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Endoscopic Band Ligation versus Argon Plasma Coagulation in Treatment of Gastric Antral Vascular Ectasia

Tarek El-Mahdy Korah, MD; Elsayed Ibrahim Elshayeb, MD; Mohamed Hamdy Badr, MD; Ezzat Mohamed Abdalla, M.B.B.CH

Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebeenelkom, Menoufia, Egypt

eabdalla89@yahoo.com

Abstract: Objective: To evaluate the therapeutic effects of endoscopic band ligation (EBL) as a modality for the treatment of bleeding from gastric antral vascular ectasia (GAVE) in comparison to argon plasma coagulation (APC) in Egyptian patients. Background: Argon Plasma Coagulation (APC) is considered the standard commonly used treatment for Gastric antral vascular ectasia (GAVE). Recently, the use of banding in the gastric antrum has been evaluated for the treatment of GAVE. Methods: The study was conducted on thirty patients presenting with bleeding from GAVE. The patients were divided into two groups: Group I (EBL) group: 15 patients were subjected to EBL. Group II (APC) group: 15 patients were subjected to APC. Sessions were done every 3 weeks till satisfactory endoscopic ablation was achieved. Regular endoscopic assessment at 3 months was done with documentation of the recurrence of GAVE if found. Results revealed that thirteen patients were males and seventeen were females with age ranging from 51-70 years old. Most of the patients presented with overt bleeding (hematemesis and/or melena) (67%) in the APC group and (67%) in the EBL group. In endoscopic band ligation group, all patients (100%) showed complete improvement with no upper gastrointestinal endoscopic recurrence. In APC 10 patients, (67%) showed complete improvement with no upper gastrointestinal endoscopic recurrence, 5 patients (33 %) showed no upper gastrointestinal endoscopic improvement. In conclusion, EBL is a better treatment modality for GAVE than APC.

[Tarek El-Mahdy Korah; Elsayed Ibrahim Elshayeb; Mohamed Hamdy Badr; Ezzat Mohamed Abdalla. Endoscopic Band Ligation versus Argon Plasma Coagulation in Treatment of Gastric Antral Vascular Ectasia. Stem Cell 2017;8(2):1-5]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 1. doi:10.7537/marsscj080217.01.

Key words: Argon Plasma Coagulation. Endoscopic Band Ligation. Gastric Antral Vascular Ectasia

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Impacts of residual renal function (RRF) on clinical and laboratory features of chronic hemodialysis patients

Heba Kamal Abd El Khalek¹, Prof. Said Sayed Ahmed Khamis¹, Dr. Hany Said Elbarbary¹, Dr. Mahmoud Mohamed Emara¹ and Dr. Ashraf Abd El-Raouf Dawood²

¹Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt.

²Biochemistry Department, Faculty of Medicine, Menoufia University, Egypt.

dr.hebakamal88@yahoo.com

Abstract: Objective: To study the effect of residual renal function (RRF) on clinical and laboratory features of chronic haemodialysis patients. Background: Residual renal function (RRF) in patients with end-stage renal disease (ESRD) is defined as the ability of native kidneys to eliminate water and uremic toxins. Studying the impacts on haemodialysis patients will guide nephrologist for better preservation of (RRF) and so improve outcome of their patients. Patients and Methods: The clinical and laboratory data of 73 regular haemodialysis patients(more than 3 months) of dialysis unit at our Department of Internal Medicine and during a 6 month period from October 2016 to March 2017 were reviewed in a retrospective manner the patients classified according to presence of (RRF) and not to two groups. Results: this study reveal that hypertension is the main cause of renal failure in both groups and show significant correlation between(RRF)(positive for group having residual function) and ultrafiltration rate, serum creatinine, serum potassium, haemoglobin level, serum iron, transferrin saturation, intact parathyroid hormone and CRP and no correlation between (RRF) and blood pressure, heart rate, body mass index, serum urea, serum sodium, calcium, phosphorus, uric acid, serum ferritin and serum albumin. Conclusion: residual renal function has clinical and laboratory effects on our patients of residual and provide them better survival than patients of non residual. Our study about (RRF) on dialysis patients confirms most of the findings of previous studies that clarify the importance of (RRF) on patients' survival and the importance of its preservation.

[Heba Kamal Abd El Khalek, Prof. Said Sayed Ahmed Khamis, Hany Said Elbarbary, Mahmoud Mohamed Emara and Ashraf Abd El-Raouf Dawood. Impacts of residual renal function (RRF) on clinical and laboratory features of chronic hemodialysis patients. Stem Cell 2017;8(2):6-12]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 2. doi:10.7537/marsscj080217.02.

Key Words: Residual Renal Function - chronic hemodialysis.

