1,000,000 Americans with congenital cardiovascular defects are alive today.

• Mortality associated with congenital defects has been declining. From 1979-97, death rates from all defects declined 39%. More than half of deaths occur in infants less than 1 year old. Mortality varies considerably according to type of defect (Circulation. 2001;103:2376-2381).

• More deaths occur due to cardiac defects than to any other birth defect (Genetic Epidemiology. 1997;14:493-505).

• The 1999 overall death rate for congenital cardiovascular defects was 1.6. Death rates were 1.7 for white males, 2.3 for black males, 1.5 for white females and 1.8 for black females. Crude infant death rates (under 1 year) were 46.4 for white babies and 61.0 for black babies. Some types of defects occur more commonly in females or males.

• From 1989 to 1999, death rates for congenital cardiovascular defects declined 31.5%, while the actual number of deaths declined 22.7%.

 

Congestive Heart Failure

Mortality — 50,824; males — 18,987 (37.4% of total deaths from CHF); females — 31,837 (62.6% of total deaths from CHF). Total mention mortality — 287,200. Hospital discharges — 430,000 males and 532,000 females. From 1979 to 1999, these discharges increased 155.2%.

• About 4,790,000 Americans (2,360,000 males and 2,440,000 females) have CHF and are alive today.

• The age-adjusted prevalence of CHF among non-Hispanic whites age 20 and older is 2.3% for men and 1.5% for women. For non-Hispanic blacks, the percentages are 3.5 for men and 3.1 for women.

— About 550,000 new cases of CHF occur each year.

— The incidence of CHF approaches 10 per 1,000 population after age 65.

— 75% of CHF cases have antecedent hypertension.

— About 22% of male and 46% of female heart attack (MI) victims will be disabled with heart failure within 6 years.

— 80% of men and 70% of women under age 65 who have CHF will die within 8 years.

— After CHF is diagnosed, survival is poorer in men than in women, but fewer than 15% of women survive more than 8-12 years. Their 1-year mortality rate is higher with 1 in 5 dying.

— In people diagnosed with CHF, sudden cardiac death occurs at 6-9 times the rate of the general population.

• From 1979 to 1999, CHF deaths increased 145%.

• The 1999 overall death rate for CHF was 18.8. Death rates were 19.4 for white males, 21.9 for black males, 18.2 for white females and 19.4 for black females.

• Hospital discharges for CHF rose from 377,000 in 1979 to 962,000 in 1999.

• The annual rates per 1,000 population of new and recurrent CHF events for non-black men are 21.5 for ages 65-74, 43.3 for ages 75-84, and 73.1 for age 85 and older. For non-black women in the same age groups the rates are 11.2, 26.3 and 64.9, respectively. For black men the rates are 21.1, 52.0 and 66.7, and for black women the rates are 18.9, 33.5 and 48.4, respectively.

• In 1998, $3.6 billion ($5,471 per discharge) was paid to Medicare beneficiaries for CHF.

 

Rheumatic Fever/Rheumatic Heart Disease

Mortality — 3,676; males — 1,042 deaths (28.4% of total deaths from RF/RHD); females — 2,634 deaths (71.6% of total deaths from RF/RHD). Total mention mortality — about 9,000. Hospital discharges — 45,000.

• In 1950 about 15,000 Americans (adjusted for changes in ICDA codes) died of these diseases compared with about 4,000 today.

• From 1989 to 1999 the death rate from RF/RHD fell 34.6%, while actual deaths declined 26.4%.

• The 1999 overall death rate for RF/RHD was 1.4. Death rates were 0.9 for white males and 0.8 for black males, 1.7 for white females and 1.2 for black females.

• Many of the 96,000 annual operations on heart valves are related to rheumatic heart disease.

• The incidence of rheumatic fever remains higher in African Americans, Puerto Ricans, Mexican Americans and American Indians.

• In developing countries, rheumatic fever is the most frequent cause of heart disease in the 5-13-year-old group, causing 25-40% of all cardiovascular diseases and

33-50% of all hospital admissions.

 

Valvular Heart Disease

Mortality — 19,612. Total mention mortality — 39,500. Hospital discharges — 97,000.

• Aortic valve disorders.

Mortality — 12,212. Total mention mortality — about 11,609. Hospital discharges — 52,000.

• Mitral valve disorders.

Mortality — 2,895. Total mention mortality — about 6,100. Hospital discharges — 43,000.

