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太 极 话 天 下

孙纯武

孙纯武 (1948年-)，男 (汉族)，中国江苏省扬州市，主要从事研究自然科学等

单位名称、江苏省扬州三力电器集团有限公司退休工人 邮编225008

电子信箱： yzscw0514@163.com, 微信号 scw20171020

Abstract: 太极话天下书是破译东方神秘主义太极八卦图的科学原理，以浅显的文化,集寓教于乐贯穿始终，专门为广大青少年和科研爱好者及发明家们，定制打造当今科学世界更令人惊叹的新哲学和动态场的物理学新知识，让你通过本书阅读，对宇宙对世间从无到有、从有到无等许多重大世界难题，用最少的时间得最多的新科学知识来充实自已、解放自已，做一个能力超群的万事通。如先了解宇宙的创生、地球山脉、水的产生，植物、动物及人的生老病死等许多重大世界难题。男女青年学会掌握书中实用的知识，使人生和来生更幸福地生活。有志气创业者从书中得到创业经验走向成功和发大财。患有各种疑难慢性病特别癌病、白血病、艾滋病、強直脊柱炎等患者提供了病的起因和治好病的经验及长寿方法。更是科学家们众里寻她千百度，从书中可得到新科学知识的启蒙，彻底从旧物理学中解放出来，创造出更完整的系统框架结构动态场新哲学和新物理学，来取得个人科研和学术上的重大成功。也不乏适合各种人群消逝时光品读的科普娛乐书。

[孙纯武. 太 极 话 天 下. Academ Arena 2021;13(4):1-36]. ISSN 1553-992X (print); ISSN 2158-771X (online). http://www.sciencepub.net/academia. 1. doi:10.7537/marsaaj130421.01.

Keywords: 太极、天下、东方神秘主义、八卦、科学、原理、文化、宇宙、物理学

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Calotropin a potent bioactive from milk of Calotropis gigantean against 2019-N-Cov M^pro/3CL^pro and Spike Protein

Arun Dev Sharma* and Inderjeet Kaur

Post Graduate department of Biotechnology, Lyallpur Khalsa College Jalandhar

*Arundevsharma47@gmail.com

Abstract: SARS-CoV-2 (COVID-19), a positive sense ssRNA virus, adherent of family of “corona” virus, is disseminating its appendages worldwide because of paucity of drugs at the moment. Due to its vital role in virus replication, M^pro and Spike (S) proteins have currently been considered as an appropriate target for designing of drug. The current study focused on the inhibitory activity of calotropin, a component of milk extracted from Calotropis gigantean, against M^pro and Spike proteins from SARS-CoV-2. So far, there is no work commenced on in-silico study of this compound against M^pro and Spike proteins of SARS-CoV-2. In the current analysis, we had used  Patchdock analysis to study molecular docking. Protein Interactions Calculator was practiced to analyze interactions among proteins. In-silico Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) profile was also studied. Docking score specified actual binding of component calotropin towards COVID 19 M^pro and S-protein. Interactions consequences specified that, M^pro and S-protein protein/calotropin complexes involve in interactions (hydrogen and hydrophobic). Besides, our analysis also threw light on the significant outcome that the S2domains of COVID 19 “S” glycoproteins possibly make interaction with calotropin. In silico ADMET analysis provided guidelines and possibility for identification of effective anti COVID 19 drug. Consequently, calotropin could signify probable herbal therapy to be used as inhibitor of COVID 19. Though, additional research is obligatory to explore their probable therapeutic use.

[Arun Dev Sharma* and Inderjeet Kaur Calotropin a potent bioactive from milk of Calotropis gigantean against 2019-N-Cov M^pro/3CL^pro and Spike Protein Academ Arena 2021;13(4):37-43]. ISSN 1553-992X (print); ISSN 2158-771X(online).http://www.sciencepub.net/academia.2. doi:10.7537/marsaaj130421.02.

Key words: COVID19; Docking; calotropin; Herbal Drug

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基因与外基因形式本体论之程

叶眺新（四川绵阳，621000）

Recommended: 王德奎 (Wang Dekui), 绵阳日报社, 绵阳, 四川 621000, 中国, y-tx@163.com

摘要：基因与外基因形式本体论之程说明，数理形式本体论的标准模型并不是不允许批评，恰恰是在众多的批评与完善中巩固起来的。

[叶眺新基因与外基因形式本体论之程Academ Arena 2021;13(4):44-48]. ISSN 1553-992X (print); ISSN 2158-771X(online).http://www.sciencepub.net/academia.3. doi:10.7537/marsaaj130421.03.

关键词：基因、外基因、形式本体论、拓扑学

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庞加莱猜想与不确定性原理刍议

----质量超弦时间之箭初探（1）

叶眺新（四川绵阳，621000）

Recommended: 王德奎 (Wang Dekui), 绵阳日报社, 绵阳, 四川 621000, 中国, y-tx@163.com

摘要：中微子相互作用的本真态和质量本真态相联系的映射矩阵与中微子的质量矩阵之间，建立的非常确定的波粒二象性，联系从宏观到微观物理学双缝实验的判据，这涉及庞加莱猜想与不确定性原理等价问题。如果不把李政道先生的物理和丘成桐先生的数学两大优势，在他们有生之年尽快地结合起来，我们将错失良机。

[叶眺新 庞加莱猜想与不确定性原理刍议----质量超弦时间之箭初探（1）Academ Arena 2021;13(4):49-57]. ISSN1553-992X(print);ISSN2158-771X(online). http://www.sciencepub.net/academia. 4. doi:10.7537/marsaaj130421.04.