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Adipnectin level in gastroesophageal reflux disease

Ibrahim M. Boghdady¹, Elsayed I. Elshayeb¹, Mona Salah El-dinHabib ², and Tamer Ibrahim abduelrahman¹

¹Department of Internal Medicine and gastroenterology, Faculty of Medicine, Menoufia University, Egypt

²Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Egypt

Tamer_abrahim@yahoo.com

Abstract: Objectives: to evaluate serum adiponectin in gastro-oesophageal reflux patients and its correlation with obesity. Background: Gastroesophageal reflux disease (GERD) is a common disorder, it develops when the gastric content pass to the esophagus which prompt disability of personal satisfaction. Several factors may predispose to reflux including smoking, alcohol, drugs and large night meals. Obesity is known to be an independent risk factor for GERD through Decrease tone of lower esophageal sphincter. Abdominal obesity not only mechanically disrupts the integrity of the gastro-esophageal junction barrier which leads to increased esophageal reflux but also has a metabolically mediated effect through secretion of adipocytokines. Methods: A case-control study was performed between October 2014 to January 2016 in Internal Medicine department; Menofia University Hospital. One hundred subjects were included in this study and classified into 3 groups: Group (І) included twenty healthy individuals with average BMI serve as a control group. Group (ІІ) included forty obese patients with GERD symptoms confirmed by upper endoscopy with BMI >24kg. Group (ІІІ) included forty non-obese patients with GERD symptoms confirmed by upper endoscopy. Clinical factor and laboratory investigation were compared between subjects with and without GERD as well as serum adiponectin measurement by ELIZA for all groups. Results: Serum adiponectin levels were significantly lower in obese patients with GERD and in non-obese patients with GERD compared to those in healthy control (P<0.001). Low level of circulating adiponectin was associated with Barrett’s esophagus. Receiver operating characteristic curve showed that the best cutoff value for serum adiponectin was 7.67 (μg/ml) with a sensitivity of 95% and specificity of 94%. Conclusions: Low serum adiponectin levels may be associated with an increased risk for GERD in obese patients.

[Ibrahim M. Boghdady, Elsayed I. Elshayeb, Mona Salah El-din Habib, and Tamer Ibrahim abduelrahman. Adipnectin level in gastroesophageal reflux disease. Stem Cell 2017;8(2):13-18]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 3. doi:10.7537/marsscj080217.03.

Keywords: Adiponectin. Gastro-esophageal reflux disease. Obesity

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Correlation between Interleukin 22 Serum Level and Severity of Psoriasis

Reham Mohammad Gamal Dewidar¹, Shawky Mahmoud EL Farargy¹ and Naglaa Mohammad Ghanayem²

¹Dermatology and Andrology Department, Faculty of Medicine, Menoufia University, Shebeenelkom, Menoufia, Egypt

² Biochemistry Department, Faculty of Medicine, Menoufia University, Shebeenelkom, Menoufia, Egypt

Sameh_khoud2003@yahoo.com

Abstract: Objectives: to study the Correlation between Interleukin 22 serum Level and severity index of Psoriasis Background: Interleukin-22 is a member of the IL10 cytokine family, described as having proinflammatory activites on liver, pancreas, intestine and skin. Material and Methods: The study was don on 45 subjects. These included 30 cases with chronic plaque psoriasis & 15 age- and sex-matched healthy individuals. All Patients were subjected to history taking and complete medical examination. Serum levels of IL-22 were measured by ELISA technique. Serum levels of IL-22 were statistically analyzed in relation to psoriasis area and severity index (PASI). Results: The serum levels of IL-22 was highly elevated in psoriasis patients compared with healthy people The serum IL-22 was significantly higher in patients with severe psoriasis as compared with those with mild and moderate psoriasis. The serum levels of IL-22 was higher in patients with long duration of psoriasis compared with recent psoriatic patients. Conclusion: IL-22 is involved in psoriasis. There is significant positive correlation between IL-22 serum levels and each of duration of psoriasis and PASI.

[Reham Mohammad Gamal Dewidar, Shawky Mahmoud EL Farargy and Naglaa Mohammad Ghanayem. Correlation between Interleukin 22 Serum Level and Severity of Psoriasis. Stem Cell 2017;8(2):19-24]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 4. doi:10.7537/marsscj080217.04.