— The NHLBI’s Framingham Heart Study reports that prevalence is about 1-2% and no more common in women than in men. This was a study of people ages 26-84.

• Pulmonary valve disorders.

Mortality — 10.

• Tricuspid valve disorders.

Mortality — 5.

 

Tobacco Smoke

• For the years 1990-94, an average of 430,700 Americans died each year of smoking-related illnesses. The largest portion of these deaths was cardiovascular-related.

• About 1 in 5 deaths from cardiovascular diseases is attributable to smoking. About 37,000-40,000 nonsmokers die from CVD each year as a result of exposure to environmental tobacco smoke.

• Smoking costs Americans an estimated $130 billion annually in medical care. This includes the effects of smoking during pregnancy, lost workdays, lost output from early death and retirement, and fires caused by smoking.

• Studies show that among people age 18 and older in the United States, smoking has declined by about 44% since 1965. Recent data indicate that this downward trend may have leveled off.

• Global mortality from tobacco use is projected to rise from 3 million deaths in 1990 to 10 million in 2030.

• According to the WHO, 1 year after quitting, the risk of coronary heart disease decreases by 50%, and within 15 years, the relative risk of dying from CHD for an exsmoker approaches that of a long-time (lifetime) nonsmoker.

• A recent study indicates that passive smoking substantially reduces coronary flow velocity reserve in healthy young adults (JAMA. 2001;286:436-441).

 

Age, Sex, Race and Ethnicity

• During 1988-96, among people 12-17 years old, the incidence of initiation of first use increased by 30%, and first daily use increased by 50%. More than 6,000 people under age 18 try a cigarette each day, and each day more than 3,000 persons under age 18 become daily smokers. If trends continue, about 5 million of these people will eventually die from a disease attributed to smoking.

• According to 1999 data from the National Youth Tobacco Survey, 29.3% of middle school students and 63.5% of high school students reported ever smoking cigarettes; 15.4% and 41.6% reported ever smoking cigars; and 7.1% and 18.2% reported ever using smokeless tobacco, respectively.

• In 1996 about 15 million children and adolescents under age 18 were exposed to environmental tobacco smoke in the home.

• About 80% of people who use tobacco begin before age 18, with the most common ages of initiation being 14 to 15 (MMWR, Vol. 48, No. 31, Aug. 1999, CDC/NCHS).

• White youths ages 18-24, from families with lower educational attainment, report substantially higher smoking rates than black and Mexican-American youths from families with similar educational attainment. 77% of young white men and 61% of young white women are current smokers compared with 35% of minority youth (JAMA. 1999;281:1006-1013).

• From 1980 to 1997, the percentage of high school seniors who smoked in the past month increased almost 20%. For males it was 39.2%, and for females it was 5.4%. For whites it was 37.1%, while for blacks there was a 41% decrease.

• Current age-adjusted prevalence for Americans age 18 and older shows 25,030,000 men (25.7%) and 22,640,000 women (21.5%) are smokers, putting them at increased risk of heart attack and stroke.

• 1999 National Health Interview Survey (NHIS) data from

CDC/NCHS for persons age 18 and older show...

— Among non-Hispanic whites, 25.5% of men and 23.1% of women smoke.

— Among non-Hispanic blacks, 28.7% of men and 20.8% of women smoke.

— Among Hispanics, 24.1% of men and 12.3% of women smoke.

— Among Asian/Pacific Islanders, 24.3% of men and 7.1% of women smoke.

— Among American Indians/Alaska Natives, 40.9% of men and 40.8% of women smoke.

• Among American Indians ages 45-74, 40.5% of men and 29.3% of women are current smokers.

• Studies show that smoking prevalence is higher among those with 9-11 years of education (35.4%) compared with those with more than 16 years of education (11.6%) and is highest among persons living below the poverty level (33.3%).

• 47.7% of working adults age 17 and older who don’t use tobacco report exposure to environmental tobacco smoke at home or at work (JAMA. 1995;273:402-407).

• 37.4% of nonsmoking adults are exposed to environmental tobacco smoke at home or at work. The ethnic breakdown is 37.4% of non-Hispanic whites, 36.9% of non-Hispanic blacks and 35.1% of Mexican Americans (JAMA. 1996;275:1233-1240).

• The risk of death from CHD increases by up to 30% among those exposed to environmental tobacco smoke at home or work.