关键词：双缝实验、庞加莱猜想、质量、不确定性

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量子瞬逝波及幻方的庞加莱猜想延伸

----质量超弦时间之箭初探（2）

叶眺新（四川绵阳，621000）

Recommended: 王德奎 (Wang Dekui), 绵阳日报社, 绵阳, 四川 621000, 中国, y-tx@163.com

摘要：在普朗克尺度的数量级范围内，关于量子粒子隧道效应1至9个“绕数”的幻方或纵横图研究，可以联系到远在公元前21世纪夏禹治水时及当代的科学应用。

[叶眺新 量子瞬逝波及幻方的庞加莱猜想延伸----质量超弦时间之箭初探（2）Academ Arena 2021;13(4):58-64]. ISSN1553-992X(print);ISSN2158-771X(online).http://www.sciencepub.net/academia. 5. doi:10.7537/marsaaj130421.05.

关键词：瞬逝波、幻方、魔环、庞加莱猜想、转座子，科学

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统一超弦和三旋的膜理论

王德奎 (Wang Dekui)

绵阳日报社, 绵阳, 四川 621000, 中国, y-tx@163.com

摘要：马赫的贡献在于揭示了引力速度和光速的内禀性质。但他把整体与部分的相对绝对化；他不像威滕的弦/M（膜）理论，威滕不用一个单独的整体，而是一个整理的网络观测，并且是一个数学模型描述，所有的部分在整体下都是等效的，并且具有意想不到多的对应关系，可以解释从无限小的粒子到无限大的宇宙的统一场。但M理论网络还不能解释生物场、认识场、经济场，现在统一超弦和三旋的膜理论的类圈体及转座子学说，却是一个超M理论，可以解释从无限小的粒子到无限大的宇宙的统一场、生物场、认识场、经济场。

[叶眺新. 统一超弦和三旋的膜理论. AcademArena. 2021;13(4):65-70]. ISSN 1553-992X (print); ISSN2158-771X

(online). http://www.sciencepub.net/academia.6.doi:10.7537/marsaaj130421.06.

关键词：马赫原理、相对论、膜、三旋理论

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Practice and Understanding of the Goldbach Problem (A)

Tong Xinping (童 信 平)

xpt2008@126.com

Abstract  Practice shows: Without enough parameters, 1+2 cannot estimate 1+1 and 1+1×1. At the same time, it is pointed out that among the prime numbers not greater than N, the prime number 6t-1 is more than the prime number 6t+1, (this is the "detail" that Hardy and the others did not notice.) "detail" (= "remainder") affects  Represents the negligible oscillation in the accuracy curve of the number r2(N) of Hardy-Litttlewood conjecture (A) in 1921. (In 1989, Hua Luogeng (华罗庚) confirmed that conjecture (A) is the "main term" of even Goldbach's problem.)

[Tong Xinping(童信平)Practice and Understanding of theGoldbachProblem(A)AcademArena2021;13(4):71-75].ISSN1553-992X(print);ISSN2158-771X(online).http://www.sciencepub.net/academia. 7. doi:10.7537/marsaaj130421.07.

Keywords: Practice; Understanding; Goldbach; Problem

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Application Of Classical Algebra To Friedman Equations

S. Kalimuthu

2/394, Kanjampatti B.O, Pollachi Via, Tamil Nadu – 642 003, India

Email: owlskalimuthu@gmail.com Mobile: + 91 8220541577

Researcher ID: AAP-4476-2020, Scopus Author ID: 25723330600

ORCID ID:  0000-0001-7978-9013 , MR ID 1048338 , INSPIRE ID-00801168

Abstract：The density of the universe determines the geometry and fate of the universe. According to Freedman’s equations of general relativity published in 1922 and 1924, the geometry of the universe may be closed, open and flat. It all depends upon the curvature of the universe also. Various results of Cosmic Microwave Background Radiation (CMBR), NASA’s Wilkinson Microwave Anisotropy Probe (WMAP), and ESA’s Planck spacecraft probes found that our universe is flat within a margin of 0.4% error. In this short work, by applying the laws of quadratic equations, we attempt to show that OUR UNIVERSE IS FLAT.

[S. Kalimuthu Application Of Classical Algebra To Friedman EquationsAcademArena2021;13(4):76-77].ISSN1553-992X(print);ISSN2158-771X(online).http://www.sciencepub.net/academia.8. doi:10.7537/marsaaj130421.08.

Keywords: Cosmic background Radiation, Freedman Equation, Geometry of the Universe

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全息生物学如何复兴(摘要）

---我国全息学与西方全息学比较

叶眺新（绵阳日报社）

Recommended: 王德奎 (Wang Dekui), 绵阳日报社, 绵阳, 四川 621000, 中国, y-tx@163.com

摘要：21世纪，当我国曾极为热门的生物全息研究走入低潮时，我们看到西方的全息学变得越来越重要和越来越可信，我们感到了一种未完成的责任。中国和西方的全息学都来源于全息术的启发。

[叶眺新 全息生物学如何复兴(摘要）---我国全息学与西方全息学比较 Academ Arena 2021;13(4):78-80]. ISSN 1553-992X(print);ISSN2158-771X(online).http://www.sciencepub.net/academia. 9. doi:10.7537/marsaaj130421.09.

关键词：21世纪;生物全息; 西方; 责任; 中国; 全息术

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