Keywords: cytokins, inflammation, Psoriasis, skin disease

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Role of laparoscopy in the management of abdominal trauma

Ashraf Abd Elhady, MD, Ahmed Gaber, MD, Mohamed Abd El-khalek, M.B.BCH

General surgery department, Faculty of medicine, Menoufia University.

drmohammedabdelkhalek85@yahoo.com

Abstract: Objective: The aim of the work is to study the feasibility, the advantages and the disadvantages of laparoscopy in diagnosis and treatment of abdominal trauma. Background: The role of laparoscopy in diagnosis and treatment of abdominal trauma has increased markedly in the last few years. Since the use of laparoscopy in diagnosis and management of abdominal trauma the number of negative and/ or nontherapeutic laparotomies performed has decreased. Patients and methods: Thirty patients with abdominal trauma 11 blunt traumas (BT), 19 penetrating trauma (PT) were treated by the Trauma Team at the Emergency Units of Menofyia University and Maadi Military Hospital from January 2014 to May 2016 using laparoscopy for diagnosis. All patients underwent a physical examination, Ultrasound, and computed tomography (abdomen and pelvis). Laparoscopy was used in the management of these patients through three trocars: one for 30° scope and two working trocars. Results: In our series, we avoided laparotomy in 66.6% (20/30) of cases. Negative and non-therapeutic laparoscopies four patients and therapeutic laparoscopy was performed in ten patients; six patients hand assisted splenectomy, three patients need repair of liver tears, three patients need diaphragmatic tear repair, six patients need primary repair for bowel and two patients need stomach repair. Conclusion: Laparoscopy can be performed in management of stable patients with abdominal trauma safely and effectively.

[Ashraf Abd Elhady, Ahmed Gaber, Mohamed Abd El-khalek. Role of laparoscopy in the management of abdominal trauma. Stem Cell 2017;8(2):25-30]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 5. doi:10.7537/marsscj080217.05.

Keywords: Abdominal trauma, laparoscopy, penetrating injury, blunt injury.

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Effect of Planting Date on Different Parts of the Root Yield Corn Silage

Iraj Amiri¹, Somaye Kheyri², Mohammad Reza Shahrokhi Sardo³, Saeed Shojaei^1,*

¹Department of Management the Arid and Desert Regions, Yazd University, Iran

²Master of Water Resources Engineer, Ardestan Branch, Islamic Azad University, Ardestan, Iran

³Master of Water Resources Engineer, Kerman Branch, Islamic Azad University, Kerman, Iran

E-mail: s_shojaei@ut.ac.ir

Abstract: Man with all the progress made in agriculture is still suffered the problem of food poverty in some parts of the world. The aim of this research was to investigate the effect of planting date on the root yield Corn Silage because with increase parts underground of sections air will be more growth. This research on three planting dates May 19, 17 June and 22 July as main factor levels and the size of the root at the time of transfer along with a seed direct seeding treated as a witness as sub factor for the design of a split plot done in format of blocks design randomized complete with four replications. Results showed that between planting date treatments, there is a significant difference in root yield per hectare. May 19 planting date mentioned in terms of traits with production of root yield is showed superiority equivalent to 77/66 tons per ha.

[Amiri I, Kheyri S, Shahrokhi Sardo MR, Shojaei S. Effect of Planting Date on Different Parts of the Root Yield Corn Silage. Stem Cell 2017;8(2):31-34]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 6. doi:10.7537/marsscj080217.06.

Keywords: Planting Date, Size Radicle, Corn Silage, Growth.

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Evaluation of the Accuracy of Some of Geostatistical Methods

Sadegh Zohrabi¹, Saeed Shojaei^2,*, Marjan Talebiniya¹

¹M.S. student of Combating Desertification, Faculty of Natural Resources, University of Tehran

^2*Ph.D. Student Department of Management the Arid and Desert Regions, Yazd University, Iran

s_shojaei@ut.ac.ir

Abstract: Desertification has been one of the major worldwide problems in recent decades. This factor reduces soil potential and thus decreases the biomass. Desertification has various factors; soil salinity is one of these factors. Determination of soil salinity changes is very important in the world because the amount and intensity of desert development can be investigated by studying the salinity changes. The geostatistical methods are among the studied methods in order to prepare soil salinity map. In this study, preparing the salinity map was carried out by taking the random samples from the region. To proper sampling of studied area, at the first 150 count have been read state by using electromsgnetic inductor device. The studied geostatistical methods were: Cokriging, Regression Kriging, Kriging and Inverse Distance Weighted. According to the obtained results, the lowest error rate was observed in Regression Kriging and it was more accurate than the other models.

[Zohrabi S, Shojaei S, Talebiniya M. Evaluation of the Accuracy of Some of Geostatistical Methods. Stem Cell 2017;8(2):35-39]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 7. doi:10.7537/marsscj080217.07.