• The proportion of adults who report that their workplace has an official smoke-free policy ranges from 61.3% to 82.1%. As the respondents’ level of education increases, they are more likely to report working under a smoke-free policy.

 

High Blood Cholesterol and Other Lipids

An estimated 102,340,000 American adults have total blood cholesterol levels of 200 milligrams per deciliter (mg/dL) and higher. Of these, about 41,260,000 have levels of 240 mg/dL or above. In adults, total cholesterol levels of 240 mg/dL or higher are  considered high risk. Levels from 200 to 239 mg/dL are considered borderlinehigh risk. For information on dietary cholesterol, total fat, saturated fat and other factors that affect blood cholesterol levels, see the Nutrition section on pages 29-30.

 

• Among children and adolescents ages 4-19 years:

— Females have significantly higher average total cholesterol and low-density lipoprotein (LDL) cholesterol (“bad” cholesterol) than do males.

— Non-Hispanic black children and adolescents have significantly higher mean total cholesterol, LDL cholesterol and high-density lipoprotein (HDL) cholesterol (“good” cholesterol) levels when compared with non-Hispanic white and Mexican-American children and adolescents.

• Among children and adolescents ages 4-19, the mean total blood cholesterol level is 165 mg/dL. For boys it’s 163 mg/dL and for girls it’s 167 mg/dL. The racial/ethnic breakdown is:

— For non-Hispanic whites, 162 mg/dL for boys and 166 mg/dL for girls.

— For non-Hispanic blacks, 168 mg/dL for boys and 171 mg/dL for girls.

— For Mexican Americans, 163 mg/dL for boys and 165 mg/dL for girls.

• About 10% of adolescents ages 12-19 have total cholesterol levels exceeding 200 mg/dL.

• The prevalence of cholesterol screening during the preceding 5 years increased from 67.3% in 1991 to 70.8% in 1999.

• A 10-percent decrease in total cholesterol levels may result in an estimated 30% reduction in the incidence of CHD.

• Among Americans age 18 and older, the median percentages who have been told by a professional that they have high blood cholesterol are:

— For whites, 29.7%.

— For blacks, 26.0%.

— For Hispanics, 25.6%.

— For Asian/Pacific Islanders, 27.3%.

— For American Indians/Alaska Natives in Alaska, 26.0%; in Oklahoma, 28.6%; in Washington, 26.5%.

• Studies show that a higher percentage of women than men have total blood cholesterol of 200 mg/dL or higher, beginning at age 50.

• 53,830,000 adult women and 48,180,000 adult men had total blood cholesterol levels of 200 mg/dL or higher in 1999.

• Age-adjusted prevalence among non-Hispanic whites ages 20-74:

— 52% of men and 49% of women have total blood cholesterol levels over 200 mg/dL.

— 18% of men and 20% of women have total blood cholesterol levels of 240 mg/dL or higher.

• Age-adjusted prevalence among non-Hispanic blacks ages 20-74:

— 45% of men and 46% of women have total blood cholesterol levels over 200 mg/dL.

— 15% of men and 18% of women have total blood cholesterol levels of 240 mg/dL or higher.

• Age-adjusted prevalence among Mexican Americans ages 20-74:

— 53% of men and 48% of women have total blood cholesterol levels over 200 mg/dL.

— 18% of men and 17% of women have total blood cholesterol levels of 240 mg/dL or higher.

• Among elderly Japanese-American men, 42% have total cholesterol levels of 200 mg/dL or higher or are taking cholesterol-lowering medication.

 

Trends in Mean Total Blood Cholesterol Among Adolescents Ages 12-17 by Sex, Race and Survey

• For American Indians ages 45-74, 37.7% of men and 37.6% of women have total blood cholesterol levels of 200 mg/dL or higher. 8.6% of men and 12.7% of women have levels of 240 mg/dL or higher.

 

LDL (“Bad”) Cholesterol

• Mean LDL cholesterol levels among children and adolescents ages 12-19 are:

— Among non-Hispanic whites, 91 mg/dL for boys and 100 mg/dL for girls.

— Among non-Hispanic blacks, 99 mg/dL for boys and 102 mg/dL for girls.

— Among Mexican Americans, 93 mg/dL for boys and 92 mg/dL for girls.

• The age-adjusted prevalence among Americans age 20 and older with LDL cholesterol levels of 130 mg/dL or higher, which is associated with a higher risk of coronary heart disease, is:

— For non-Hispanic whites, 49.6% of men and 43.7% of women. (20.4% of men and 17.0% of women have an LDL cholesterol level of 160 mg/dL or higher.)