Keyword: Inverse Distance Weighted, Cokriging, Regression Kriging, Kriging, desertification

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Evaluation of the Accuracy of Regression Kriging and Cokriging Models to Determine Soil Salinity

Saeed Shojaei¹, Hadi Siasar^2,*

¹Ph.D. Student Department of Management the Arid and Desert Regions, Yazd University, Iran

²Department of Agriculture, Payame Noor University, Iran

E-mail: hadisiasar@pnu.ac.ir

Abstract: Desertification phenomenon and loss of land potential are caused by one or a combination of desertification processes such as, salinization of land, destruction of plant resources, waterlogging, water erosion, wind erosion and etc that intensify by natural and human factors. The purpose of this study is to evaluate changes in soil salinity using geostatistical methods. The research was carried out in Ardakan region to assess soil salinity (electrical conductivity) using geostatistical techniques (Regression Kriging model and Cokriging model). 150 points were taken to determine the amount of electrical conductivity by electromagnetic inductor device. The results showed that the northern parts have less salinity and the southern parts have more salinity. According to the results, the Regression Kriging method is more accurate than the Cokriging model.

[Shojaei S, Siasar H. Evaluation of the Accuracy of Regression Kriging and Cokriging Models to Determine Soil Salinity. Stem Cell 2017;8(2):40-44]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 8. doi:10.7537/marsscj080217.08.

Keywords: Model, Soil Salinity, Regression Kriging, Cokriging

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The Outcome of Surgical Management of Solitary Spinal Metastasis

Adel Mahmoud Hanafy (MD)¹, Nehad Abdo Zeid (MD)², Haitham El Beltagy Abd El-Kader (MD)¹, Mohamed Morsy Al Mashd (MD)¹, Mohamed Mahmoud Abo-Hussein (M.B.B.Ch)¹

¹ Neurosurgery Department, Faculty of Medicine, Menoufia University, Egypt

² General Surgery Department, Faculty of Medicine, Menoufia University, Egypt

futuredoctor20132001@yahoo.com

Abstract: Spinal metastasis is common among cancer patients and it has great influence on their quality of life. It causes intractable pain, in addition to motor dysfunction. Surgery is an old widely acceptable treatment for solitary spinal lesions. It may serve as a palliative treatment as it helps to relieve pain, preserve or restore the neurological function. This study is to evaluate the effect of different surgical modalities on the improvement of the clinical status of patients with solitary spinal metastasis. We made a prospective study on 18 patients admitted to our neurosurgery department. Preoperatively, neurological status and pain were evaluated by the JOA scale, Frankel grade and VAS. MRI spine with contrast was done, and cord compression was assessed by ESCC scale. All patients were evaluated by Tokuhashi scoring system. Anterior approach was used in two patients, and Posterior approach was used in 16 patients with several surgical modalities. All the patients received post-operative radiotherapy and underwent follow up for 6 months. There is a significant statistical difference between pre and post-operative VAS and Frankel grade with (p-value=0.003) and (p-value=0.013) respectively. There is a significant correlation between pre-operative neurological status and the outcome. A strong factor influencing post-operative improvement of the patients was pre-operative neurological condition in this study.

[Adel Mahmoud Hanafy, Nehad Abdo Zeid, Haitham El Beltagy Abd El-Kader, Mohamed Morsy Al Mashd, Mohamed Mahmoud Abo-Hussein. The Outcome of Surgical Management Of Solitary Spinal Metastasis. Stem Cell 2017;8(2):45-52]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 9. doi:10.7537/marsscj080217.09.

Keywords: spinal metastases; Surgery; Solitary; Outcome

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Endothelial Cells Heterogeneity

Sabry Abdallah Shoeib, Mohammed Ahmed Abd El-Hafez, Alaa Effat Abd El-Hamid and Safwat Abd El-Halim Mahmoud

Department of Internal Medicine, Faculty of Medicine, Menofyia University, Egypt

drsafwat16@yahoo.com

Abstract: The vascular endothelium constitutes approximately 1% of body mass (1kg) and has a surface area of approximately 5000m (2). The endothelium is a multifunctional endocrine organ strategically placed between the vessel wall and the circulating blood, and has a key role in vascular homeostasis. The endothelium forms the inner cellular lining of blood vessels. It is now well established that endothelial cells are highly metabolically active, and play a critical role in many physiological processes, including the control of vasomotor tone, the trafficking of blood cells between blood and underlying tissue, the maintenance of blood fluidity, permeability, angiogenesis, and both innate and adaptive immunity. It is also recognized that the endothelium is involved in most if not all disease states, either as a primary determinant of pathophysiology or as a victim of collateral damage. This study highlights the molecular and the physiological aspects of endothelial cells heterogeneity and its clinical implications.

[Sabry Abdallah Shoeib, Mohammed Ahmed Abd El-Hafez, Alaa Effat Abd El-Hamid and Safwat Abd El-Halim Mahmoud. Endothelial Cells Heterogeneity. Stem Cell 2017;8(2):53-58]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 10. doi:10.7537/marsscj080217.10.