— For non-Hispanic blacks, 46.3% of men and 41.6% of women (19.3% of men and 18.8% of women have an LDL cholesterol level of 160 mg/dL or higher.).

— For Mexican Americans, 43.6% of men and 41.6% of women. (16.9% of men and 14.0% of women have an LDL cholesterol level of 160 mg/dL or higher.)

 

HDL (“Good”) Cholesterol

• Mean HDL cholesterol levels among children and adolescents ages 4-19 are:

— Among non-Hispanic whites, 48 mg/dL for boys and 50 mg/dL for girls.

— Among non-Hispanic blacks, 55 mg/dL for boys and 56 mg/dL for girls.

— Among Mexican Americans, 51 mg/dL for boys and 52 mg/dL for girls.

• The age-adjusted prevalence among Americans age 20 and older with HDL cholesterol of less than 40 mg/dL, which is associated with a higher risk of coronary heart disease, is:

— For non-Hispanic whites, 40.5% of men and 14.5% of women.

— For non-Hispanic blacks, 24.3% of men and 13.0% of women.

— For Mexican Americans, 40.1% of men and 18.4% of women.

• The risk of myocardial infarction (heart attack) in both men and women is highest at lower HDL cholesterol (HDL-C) levels and higher total cholesterol levels, overall. However, those with lower levels of HDL-C (37 mg/dL or lower in men and 47 mg/dL or lower in women) are at a high risk regardless of their total cholesterol level. Conversely, those with high levels of total cholesterol have lower risks of myocardial infarction when accompanied by higher levels of HDL-C (53 mg/dL or greater in men and 67 mg/dL or greater in women). This suggests the importance of screening for both total and HDL cholesterol levels in adults.

 

Physical Inactivity

The following data are based on leisure-time physical activity.

• In 1998 about 29% of Americans age 18 or older reported no leisure-time physical activity. 27% achieved recommended levels of physical activity. 44% reported some activity but not enough to achieve recommended levels.

— Men, young people and whites had a higher prevalence of recommended levels of activity compared with women, older people and people from minority races or ethnic groups.

— People who were college-educated, in high income brackets or living in the West had a higher prevalence of recommended activity.

• The relative risk of CHD associated with physical inactivity ranges from 1.5 to 2.4, an increase in risk comparable to that observed for high blood cholesterol, high blood pressure or cigarette smoking. (JAMA. 1995;273:402-407)

• Less-active, less-fit persons have a 30-50% greater risk of developing high blood pressure. (Cardiovascular benefits and assessment of physical activity and physical fitness in adults. Med Sci Sports Exerc 1992;24(suppl 6):S201-S220)

 

Age, Sex, Race and Ethnicity

• Daily enrollment in physical education classes among high school students has declined from 42% in 1991 to 29.1% in 1999.

• 56.1% of high school students were enrolled in physical education classes in 1999, but only 29.1% attended classes daily.

• Physical inactivity is more prevalent among women than men, among blacks and Hispanics than whites, among older than younger adults and among the less affluent

than the more affluent.

• Among American Indians ages 45-74, 16.8% of men and 19.6% of women report no physical activity during the past year.

• Among adults age 18 and older, the following proportions of people are sedentary (have no leisure-time physical activity):

— For non-Hispanic whites, 33.3% of men and 38.9% of women.

— For non-Hispanic blacks, 46.0% of men and 57.1% of women.

— For Hispanics, 49.9% of men and 57.1% of women.

— For non-Hispanic Asian/Pacific Islanders, 36.2% of men and 49.2% of women.

• Arecent study of over 72,000 female nurses indicates that moderate-intensity physical activity such as walking is associated with a substantial reduction in risk of total and

ischemic stroke when compared with physical activity done at an average or casual pace (JAMA. 2000;283:2961-2967).

• The prevalence of physical inactivity during leisure time among Mexican Americans is higher than in the general population.

— The prevalence of physical inactivity among those whose main language is English is 15% of men and 28% of women. This is similar to that of the general population (17% of men and 27% of women).

— Those whose main language is Spanish have the highest prevalence of physical inactivity (38% of men and 58% of women).