Keywords: vascular endothelium; surface area; multifunction; endocrine; organ; blood; vascular homeostasis; immunity; pathophysiology; victim; clinical implication

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Acute Coronary Syndrome Registries

Hala Mahfouz Badran¹; Ahmed Magdy kamal Eldin²; Ghada Mahmoud Sultan¹; Mohamed Osama Said El-Alem¹

¹Cardiology Department, Faculty of Medicine-Menoufia University, Egypt

²National Heart Institute, Egypt

Drelalem@yahoo.com

Abstract: Objective: Coronary heart disease is the most common cause of death in the US and Europe.^(1,2) ACS, a common complication of coronary heart disease, is associated with more than 2.5 million hospitalizations worldwide each year ⁽³⁾. This review provides a contemporary overview of key new findings on the pathophysiology, diagnosis, treatment, prognosis of ACS, ACS registries, its importance and discussing most famous and well established registries. Data Sources: medical text books, medical journals, and medical websites that have updated researches with key words (Acute Coronary Syndrome) in the title of the paper. Study Selection: systematic reviews that addressed Acute Coronary Syndrome and studies that addressed Acute Coronary Syndrome Registries. Data Extraction: a special search was conducted at midline with the key words Acute Coronary Syndrome in the title of the paper; extraction was performed, including the assessment of the quality and the validity of the papers that met with the prior criteria that describe the review. Data Synthesis: the main result of the review. Each study was reviewed independently; the data obtained were rebuilt in a new language according to the need of the researcher and arranged into topics through the article.

Recent Findings:

·       The diagnosis, management and treatment of the various forms of acute coronary syndromes (ACS) which include ST- segment elevation myocardial infarction (STEMI), non-ST- segment elevation (non-STEMI), and unstable angina (UA) have been rapidly evolving in recent years.

·       Surveys and registries are an effective meaning of assessing the implementation of guidelines. Although the adherence to guidelines has been shown to be associated with improved outcomes, their implementation remains sub-optimal.

·       Smoking, Hypertension, and diabetes are most common risk factors, which didn‘t change over years. This finding necessitates the formulation of programs for primary and secondary prevention of coronary artery disease.

·       Evidence based therapies were widely used unless contra- indicated.

·       The intervention strategies have seen some flourishment. The percentage of PCI increased significantly, but still thrombolysis is the primary reperfusion modality. That shows the need for developing our insurance system to cover a broader spectrum with more services.

·       In hospital complication has decreased significantly.

·       Mortality has decreased significantly due to the increase in the use of Primary PCI.

Conclusions: ACS is a potentially life-threatening condition that affects millions of individuals each year. Despite declining rates of hospitalization for MI, the identification and prevention of ACS continues to be an important public health concern. Over the past several years, studies have led to an improved understanding of the pathophysiology of ACS and advancements have been made in the medical management of this condition. Initial ACS management should include risk stratification, appropriate pharmacologic management including DAPT, anticoagulation and appropriate adjuvant therapies, and a decision to pursue an early invasive or conventional treatment strategy. Long-term management following an ACS event should follow evidence-based recommendations and should be individualized to each patient. Observational studies have revealed large differences in the clinical management of patients with cardiovascular diseases when comparing different regions within a country, different countries in specific regions, or different regions across the globe. Because these studies were conducted predominantly in developed countries, there is a need to establish registries in developing countries to increase awareness of cardiovascular disease burden and establish appropriate preventive and management strategies.

[Hala Mahfouz Badran; Ahmed Magdy kamal Eldin; Ghada Mahmoud Sultan; Mohamed Osama Said El-Alem Acute Coronary Syndrome Registries. Stem Cell 2017;8(2):59-70]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 11. doi:10.7537/marsscj080217.11.

Key words: Acute Coronary Syndrome, Registries

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Evaluation of Topical Potassium Hydroxide Solution for Treatment of Plane Warts

Hala E. Rezk and Mohamed Abd-Elwahed Gaber

Dermatology and Andrology Department, Faculty of Medicine, Menoufia University, Egypt

Halabkhr@gmail.com

Abstract: Objective: Evaluate the efficacy and tolerability of topical KOH solution in the treatment of plane wart. Background: Plane wart is a common dermatological disease that is caused by human papilloma virus; although the rate of spontaneous recovery is high, it usually takes a long time to occur. Many modalities of treatments have been used but none of them proved to be uniformly effective. Potassium hydroxide (KOH) solution is a well-known keratolytic agent with many dermatological uses. Materials and Methods: A total of 100 patients with plane warts, were enrolled in this opened therapeutic trial study. Patients were divided into two age and sex cross-matched equal groups; patients in group (A) were treated with topical 10% KOH solution once at night, while patients in group (B) were treated with topical 15% KOH solution once nightly. Only 42 patients from group (A) and 40 patients from group (B) completed the study, while the remainders were defaulted for unknown reasons. The patients were evaluated at second and fourth week to assess the cure rates and side effects, those patients who showed complete cure were followed up for 3 months to detect any recurrence. Results: At the end of second week, 66.7% of group (A) patients showed complete disappearance of their warts, vs 75% of group (B) patients. At the end of fourth week, 81% of group (A) patients showed complete response in comparison with 87.5% of group (B) patients. The side effects for the treating solution in both concentrations include itching, burning sensation, erythema, and temporary dyspigmentations, that were reported in 73.8% of group (A) patients in comparison with 90.5% of group (B) patients. Recurrence rate was reported in 11.9% of group (A) patients vs 5% of group (B) patients during the three months period of follow up. Conclusions: Topical KOH solution is proved to be an effective and safe treatment of plane warts in both concentrations (10% and 15%) with no important side effects.

[Hala E. Rezk and Mohamed Abd-Elwahed Gaber. Evaluation of Topical Potassium Hydroxide Solution for Treatment of Plane Warts. Stem Cell 2017;8(2):71-75]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 12. doi:10.7537/marsscj080217.12.

Keywords: Plane warts, potassium hydroxide, keratolytic agent

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Microparticles in Hematology: From biology to diagnostics and therapeutics

Abd Elfattah Mohammed Hamed; Sabry Abdallah Shoeib; Mohammed Ahmed Abd Elhafez; Alaa Efat Abd Elhamid

Internal Medicine department, Department, Faculty of Medicine, Menoufia University, Egypt

Toha_h2000@yahoo.com

Abstract: The present work was designed to review the literature about microparticles and their role in hematology. We found that, cell-derived microparticles had an essential role in hemostatic response and their potential as disease markers, but also their implication in a wide range of physiological and pathological processes. Microparticles derive from different cell types including platelets – the main source of microparticles – but also from red blood cells, leukocytes and endothelial cells, and they circulate in blood. In hematology, their earliest recognized and most widely accepted role is the ability to promote and support the process of blood coagulation. Consequently, there is ongoing interest in studying MPs in disorders of hemostasis and thrombosis. Both phosphatidylserine (PS) exposure and the presence of tissue factor (TF) in the MP membrane may account for their procoagulant properties, and elevated numbers of MPs in plasma have been reported in numerous prothrombotic conditions. Conclusion: microparticles could play an important role in the field of health and disease, especially in the field of hematology. However, it is advisable to construct future studies for examination of microparticles role in different disease states.

[Abd Elfattah Mohammed Hamed; Sabry Abdallah Shoeib; Mohammed Ahmed Abd Elhafez; Alaa Efat Abd Elhamid. Microparticles in Hematology: From biology to diagnostics and therapeutics. Stem Cell 2017;8(2):76-84]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 13. doi:10.7537/marsscj080217.13.

Keywords: Microparticles, hematology, coagulation, thrombosis, biomarker

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Monoclonal gammopathy of renal significance

Hany Shaker Ali Mohamad; Sabry Abd-Allah Mohamad Shoaib; Mohamad Ahmad Mohamad Abd El-Hafez

Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt

dr_hany2004@yahoo.com

Abstract: Background: monoclonal gammopathy is an immune disease with immune-globulin or part of it is produced by clonal propagation of cells in B-lymphocytes. Its role in renal disease is recently studied. However, the field had many gaps in the understanding of the disease. Aim of the work: to study the role of monoclonal gammopathy of renal importance. Methods: an internet based search during the last 20 years with a keyword search of monoclonal gammopathy in the title of papers was done. Studies with sufficient data about the topic were thoroughly reviewed and the important results were included in the present work. Results: monoclonal immunoglobulins were found to have the ability to lead to different renal disorders resulting from the direct renal deposition of the monoclonal imuunoglobulin (MIg), and rarely from an indirect mechanism via dysregulation of the alternative pathway of complement. Conclusion: The monoclonal gammopathy-associated renal diseases are distinct in their pathogenesis, kidney biopsy findings, clinical presentation, progression, prognosis, and treatment. A thorough and complete evaluation of the MIg-associated renal disease needs to be performed to appropriately.

[Hany Shaker Ali Mohamad; Sabry Abd-Allah Mohamad Shoaib; Mohamad Ahmad Mohamad Abd El-Hafez Monoclonal gammopathy of renal significance. Stem Cell 2017;8(2):85-94]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 14. doi:10.7537/marsscj080217.14.