 

Overweight and Obesity

Using a body mass index (BMI) of 25.0 or higher as “overweight” and a BMI of 30.0 or higher as “obese,” 108,330,000 Americans age 20 and older are considered overweight (56,350,000 men and 51,980,000 women). Of these, 44,250,000 are considered obese (18,680,000 men and 25,570,000 women). In addition, an estimated 5,030,000 children ages 6-17 are considered overweight (based on the 95th percentile of BMI values in the 2000 CDC growth chart for the U.S.).

• Using the 95th percentile of BMI values, the prevalence of overweight among American children ages 6-11 is:

— For non-Hispanic whites, 10.3% of boys and 9.2% of girls.

— For non-Hispanic blacks, 11.9% of boys and 16.4% of girls.

— For Mexican Americans, 17.4% of boys and 14.3% of girls.

• Using the 95th percentile of BMI values, the prevalence of overweight among American adolescents ages 12-17 is:

— For non-Hispanic whites, 11.1% of boys and 8.5% of girls.

— For non-Hispanic blacks, 10.7% of boys and 15.7% of girls.

— For Mexican Americans, 14.6% of boys and 13.7% of girls.

• Each year an estimated 300,000 U.S. adults die of causes related to obesity (JAMA 1999;282:1530-1538).

• Among Americans age 18 and older, the following people are overweight (defined as a BMI of 25 kg/m2 or higher):

— For non-Hispanic whites, 62.4% of men and 43.0% of women.

— For non-Hispanic blacks, 64.1% of men and 64.5% of women.

— For Hispanics, 64.7% of men and 56.8% of women.

— For non-Hispanic Asian/Pacific Islanders, 35.2% of men and 25.2% of women.

• Among Americans age 18 and older, the median percentages of obesity are (defined as a BMI greater than 30 kg/m2):

— For whites, 15.6%.

— For blacks, 26.4%.

— For Hispanics, 18.2%.

— For Asian/Pacific Islanders, 4.8%.

— For American Indians/Alaska Natives, 30.1%.

 

Prevalence of Moderate or Vigorous Physical Activity in Americans Age 20 and Older by Sex, Race/Ethnicity and BMI*

• Among Americans ages 20-74 (with a BMI of 25.0 or higher to indicate overweight and a BMI of 30.0 or higher to indicate obesity), the age-adjusted prevalences are:

— For non-Hispanic whites, 61.5% of men and 46.8% of women are overweight. 20.8% of men and 23.2% of women are obese.

— For non-Hispanic blacks, 58.4% of men and 68.3% of women are overweight. 21.3% of men and 38.2% of women are obese.

— For Mexican Americans, 69.3% of both men and women are overweight. 24.8% of men and 36.1% of women are obese.

• Among American Indians ages 45-74, 25.9% of men and 31.3% of women are overweight (defined as a BMI of 27.8-31.0 for men and 27.3-32.2 for women). 35.5% of men and 41.2% of women are obese (defined as a BMI of 31.1 or higher for men and 32.3 or higher for women).

• The prevalence of obesity (BMI of 30 kg/m2 or higher) was 19.8% in 2000. Mississippi had the highest prevalence of obesity (24.3%) and Colorado had the lowest (13.8%) (JAMA 2001;286:1195-1200).

• An expert group convened by the World Health Organization in June 1997 found that overweight and obesity represent a rapidly growing threat to the health of populations in an increasing number of countries worldwide. WHO recognized obesity as a disease that is prevalent in both developing and developed countries and that affects children and dults alike.

 

Mean BMI for Women* Ages 25-64 by Education and Race/Ethnicity, Diabetes Mellitus

In 1999 diabetes killed 68,399 Americans. Males — 31,150 deaths (45.5% of total deaths from diabetes); females — 37,249 deaths (54.5% of total deaths from diabetes). Total mention mortality — 202,000.

• 10,600,000 Americans have physician-diagnosed diabetes (about 4,900,000 males and 5,700,000 females) (Diabetes Care 1998;21:518-524).

• The prevalence of diabetes rose from 4.9% in 1990 to 6.5% in 1998, an increase of 33.3%. Increases were observed in both sexes, all ages, all ethnic groups, all education levels, and nearly all states (Diabetes Care 2000;23:1278-1283).

• The prevalence of diabetes was 7.3% in 2000. Mississippi had the highest prevalence of diabetes (8.8%) and Alaska had the lowest (4.4%) (JAMA 2001;286:1195-1200).

• 798,000 new cases of non-insulin dependent diabetes are diagnosed every year according to estimates of the National Institute of Diabetes, Digestive, and Kidney Diseases.