Keywords: monoclonal; gammopathy; renal insufficiency; renal transplantation; immunoglobulins

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Evaluation of Oral and Parenteral Iron Treatment Preparations in Pregnant Women with Iron Deficiency Anemia

Ahmed Nabil Abdelhameed, MD¹, Tarek Mohammad Sayyed, MD¹, Hesham Ali Ammar, MD¹ and Karema El Sayed Abdelhameed M.B.B.CH²

¹Obstetrics & Gynecology Department, Faculty of Medicine - Menoufia University, Egypt

² Obstetrics & Gynecology Department, Quesna Emergency Hospital, Egypt

yomnamordy@gmail.com

Abstract: Objectives: to evaluate efficacy and safety of oral and parenteral iron preparations in pregnant women with iron deficiency anemia. Subjects and Methods: this clinical trial completed Between August 2015 and December 2016, at Department of Obstetrics and Gynecology in Quesna Emergency Hospital in the wake of acquiring an endorsement of its institutional board audit. The review members are 121 pregnant ladies (mean age 25.5 years; extend 20 to 40 years), (mean GA 24 weeks; rang 16 to 28 weeks) who go to the obstetric outpatient facility for antenatal care with the conclusion of iron inadequacy Anemia. Results: From the results it can be concluded that parenteral iron more powerful than oral iron and the term of treatment was less in parenteral group. In our study oral iron preparation demonstrates a similar outcome toward the finish of the review however iron poly maltose complex shows more GIT up sets more than ferrous sulfate. Parenteral iron poly maltose complex shows huge augmentation in Hb, serum iron and serum ferritin yet this outcome switched toward the finish of the study and iron sucrose turn out to be more powerful. From the results it can be concluded that parenteral iron more powerful than oral iron and the term of treatment was less in parenteral group. Conclusion: From the results it can be concluded that parenteral iron treatment was better endured with higher increment in mean hemoglobin when contrasted with oral iron treatment. There were no genuine reactions with parentraliorn therapy. Parentraliorn therapy is a good substitute to oral iron therapy in moderate to severe anemia.

[Ahmed Nabil Abdelhameed, Tarek Mohammad Sayyed, Hesham Ali Ammar and Karema El Sayed Abdelhameed. Evaluation of Oral and Parenteral Iron Treatment Preparations in Pregnant Women with Iron Deficiency Anemia. Stem Cell 2017;8(2):95-100]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 15. doi:10.7537/marsscj080217.15.

Keywords: Maternal anemia, Iron supplementation, Oral iron, Parenteral iron

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Comparison between shock index and lactate as prognostic markers in severe sepsis and septic shock in PICU

Fady M Elgendy, Nagwan Y saleh, Mohammed A Aboukoura

Department of pediatrics, Faculty of medicine Menufia University, Egypt

kouramohd@gmail.com

Abstract: Objectives: to compare shock index with lactate as prognostic markers of mortality in pediatric with severe sepsis and septic shock. Background: shock index is calculated from HR and SBP as vital sign and follow up of the septic patient by an easy bedside test as shock index which can affect the outcome. Material and Methods: This is an analytical study done at the pediatric intensive care unit (PICU) of Menoufia university Hospital from Jan 2015 to Dec 2016. We studied 50 patients who met the inclusion criteria by assessment of shock index in 0,6,12 and 24 hours from admission with measurement of lactate in same points. Patients under the study were divided into two groups according to outcome: survivors and non survivors. Results: As regarding shock index in our population under the study, the mean of shock index improved in survivors than non survivors after 12 and 24 hours with statistical significance of 0.04 and 0.05 respectively that not observed in HR and SBP alones. These improvement associated with normalization of lactate after 12 hours (<18 mg/dl) hours which is highly significant with p value of (<0.01) and highly correlated to PRISM score. Conclusion: Shock index is easily calculated and its improvement is prognostic and associated with low mortality.

[Fady M Elgendy, Nagwan Y saleh, Mohammed A Aboukoura. Comparison between shock index and lactate as prognostic markers in severe sepsis and septic shock in PICU. Stem Cell 2017;8(2):101-105]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 16. doi:10.7537/marsscj080217.16.

Keywords: lactate, prognostic value, severe sepsis, septic shock, shock index

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Non-alcoholic fatty liver disease (NAFLD): An Immunologist's Perspective

Sherif Awad El Sheshtawy; Sabry Abdallah Shoeib; Alaa Efat Abd Elhamid; Emad Mohammad El-Shebini

Internal Medicine, Faculty of Medicine, Menofiya University, Egypt

Sherifawad16@gmail.com

Abstract: The present work was designed to review the literature about immunopathogenesis of Nonalcoholic Fatty Liver Disease. We found that, NAFLD constitutes one of the three major causes of cirrhosis and liver transplantation, given the possible evolutive course of this disease, and can also be associated with the occurrence of a hepatocellular carcinoma. Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen- associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern- recognition receptors that result in inflammation. Conclusion: The pathogenesis of NAFLD is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose tissue. Obesity is considered a chronic low-grade inflammatory state and the liver has been recognized as being an “immunological organ”. The complex role of the immune system in the pathogenesis of NAFLD is currently raising great interest, also in view of the possible therapeutic potential of immunotherapy in NAFLD.

[Sherif Awad El Sheshtawy; Sabry Abdallah Shoeib; Alaa Efat Abd Elhamid; Emad Mohammad El-Shebini. Non-alcoholic fatty liver disease (NAFLD): An Immunologist's Perspective. Stem Cell 2017;8(2):106-116]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 17. doi:10.7537/marsscj080217.17.

Keywords: NAFLD, NASH, liver cirrhosis, HCC, adipose tissue, innate immunity, cellular players, adaptive immunity.

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Early Versus Late Intervention in High Risk Patients with Non ST Elevation Myocardial Infarction

Mahmoud Abd El-Aal Mahmoud M.B.B.CH¹, Ahmad Mohamed Emara MD², Ahmad Magdy Mohamed MD¹ and Neveen Ibrahim Samy MD²

¹National Heart Institute, Cairo, Egypt

² Cardiology Department, Faculty of Medicine, Menoufya University, Menoufya, Egypt

Mahmoud_all_85@yahoo.com

Abstract: In this review we investigate the outcome of early vs. late intervention high-risk patients with non-ST-elevation acute coronary syndromes.

[Mahmoud Abd El-Aal Mahmoud, Ahmad Mohamed Emara, Ahmad Magdy Mohamed and Neveen Ibrahim Samy. Early Versus Late Intervention in High Risk Patients with Non ST Elevation Myocardial Infarction. Stem Cell 2017;8(2):117-120]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 18. doi:10.7537/marsscj080217.18.

Keywords: Early Intervention; Late Intervention; High Risk Patient; Elevation; Myocardial Infarction

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The Effect of Diabetes Mellitus Control on Subclinical Inflammation in Type 2 Diabetes Mellitus

Walid Abd El Mohsen Shehab Eldin MD¹, Mohamed Zakarya Nouh MD¹, Azza Mohamed Kamel Abdallah MD², and Dina Abd El-Basset Shokr M.B., B.Ch³.

¹ Department of Internal Medicine, Faculty of Medicine-Menoufia University, Egypt.

²Department of Biochemistry, Faculty of Medicine-Menoufia University. Egypt.

³ Department of Internal Medicine, Ministry of Health, Egypt.

dinaabdelbaset33@gmail.com

Abstract: Purposeful: To study the state of subclinical inflammation in patients with type 2 diabetes mellitus. Moreover, to study the relation, if any, between glycemic control and inflammation. Background: Subclinical inflammation and presence of almost all indicators of systemic inflammation are found in type 2 diabetic patients. Such a systemic and subclinical inflammatory process can be characterized by elevated circulating levels of inflammatory markers. Methods: This research included 90 subjects divided into 2 groups; Group A: 70 patients with type 2 diabetes at the time of presentation and Group B: 20 Age and sex matched people as the control group. After providing written informed consent, all patients were clinically examined, had laboratory investigations including; fasting and 2 hours postprandial blood sugar, HbA1c, serum ferritin., high sensitivity C-reactive protein, kidney functions tests, liver function tests, complete blood count and erythrocyte sedimentation rate and antinuclear antibody. Results: Regarding laboratory investigations there was significant difference between the two group regarding revealed that diabetic patients had higher values of; ESR, Hs-CRP and serum frritin. Correlation study revealed significant positive correlation between HbA1c and (Hs-CRP and serum frritin). Summary: Our findings suggest that there is augmented inflammation in T2DM patients manifested by elevated ESR, serum ferrtin and hs-CRP. Also, we found significant positive correlation between HbA1c and (Hs-CRP and serum ferritin). All these finding suggesting a link between inflammation and glycemic control in patient with type 2 diabetes mellitus.

[Walid Abd El Mohsen Shehab Eldin, Mohamed Zakarya Nouh, Azza Mohamed Kamel Abdallah, and Dina Abd El-Basset Shokr. The Effect of Diabetes Mellitus Control on Subclinical Inflammation in Type 2 Diabetes Mellitus. Stem Cell 2017;8(2):121-125]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 19. doi:10.7537/marsscj080217.19.

Key words: Diabetes mellitus, Subclinical inflammation.

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