• 545,000 Americans diagnosed with diabetes mellitus were discharged from hospitals in 1999. Of these, about 262,000 were males and 283,000 were females.

• The 1999 overall death rate from diabetes was 25.2. Death rates were 25.8 for white males, 48.6 for black males, 20.5 for white females and 50.4 for black females.

• Two-thirds of people with diabetes mellitus die of some form of heart or blood vessel disease.

• The age-adjusted prevalence of physician-diagnosed diabetes in adults age 20 and older is:

— For non-Hispanic whites, 5.4% of men and 4.7% of women.

— For non-Hispanic blacks, 7.6% of men and 9.5% of women.

— For Mexican Americans, 8.1% of men and 11.4% of women.

• Among Americans age 18 and older, the median percentages who have be told by a professional that they have diabetes are:

— For whites, 4.4%.

— For blacks, 7.6%.

— For Hispanics, 5.5%.

— For Asian/Pacific Islanders, 4.6%.

— For American Indians/Alaska Natives, 7.6%.

• Among American Indians ages 45-74, 43.5% of men and 52.4% of women have diabetes mellitus. Also, 14.2% of men and 17.4% of women have impaired glucose tolerance.

• 17% of Japanese-American men ages 71-93 have diabetes. In addition, 19% have unrecognized diabetes, and 32% have impaired glucose tolerance.

• The risk of diabetes for Mexican Americans and non-Hispanic blacks is almost twice that for non-Hispanic whites (Diabetes Care 1998;21:518-524).

• Compared with white women, black women have 138% higher rates of ambulatory medical care visits for diabetes.

• An estimated 5,600,000 Americans have undiagnosed diabetes — about 3,000,000 men and 2,600,000 women.

• The following age-adjusted prevalence of undiagnosed diabetes in Americans age 20 and older uses American Diabetes Association criteria of fasting plasma glucose of

126 mg/dL or more:

— For non-Hispanic whites, 3.0% of men and 2.1% of women.

— For non-Hispanic blacks, 2.8% of men and 4.7% of women.

— For Mexican Americans, 5.8% of men and 3.9% of women.

• An estimated 13,800,000 Americans have impaired fasting glucose — about 8,400,000 men and 5,500,000 women.

• The following age-adjusted prevalence of impaired fasting glucose among Americans age 20 and older uses American Diabetes Association criteria of fasting plasma

glucose of 110 to less than 126 mg/dL:

— For non-Hispanic whites, 9.4% of men and 4.8% of women.

— For non-Hispanic blacks, 8.0% of men and 6.8% of women.

— For Mexican Americans, 12.1% of men and 6.7% of women.

• The prevalence of diabetes in adults globally was estimated to be 4.0% in 1995 and was predicted to rise to 5.4% by the year 2025. The number of adults with

diabetes in the world is estimated to rise from 135 million in 1995 to 300 million in 2025 (Diabetes Care 1998;21:1414-1431).

— It’s projected that the number of people with diabetes will increase 42%, from 51 million to 72 million, in developed countries and 170%, from 84

million to 228 million, in developing countries.

— The majority of people with diabetes in developing countries is projected to be younger, ages 45-64, while those in developed countries will be age 65.

— Diabetes will be increasingly concentrated in urban areas, with the greater burden of disease among women.

 

NUTRITION

Good nutrition is important for preventing heart disease and stroke. Healthy food habits help maintain normal blood pressure, desirable blood cholesterol levels and a healthy body weight. They also may aid blood clotting, oxidation, maintaining a normal heart rhythm and other effects. A poor diet, on the other hand, contributes to high blood pressure, high blood cholesterol and excess body weight. Overweight and obesity in turn contribute to diabetes, cholesterol disorders and high blood pressure.

 

The American Heart Association recommends a diet low in saturated fat, trans fat, cholesterol and sodium. It should be high in vegetables, fruits, whole grains, legumes, fat-free or low-fat dairy products, and dietary fiber. The following data support these recommendations.

• Between 1965 and 1991 among U.S. adults age 18 and older, total daily calories declined from 2,049 to 1,807, but then rebounded to 2,000 calories in 1996. This contributed to the marked increase in obesity levels in the past decade (Prev Med 2001;32:245-254).

• Between 1965 and 1996 among adults, total fat as a proportion of daily calorie intake fell steadily from 39.1 to 33.1%. Saturated fat fell from 14.4 to 11.0%.

However, total calorie intake increased between 1991 and 1996. Over the same period daily total fat consumption rose from 70.9 grams (g) to 74.8 g (Prev Med 2001;32:245-254).

— Total fat intake (saturated, trans, monounsaturated, polyunsaturated) should be less than 30% of total daily calories.

— Saturated fat and trans fat should not exceed 10% of total daily calories for healthy people.

— Saturated fat should be less than 7% of total daily calories for people with coronary heart disease, diabetes or high LDL cholesterol.

• The average daily intake of total fat in the United States is 81.4 grams (96.5 g for males and 67.3 g for females).

— For non-Hispanic whites the average is 82.7 grams (99.0 g for males and 67.4 g for females).

— For non-Hispanic blacks the average is 82.0 grams (94.6 g for males and 71.2 g for females).

— For Mexican Americans the average is 77.6 grams (88.0 g for males and 66.5 g for females).

 

• The average daily intake of saturated fat in the U.S. is 27.9 grams (33.1 g for males and 23.0 g for females).

— For non-Hispanic whites the average is 28.4 grams (34.1 g for males and 23.1 g for females).

— For non-Hispanic blacks the average is 27.5 grams (31.7 g for males and 23.8 g for females).

— For Mexican Americans the average is 26.7 grams (30.1 g for males and 23.1 g for females).

• The proportion of fat calories from beef, pork, dairy products and eggs fell from 50% in 1965 to 33% in 1994-96. The proportion of fat calories from poultry increased from 4% to 7%. Calories from fruits and vegetables rose from 8% to 13% (Prev Med 2001;32:245-254).

• In 1994-96, pizza, Mexican food, Chinese food, hamburgers, French fries and cheeseburgers accounted for 10.8% of total fat intake. These six foods accounted for only 1.9% of fat intake in 1965 (Prev Med 2001;32:245-254).

• The major sources of saturated fat in the diet are red meat, butter, whole milk and eggs. Intake of these foods has fallen markedly since 1965. The decline in whole milk consumption from 21.3 gallons in 1972-76 to 8.2 gallons in 1997 accounts for most of the reduction in saturated fat (Prev Med 2001;32:245-254).

• The recommended daily intake of dietary cholesterol for adults is less than 300 mg. The average daily intake of dietary cholesterol in the U.S. is 269.6 milligrams (mg). For males it’s 323.5 mg and for females it’s 218.9 mg.

— For non-Hispanic whites the average is 259.3 milligrams (312.6 mg for males and 209.1 mg for females).

— For non-Hispanic blacks the average is 297.9 milligrams (358.8 mg for males and 245.6 mg for females).

— For Mexican Americans the average is 316.2 milligrams (365.9 mg for males and 263.8 mg for females).

• The recommended daily intake of dietary fiber is 25 grams or more. Americans consume a daily average of 15.6 grams of dietary fiber (17.8 g for males and 13.6 g

for females).

— For non-Hispanic whites the average is 15.8 grams (18.1 g for males and 13.7 g for females).

— For non-Hispanic blacks the average is 13.4 grams (15.0 g for males and 12.0 g for females).

— For Mexican Americans the average is 18.5 grams (21.0 g for males and 15.9 g for females).

• Only 22.7% of adults consumed fruits and vegetables at least 5 times a day in 1996. This was an increase from 19.0% in 1990.

• The highest proportion of adults who consumed fruits and vegetables at least 5 times a day were those 65 years and older, whites, college graduates, those actively engaged in leisure-time physical activity, and nonsmokers (Prev Med 2001;32:245-254).

• The percentage of men who consumed fruits and vegetables at least 5 times a day increased from 16.5% in 1990 to 19.1% in 1996. The percentage of women increased from 21.3% in 1990 to 26.2% in 1996 (Am J Public Health 2000;90:777-781).

• From 1990 to 1996, the percentage of obese adults who consumed at least 5 servings of fruits and vegetables a day dropped from 16.8% to 15.4%. (Prev Med

2001;32:245-254)

• Recent studies support the intake of up to 9 servings of fruits and vegetables per day. (Appel, et al., NEJM 1997;336:1117-1124)

 

QUALITY of Care

The National Committee for Quality Assurance has chosen 5 quality-of-care performance measures related to preventing and treating cardiovascular diseases (The State of Managed Care Quality, 2000, NCQA):

• Advising smokers to quit

• Use of beta blockers after a heart attack

• Cholesterol screening in patients with coronary heart disease

• Cholesterol control in patients with coronary heart disease

• Control of high blood pressure

Performance data for these indicators apply to patients who receive their medical care from providers in managed care plans in the United States. Evidence supports the contention that the quality of care may be better in managed care settings than in other settings. Improvements in the quality of care measured by these performance indicators would be associated with substantial reductions in morbidity and mortality related to cardiovascular diseases.

 

Advising smokers to quit

• In 1999, 65.3% of smokers were advised to quit, an increase from 61.0% of smokers in 1996.

• The 90th percentile benchmark was 73% of smokers. If all practices performed at this level, an estimated 2.7 million additional smokers would be advised to quit and 82,000 additional smokers would actually quit smoking. This would lead to substantial reductions in smokingrelated morbidity, mortality (683 fewer deaths per year) and healthcare costs.

 

Use of beta blockers after a heart attack

• In 1999, 85.0% of heart attack survivors were receiving a beta blocker at the time of discharge from the hospital, an increase from 62.2% in 1996. If all practices performed at the 90th percentile level (96%), an additional 4,000 deaths could be avoided each year.

 

Cholesterol screening in patients with coronary heart disease

• In 1999, 68.9% of patients hospitalized for heart attack, bypass surgery or angioplasty were screened for LDL cholesterol between 60 and 365 days following discharge. This proportion represented an increase from 59.1% in 1998, the first year this performance indicator was used. The 90th percentile benchmark was 83%.

 

Cholesterol control in patients with coronary heart disease

• In 1999, 45.3% of patients hospitalized for heart attack, bypass surgery or angioplasty were treated with an LDL cholesterol goal of less than 130 mg/dL. The 90th percentile benchmark was 64.4%.

• Note that this treatment goal is less aggressive than the goal endorsed by the American Heart Association and the National Cholesterol Education Program (less than 100 mg/dL). Hence, it’s likely that control to the AHA and NCEP goal is worse than suggested here.

 

Control of high blood pressure

• In 1999 only 39.0% of adults with high blood pressure were controlled to levels less than 140/90 mm Hg. The 90th percentile performance goal was 47.9%.

 

MEDICAL Procedures, Facilities and Costs

From 1979 to 1999, the number of cardiovascular operations and procedures increased 413%.

 

Cardiac Catheterization

• From 1979 to 1999, the number of cardiac catheterizations increased 355%.

• In the United States, an estimated 1,359,000 inpatient cardiac catheterizations were performed in 1999.

• 472,000 ambulatory (outpatient) surgical procedures for cardiac catheterization were performed in 1996. 298,000 of them were done on males and 175,000 on females.

 

Coronary Artery Bypass Surgery

In the United States in 1999, the NCHS estimates that 571,000 of these procedures were performed on 355,000 patients. These numbers represent both code and vessel data. Thus it’s impossible to determine the average number of vessels per patient.

 

Heart Transplants

In 2000, 2,198 heart transplants were performed in the United States. Currently there are 260 transplant centers in the United States, 196 of which perform heart transplants.

• It’s estimated that each year thousands of Americans would benefit from a heart transplant.

• In the United States 73% of heart transplant patients are male, 77% are white, 19% are ages 35-49, and 51% are ages 50-64.

• 84% of patients survived 1 year, based on heart transplants performed from 1994 to May 2000. The 3-year survival rate was about 77%, and the 5-year survival rate was 69%.

 

Percutaneous Transluminal Coronary Angioplasty (PTCA)

• An estimated 601,000 PTCA procedures were performed in 1999 in the United States. From 1987 to 1999 the number of procedures increased 285% and the number of patients increased 286%.

• In 1999, 66% of PTCA procedures were performed on men; 48% were performed on people over age 65.

 

ECONOMIC COST of Cardiovascular Diseases

The cost of cardiovascular diseases and stroke in the United States in 2002 is estimated at $329.2 billion. This figure includes health expenditures (direct costs, which include the cost of physicians and other professionals, hospital and nursing home services, the cost of medications, home health care and other medical durables) and lost productivity resulting from morbidity and mortality (indirect costs). By comparison, in 2001 the estimated cost of all cancers was $156.7 billion ($56.4 billion in direct costs and $100.3 billion in indirect costs). In 1999 the estimated cost of HIV infections was $28.9 billion ($13.4 billion direct and $15.5 billion indirect).